Eosinophilic oesophagitis: Relationship of quality of life with clinical, endoscopic and histological activity

E. Safroneeva, M. Coslovsky, C. E. Kuehni, M. Zwahlen, N. A. Haas, R. Panczak, T. H. Taft, I. Hirano, E. S. Dellon, N. Gonsalves, J. Leung, C. Bussmann, J. T. Woosley, P. Yan, Y. Romero, G. T. Furuta, Sandeep Gupta, S. S. Aceves, M. Chehade, A. StraumannA. M. Schoepfer

Research output: Contribution to journalArticle

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Abstract

Background Knowledge about determinants of quality of life (QoL) in eosinophilic oesophagitis (EoO) patients helps to identify patients at risk of experiencing poor QoL and to tailor therapeutic interventions accordingly. Aim To evaluate the impact of symptom severity, endoscopic and histological activity on EoE-specific QoL in adult EoE patients. Methods Ninety-eight adult EoE patients were prospectively included (64% male, median age 39 years). Patients completed two validated instruments to assess EoE-specific QoL (EoO-QoL-A) and symptom severity (adult EoE activity index patient-reported outcome) and then underwent esophagogastroduodenoscopy with biopsy sampling. Physicians reported standardised information on EoE-associated endoscopic and histological alterations. The Spearman's rank correlation coefficient was calculated to determine the relationship between QoL and symptom severity. Linear regression and analysis of variance was used to quantify the extent to which variations in severity of EoE symptoms, endoscopic and histological findings explain variations in QoL. Results Quality of life strongly correlated with symptom severity (r = 0.610, P <0.001). While the variation in severity of symptoms, endoscopic and histological findings alone explained 38%, 35% and 22% of the variability in EoE-related QoL, respectively, these together explained 60% of variation. Symptom severity explained 18-35% of the variation in each of the five QoL subscale scores. Conclusions Eosinophilic oesophagitis symptom severity and biological disease activity determine QoL in adult patients with eosinophilic oesophagitis. Therefore, reduction in both eosinophilic oesophagitis symptoms as well as biological disease activity is essential for improvement of QoL in adult patients. Clinicaltrials.gov number, NCT00939263.

Original languageEnglish (US)
Pages (from-to)1000-1010
Number of pages11
JournalAlimentary Pharmacology and Therapeutics
Volume42
Issue number8
DOIs
StatePublished - Oct 1 2015

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Eosinophilic Esophagitis
Quality of Life
Digestive System Endoscopy
Nonparametric Statistics

ASJC Scopus subject areas

  • Pharmacology (medical)

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Safroneeva, E., Coslovsky, M., Kuehni, C. E., Zwahlen, M., Haas, N. A., Panczak, R., ... Schoepfer, A. M. (2015). Eosinophilic oesophagitis: Relationship of quality of life with clinical, endoscopic and histological activity. Alimentary Pharmacology and Therapeutics, 42(8), 1000-1010. https://doi.org/10.1111/apt.13370

Eosinophilic oesophagitis : Relationship of quality of life with clinical, endoscopic and histological activity. / Safroneeva, E.; Coslovsky, M.; Kuehni, C. E.; Zwahlen, M.; Haas, N. A.; Panczak, R.; Taft, T. H.; Hirano, I.; Dellon, E. S.; Gonsalves, N.; Leung, J.; Bussmann, C.; Woosley, J. T.; Yan, P.; Romero, Y.; Furuta, G. T.; Gupta, Sandeep; Aceves, S. S.; Chehade, M.; Straumann, A.; Schoepfer, A. M.

In: Alimentary Pharmacology and Therapeutics, Vol. 42, No. 8, 01.10.2015, p. 1000-1010.

Research output: Contribution to journalArticle

Safroneeva, E, Coslovsky, M, Kuehni, CE, Zwahlen, M, Haas, NA, Panczak, R, Taft, TH, Hirano, I, Dellon, ES, Gonsalves, N, Leung, J, Bussmann, C, Woosley, JT, Yan, P, Romero, Y, Furuta, GT, Gupta, S, Aceves, SS, Chehade, M, Straumann, A & Schoepfer, AM 2015, 'Eosinophilic oesophagitis: Relationship of quality of life with clinical, endoscopic and histological activity', Alimentary Pharmacology and Therapeutics, vol. 42, no. 8, pp. 1000-1010. https://doi.org/10.1111/apt.13370
Safroneeva, E. ; Coslovsky, M. ; Kuehni, C. E. ; Zwahlen, M. ; Haas, N. A. ; Panczak, R. ; Taft, T. H. ; Hirano, I. ; Dellon, E. S. ; Gonsalves, N. ; Leung, J. ; Bussmann, C. ; Woosley, J. T. ; Yan, P. ; Romero, Y. ; Furuta, G. T. ; Gupta, Sandeep ; Aceves, S. S. ; Chehade, M. ; Straumann, A. ; Schoepfer, A. M. / Eosinophilic oesophagitis : Relationship of quality of life with clinical, endoscopic and histological activity. In: Alimentary Pharmacology and Therapeutics. 2015 ; Vol. 42, No. 8. pp. 1000-1010.
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abstract = "Background Knowledge about determinants of quality of life (QoL) in eosinophilic oesophagitis (EoO) patients helps to identify patients at risk of experiencing poor QoL and to tailor therapeutic interventions accordingly. Aim To evaluate the impact of symptom severity, endoscopic and histological activity on EoE-specific QoL in adult EoE patients. Methods Ninety-eight adult EoE patients were prospectively included (64{\%} male, median age 39 years). Patients completed two validated instruments to assess EoE-specific QoL (EoO-QoL-A) and symptom severity (adult EoE activity index patient-reported outcome) and then underwent esophagogastroduodenoscopy with biopsy sampling. Physicians reported standardised information on EoE-associated endoscopic and histological alterations. The Spearman's rank correlation coefficient was calculated to determine the relationship between QoL and symptom severity. Linear regression and analysis of variance was used to quantify the extent to which variations in severity of EoE symptoms, endoscopic and histological findings explain variations in QoL. Results Quality of life strongly correlated with symptom severity (r = 0.610, P <0.001). While the variation in severity of symptoms, endoscopic and histological findings alone explained 38{\%}, 35{\%} and 22{\%} of the variability in EoE-related QoL, respectively, these together explained 60{\%} of variation. Symptom severity explained 18-35{\%} of the variation in each of the five QoL subscale scores. Conclusions Eosinophilic oesophagitis symptom severity and biological disease activity determine QoL in adult patients with eosinophilic oesophagitis. Therefore, reduction in both eosinophilic oesophagitis symptoms as well as biological disease activity is essential for improvement of QoL in adult patients. Clinicaltrials.gov number, NCT00939263.",
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T2 - Relationship of quality of life with clinical, endoscopic and histological activity

