Epigenetic and lncRNA regulation of cardiac pathophysiology

Ching-Pin Chang, Pei Han

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Our developmental studies provide an insight into the pathogenesis of heart failure in adults. These studies reveal a mechanistic link between fetal cardiomyocytes and pathologically stressed adult cardiomyocytes at the level of chromatin regulation. In embryos, chromatin-regulating factors within the cardiomyocytes respond to developmental signals to program cardiac gene expression to promote cell proliferation and inhibit premature cell differentiation. In the neonatal period, the activity of these developmental chromatin regulators is quickly turned off in cardiomyocytes, coinciding with the cessation of cell proliferation and advance in cell differentiation toward adult maturity. When the mature hearts are pathologically stressed, those chromatin regulators essential for cardiomyocyte development in embryos are reactivated, triggering gene reprogramming to a fetal-like state and pathological cardiac hypertrophy. Furthermore, in the study of chromatin regulation and cardiac gene expression, we identified a long noncoding RNA that interacts with chromatin remodeling factor to regulate the cardiac response to environmental changes.This article is part of a Special Issue entitled: Cardiomyocyte Biology: Integration of Developmental and Environmental Cues in the Heart edited by Marcus Schaub and Hughes Abriel.

Original languageEnglish (US)
JournalBiochimica et Biophysica Acta - Molecular Cell Research
DOIs
StateAccepted/In press - Dec 17 2015

Fingerprint

Long Noncoding RNA
Cardiac Myocytes
Epigenomics
Chromatin
Cell Differentiation
Cell Proliferation
Developmental Biology
Chromatin Assembly and Disassembly
Cardiomegaly
Gene Expression Regulation
Embryonic Development
Cues
Embryonic Structures
Heart Failure
Gene Expression
Genes

Keywords

  • BAF
  • Brg1
  • Chromatin
  • Development
  • Gene expression
  • Heart failure
  • Hypertrophy
  • Mhrt
  • Myheart

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Epigenetic and lncRNA regulation of cardiac pathophysiology. / Chang, Ching-Pin; Han, Pei.

In: Biochimica et Biophysica Acta - Molecular Cell Research, 17.12.2015.

Research output: Contribution to journalArticle

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