Epigenetic medicine and fetal alcohol spectrum disorders

Marisol Resendiz, Yuanyuan Chen, Nail C. Öztürk, Feng C. Zhou

Research output: Contribution to journalReview article

33 Scopus citations

Abstract

Epigenetic medicine is still in its infancy. To date, only a handful of diseases have documented epigenetic correlates upstream of gene regulation including cancer, developmental syndromes and late-onset diseases. The finding that epigenetic markers are dynamic and heterogeneous at tissue and cellular levels, combined with recent identification of a new form of functionally distinct DNA methylation has opened a wider window for investigators to pry into the epigenetic world. It is anticipated that many diseases will be elucidated through this epigenetic inquiry. In this review, we discuss the normal course of DNA methylation during development, taking alcohol as a demonstrator of the epigenetic impact of environmental factors in disease etiology, particularly the growth retardation and neurodevelopmental deficits of fetal alcohol spectrum disorders.

Original languageEnglish (US)
Pages (from-to)73-86
Number of pages14
JournalEpigenomics
Volume5
Issue number1
DOIs
StatePublished - Feb 1 2013

Keywords

  • 5-hydroxymethylcytosine
  • developmental syndromes
  • DNA methylation
  • fetal alcohol syndrome
  • late-onset disease
  • transgenerational epigenetics

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

Fingerprint Dive into the research topics of 'Epigenetic medicine and fetal alcohol spectrum disorders'. Together they form a unique fingerprint.

  • Cite this