Epigenetic regulation of tumor suppressors in t(8:21)-containing AML

Genyan Yang, Waleed Khalaf, Louis van de Locht, Joop H. Jansen, Bert A. van der Reijden, Carsten Müller-Tidow, H. Ruud Delwel, Hubert Serve, D. Wade Clapp, Scott W. Hiebert

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

The t(8;21) is perhaps the most frequent chromosomal translocation associated with acute myeloid leukemia. The translocation creates a fusion protein that consists of the DNA binding domain of the RUNX1 transcription factor fused to the MTG8 transcriptional co-repressor to create a potent transcriptional repressor. Here, we discuss the possibility that the t(8;21) fusion protein represses tumor suppressors that regulate the RAS signaling pathway and the p53 oncogenic checkpoint.

Original languageEnglish (US)
Pages (from-to)329-330
Number of pages2
JournalAnnals of Hematology
Volume83
Issue number6
DOIs
StatePublished - Jun 2004

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Keywords

  • 14ARF
  • ETO
  • MTG8
  • NF1
  • Ras
  • RUNX1

ASJC Scopus subject areas

  • Hematology

Cite this

Yang, G., Khalaf, W., van de Locht, L., Jansen, J. H., van der Reijden, B. A., Müller-Tidow, C., Delwel, H. R., Serve, H., Clapp, D. W., & Hiebert, S. W. (2004). Epigenetic regulation of tumor suppressors in t(8:21)-containing AML. Annals of Hematology, 83(6), 329-330. https://doi.org/10.1007/s00277-003-0841-8