Epigenetic dysregulation in cancer

Andrew G. Muntean, Jay L. Hess

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

One of the great paradoxes in cellular differentiation is how cells with identical DNA sequences differentiate into so many different cell types. The mechanisms underlying this process involve epigenetic regulation mediated by alterations in DNA methylation, histone posttranslational modifications, and nucleosome remodeling. It is becoming increasingly clear that disruption of the "epigenome" as a result of alterations in epigenetic regulators is a fundamental mechanism in cancer. This has major implications for the future of both molecular diagnostics as well as cancer chemotherapy.

Original languageEnglish (US)
Pages (from-to)1353-1361
Number of pages9
JournalAmerican Journal of Pathology
Volume175
Issue number4
DOIs
StatePublished - 2009
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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