Epigenetic regulation of tumor suppressors in t(8

21)-containing AML

Genyan Yang, Waleed Khalaf, Louis van de Locht, Joop H. Jansen, Bert A. van der Reijden, Carsten Müller-Tidow, H. Ruud Delwel, Hubert Serve, D. Clapp, Scott W. Hiebert

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The t(8;21) is perhaps the most frequent chromosomal translocation associated with acute myeloid leukemia. The translocation creates a fusion protein that consists of the DNA binding domain of the RUNX1 transcription factor fused to the MTG8 transcriptional co-repressor to create a potent transcriptional repressor. Here, we discuss the possibility that the t(8;21) fusion protein represses tumor suppressors that regulate the RAS signaling pathway and the p53 oncogenic checkpoint.

Original languageEnglish
Pages (from-to)329-330
Number of pages2
JournalAnnals of Hematology
Volume83
Issue number6
DOIs
StatePublished - Jun 2004

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Tumor Suppressor Proteins
Co-Repressor Proteins
Genetic Translocation
DNA-Binding Proteins
Acute Myeloid Leukemia
Epigenomics
Transcription Factors
Neoplasms

Keywords

  • 14ARF
  • ETO
  • MTG8
  • NF1
  • Ras
  • RUNX1

ASJC Scopus subject areas

  • Hematology

Cite this

Yang, G., Khalaf, W., van de Locht, L., Jansen, J. H., van der Reijden, B. A., Müller-Tidow, C., ... Hiebert, S. W. (2004). Epigenetic regulation of tumor suppressors in t(8: 21)-containing AML. Annals of Hematology, 83(6), 329-330. https://doi.org/10.1007/s00277-003-0841-8

Epigenetic regulation of tumor suppressors in t(8 : 21)-containing AML. / Yang, Genyan; Khalaf, Waleed; van de Locht, Louis; Jansen, Joop H.; van der Reijden, Bert A.; Müller-Tidow, Carsten; Delwel, H. Ruud; Serve, Hubert; Clapp, D.; Hiebert, Scott W.

In: Annals of Hematology, Vol. 83, No. 6, 06.2004, p. 329-330.

Research output: Contribution to journalArticle

Yang, G, Khalaf, W, van de Locht, L, Jansen, JH, van der Reijden, BA, Müller-Tidow, C, Delwel, HR, Serve, H, Clapp, D & Hiebert, SW 2004, 'Epigenetic regulation of tumor suppressors in t(8: 21)-containing AML', Annals of Hematology, vol. 83, no. 6, pp. 329-330. https://doi.org/10.1007/s00277-003-0841-8
Yang G, Khalaf W, van de Locht L, Jansen JH, van der Reijden BA, Müller-Tidow C et al. Epigenetic regulation of tumor suppressors in t(8: 21)-containing AML. Annals of Hematology. 2004 Jun;83(6):329-330. https://doi.org/10.1007/s00277-003-0841-8
Yang, Genyan ; Khalaf, Waleed ; van de Locht, Louis ; Jansen, Joop H. ; van der Reijden, Bert A. ; Müller-Tidow, Carsten ; Delwel, H. Ruud ; Serve, Hubert ; Clapp, D. ; Hiebert, Scott W. / Epigenetic regulation of tumor suppressors in t(8 : 21)-containing AML. In: Annals of Hematology. 2004 ; Vol. 83, No. 6. pp. 329-330.
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