Epicardial maps of atrial fibrillation after linear ablation lesions

Haris J. Sih, Edward J. Berbari, Douglas P. Zipes

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Introduction: The purpose of this study was to investigate the mechanisms by which atrial linear ablation lesions eliminate atrial fibrillation (AF). Methods and Results: With an array of 112 unipole, epicardial maps of electrically induced AF in 6 dogs (acute group), self- sustained AF in 6 dogs (chronic group), and sinus rhythm and atrial pacing in 3 dogs (control group) were analyzed before and after creating linear radiofrequency ablation lesions in both atria that eliminated the AF. In the acute and chronic groups, activation maps showed multiple wavelets with complex patterns of activation and reentry during AF. Conduction velocity and the number, size, and complexity of wavelets did not change; whereas median fibrillatory cycle length increased with the number of linear lesions. In the control group, refractoriness and conduction velocity were unaffected by the number of lesions. Conclusions: In these models of AF, linear lesions that eliminate AF increase the cycle length of AF without changing conduction velocity, number or size of wavelets, or complexity of activation patterns.

Original languageEnglish (US)
Pages (from-to)1046-1054
Number of pages9
JournalJournal of cardiovascular electrophysiology
Volume8
Issue number9
DOIs
StatePublished - 1997

Keywords

  • Atrial fibrillation
  • Cardiac mapping
  • Methacholine
  • Radiofrequency catheter ablation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology

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