Epigenetic "bivalently marked" process of cancer stem cell-driven tumorigenesis

Curt Balch, Kenneth Nephew, Tim H M Huang, Sharmila A. Bapat

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Silencing of tumor suppressor genes (TSGs), by DNA methylation, is well known in adult cancers. However, based on the "stem cell" theory of tumorigenesis, the early epigenetic events arising in malignant precursors remain unknown. A recent report(1) demonstrates that, while pluripotent embryonic stem cells lack DNA methylation and possess a "bivalent" pattern of activating and repressive histone marks in numerous TSGs, analogous multipotent malignant cells derived from germ cell tumors (embryonic carcinoma cells) gain additional silencing modifications to those same genes. These results suggest a possible mechanism by which aberrant differentiation, mediated by histone and DNA methylation, instigates tumor progression.

Original languageEnglish
Pages (from-to)842-845
Number of pages4
JournalBioEssays
Volume29
Issue number9
DOIs
StatePublished - Sep 2007

Fingerprint

Neoplastic Stem Cells
DNA methylation
DNA Methylation
Stem cells
Epigenomics
epigenetics
carcinogenesis
stem cells
Tumors
Carcinogenesis
tumor suppressor genes
Tumor Suppressor Genes
histones
neoplasms
Genes
Histone Code
Histones
Pluripotent Stem Cells
Germ Cell and Embryonal Neoplasms
Cells

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Biochemistry
  • Cell Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Agricultural and Biological Sciences (miscellaneous)
  • Plant Science

Cite this

Epigenetic "bivalently marked" process of cancer stem cell-driven tumorigenesis. / Balch, Curt; Nephew, Kenneth; Huang, Tim H M; Bapat, Sharmila A.

In: BioEssays, Vol. 29, No. 9, 09.2007, p. 842-845.

Research output: Contribution to journalArticle

Balch, Curt ; Nephew, Kenneth ; Huang, Tim H M ; Bapat, Sharmila A. / Epigenetic "bivalently marked" process of cancer stem cell-driven tumorigenesis. In: BioEssays. 2007 ; Vol. 29, No. 9. pp. 842-845.
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