Epidemiology and risk factors for human papillomavirus infection in a diverse sample of low-income young women

Tasneem Shikary, David I. Bernstein, Yan Jin, Gregory Zimet, Susan L. Rosenthal, Jessica A. Kahn

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background: Two HPV vaccines prevent infection with HPV-16 and HPV-18, high-risk (cancer-associated) HPV types which together cause approximately 70% of cervical cancers; one vaccine also prevents HPV-6 and HPV-11, which together cause approximately 90% of anogenital warts. Defining type-specific HPV epidemiology in sexually experienced women will help estimate the potential clinical benefits of vaccinating this population. Objectives: To examine HPV epidemiology in a diverse sample of sexually experienced women, and to determine factors associated with high-risk HPV and vaccine-type HPV (HPV-6, HPV-11, HPV-16 and HPV-18). Study design: Cross-sectional study of 13-26-year-old women (N = 409) who completed a questionnaire and provided a cervicovaginal swab. Swabs were genotyped for HPV using PCR amplification. Logistic regression models were used to determine whether participant characteristics, knowledge, and behaviors were associated with high-risk and vaccine-type HPV. Results: Most women (68.4%) were positive for ≥1 HPV type, 59.5% were positive for ≥1 high-risk type, 33.1% were positive for ≥1 vaccine-type HPV, and 3.5% were positive for both HPV-16 and HPV-18: none was positive for all four vaccine types. In adjusted logistic regression models, Black race (OR 2.03, 95% CI 1.21-3.41) and lifetime number of male sexual partners (OR 4.79, 95% CI 2.04-11.23 for ≥10 partner vs. ≤1 partner) were independently associated with high-risk HPV infection. Conclusions: HPV prevalence was very high in this sample of sexually active young women, but <5% were positive for both HPV-16 and HPV-18, suggesting that vaccination could be beneficial for many individual women who are sexually experienced.

Original languageEnglish
Pages (from-to)107-111
Number of pages5
JournalJournal of Clinical Virology
Volume46
Issue number2
DOIs
StatePublished - Oct 2009

Fingerprint

Papillomavirus Infections
Human papillomavirus 18
Human papillomavirus 16
Papillomavirus Vaccines
Epidemiology
Human papillomavirus 11
Logistic Models
Vaccines
Warts
Sexual Partners
Infection
Uterine Cervical Neoplasms
Vaccination
Cross-Sectional Studies
Polymerase Chain Reaction
Population
Neoplasms

Keywords

  • Cervical cancer
  • Epidemiology
  • Human papillomavirus
  • Sexually transmitted infection
  • Vaccination

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Epidemiology and risk factors for human papillomavirus infection in a diverse sample of low-income young women. / Shikary, Tasneem; Bernstein, David I.; Jin, Yan; Zimet, Gregory; Rosenthal, Susan L.; Kahn, Jessica A.

In: Journal of Clinical Virology, Vol. 46, No. 2, 10.2009, p. 107-111.

Research output: Contribution to journalArticle

Shikary, Tasneem ; Bernstein, David I. ; Jin, Yan ; Zimet, Gregory ; Rosenthal, Susan L. ; Kahn, Jessica A. / Epidemiology and risk factors for human papillomavirus infection in a diverse sample of low-income young women. In: Journal of Clinical Virology. 2009 ; Vol. 46, No. 2. pp. 107-111.
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abstract = "Background: Two HPV vaccines prevent infection with HPV-16 and HPV-18, high-risk (cancer-associated) HPV types which together cause approximately 70{\%} of cervical cancers; one vaccine also prevents HPV-6 and HPV-11, which together cause approximately 90{\%} of anogenital warts. Defining type-specific HPV epidemiology in sexually experienced women will help estimate the potential clinical benefits of vaccinating this population. Objectives: To examine HPV epidemiology in a diverse sample of sexually experienced women, and to determine factors associated with high-risk HPV and vaccine-type HPV (HPV-6, HPV-11, HPV-16 and HPV-18). Study design: Cross-sectional study of 13-26-year-old women (N = 409) who completed a questionnaire and provided a cervicovaginal swab. Swabs were genotyped for HPV using PCR amplification. Logistic regression models were used to determine whether participant characteristics, knowledge, and behaviors were associated with high-risk and vaccine-type HPV. Results: Most women (68.4{\%}) were positive for ≥1 HPV type, 59.5{\%} were positive for ≥1 high-risk type, 33.1{\%} were positive for ≥1 vaccine-type HPV, and 3.5{\%} were positive for both HPV-16 and HPV-18: none was positive for all four vaccine types. In adjusted logistic regression models, Black race (OR 2.03, 95{\%} CI 1.21-3.41) and lifetime number of male sexual partners (OR 4.79, 95{\%} CI 2.04-11.23 for ≥10 partner vs. ≤1 partner) were independently associated with high-risk HPV infection. Conclusions: HPV prevalence was very high in this sample of sexually active young women, but <5{\%} were positive for both HPV-16 and HPV-18, suggesting that vaccination could be beneficial for many individual women who are sexually experienced.",
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T1 - Epidemiology and risk factors for human papillomavirus infection in a diverse sample of low-income young women

AU - Shikary, Tasneem

AU - Bernstein, David I.

AU - Jin, Yan

AU - Zimet, Gregory

AU - Rosenthal, Susan L.

AU - Kahn, Jessica A.

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AB - Background: Two HPV vaccines prevent infection with HPV-16 and HPV-18, high-risk (cancer-associated) HPV types which together cause approximately 70% of cervical cancers; one vaccine also prevents HPV-6 and HPV-11, which together cause approximately 90% of anogenital warts. Defining type-specific HPV epidemiology in sexually experienced women will help estimate the potential clinical benefits of vaccinating this population. Objectives: To examine HPV epidemiology in a diverse sample of sexually experienced women, and to determine factors associated with high-risk HPV and vaccine-type HPV (HPV-6, HPV-11, HPV-16 and HPV-18). Study design: Cross-sectional study of 13-26-year-old women (N = 409) who completed a questionnaire and provided a cervicovaginal swab. Swabs were genotyped for HPV using PCR amplification. Logistic regression models were used to determine whether participant characteristics, knowledge, and behaviors were associated with high-risk and vaccine-type HPV. Results: Most women (68.4%) were positive for ≥1 HPV type, 59.5% were positive for ≥1 high-risk type, 33.1% were positive for ≥1 vaccine-type HPV, and 3.5% were positive for both HPV-16 and HPV-18: none was positive for all four vaccine types. In adjusted logistic regression models, Black race (OR 2.03, 95% CI 1.21-3.41) and lifetime number of male sexual partners (OR 4.79, 95% CI 2.04-11.23 for ≥10 partner vs. ≤1 partner) were independently associated with high-risk HPV infection. Conclusions: HPV prevalence was very high in this sample of sexually active young women, but <5% were positive for both HPV-16 and HPV-18, suggesting that vaccination could be beneficial for many individual women who are sexually experienced.

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KW - Epidemiology

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KW - Sexually transmitted infection

KW - Vaccination

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