AU - Safroneeva, E.

AU - Coslovsky, M.

AU - Kuehni, C. E.

AU - Zwahlen, M.

AU - Haas, N. A.

AU - Panczak, R.

AU - Taft, T. H.

AU - Hirano, I.

AU - Dellon, E. S.

AU - Gonsalves, N.

AU - Leung, J.

AU - Bussmann, C.

AU - Woosley, J. T.

AU - Yan, P.

AU - Romero, Y.

AU - Furuta, G. T.

AU - Gupta, Sandeep

AU - Aceves, S. S.

AU - Chehade, M.

AU - Straumann, A.

AU - Schoepfer, A. M.

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N2 - Background Knowledge about determinants of quality of life (QoL) in eosinophilic oesophagitis (EoO) patients helps to identify patients at risk of experiencing poor QoL and to tailor therapeutic interventions accordingly. Aim To evaluate the impact of symptom severity, endoscopic and histological activity on EoE-specific QoL in adult EoE patients. Methods Ninety-eight adult EoE patients were prospectively included (64% male, median age 39 years). Patients completed two validated instruments to assess EoE-specific QoL (EoO-QoL-A) and symptom severity (adult EoE activity index patient-reported outcome) and then underwent esophagogastroduodenoscopy with biopsy sampling. Physicians reported standardised information on EoE-associated endoscopic and histological alterations. The Spearman's rank correlation coefficient was calculated to determine the relationship between QoL and symptom severity. Linear regression and analysis of variance was used to quantify the extent to which variations in severity of EoE symptoms, endoscopic and histological findings explain variations in QoL. Results Quality of life strongly correlated with symptom severity (r = 0.610, P <0.001). While the variation in severity of symptoms, endoscopic and histological findings alone explained 38%, 35% and 22% of the variability in EoE-related QoL, respectively, these together explained 60% of variation. Symptom severity explained 18-35% of the variation in each of the five QoL subscale scores. Conclusions Eosinophilic oesophagitis symptom severity and biological disease activity determine QoL in adult patients with eosinophilic oesophagitis. Therefore, reduction in both eosinophilic oesophagitis symptoms as well as biological disease activity is essential for improvement of QoL in adult patients. Clinicaltrials.gov number, NCT00939263.

AB - Background Knowledge about determinants of quality of life (QoL) in eosinophilic oesophagitis (EoO) patients helps to identify patients at risk of experiencing poor QoL and to tailor therapeutic interventions accordingly. Aim To evaluate the impact of symptom severity, endoscopic and histological activity on EoE-specific QoL in adult EoE patients. Methods Ninety-eight adult EoE patients were prospectively included (64% male, median age 39 years). Patients completed two validated instruments to assess EoE-specific QoL (EoO-QoL-A) and symptom severity (adult EoE activity index patient-reported outcome) and then underwent esophagogastroduodenoscopy with biopsy sampling. Physicians reported standardised information on EoE-associated endoscopic and histological alterations. The Spearman's rank correlation coefficient was calculated to determine the relationship between QoL and symptom severity. Linear regression and analysis of variance was used to quantify the extent to which variations in severity of EoE symptoms, endoscopic and histological findings explain variations in QoL. Results Quality of life strongly correlated with symptom severity (r = 0.610, P <0.001). While the variation in severity of symptoms, endoscopic and histological findings alone explained 38%, 35% and 22% of the variability in EoE-related QoL, respectively, these together explained 60% of variation. Symptom severity explained 18-35% of the variation in each of the five QoL subscale scores. Conclusions Eosinophilic oesophagitis symptom severity and biological disease activity determine QoL in adult patients with eosinophilic oesophagitis. Therefore, reduction in both eosinophilic oesophagitis symptoms as well as biological disease activity is essential for improvement of QoL in adult patients. Clinicaltrials.gov number, NCT00939263.

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