Epigenetic targeting and histone deacetylase inhibition in RCC

Swathi Ramakrishnan, Roberto Pili

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Epigenetic regulation through histone modifications and DNA methylation of critical genes involved in cell cycle regulation, invasion, metastasis, and tumor-induced angiogenesis has been shown to play an important role in cancer development. Epigenetic changes are potentially reversible and therefore represent a target for therapeutic intervention with the potential of modulating oncogenes/tumor suppressor genes involved in the initiation and progression of cancer. Rational combination strategies that take advantage of transcriptional and posttranslational modifications induced by histone deacetylase inhibitors have generated promising preclinical results and are actively being tested in clinical trials. Preclinical and clinical evidence suggests that kidney tumors are ideal candidates for epigenetic therapies in view of specific mutations in histone modifier genes, overexpression of angiogenesis factors, and intrinsic sensitivity to immunotherapies. This chapter focuses on epigenetic changes in renal cell carcinoma (RCC) and, in particular, on histone modifications and therapeutic approaches currently underway targeting these epigenetic changes.

Original languageEnglish (US)
Title of host publicationRenal Cell Carcinoma: Translational Biology, Personalized Medicine, and Novel Therapeutic Targets
PublisherSpringer US
Pages193-211
Number of pages19
Volume9781461424000
ISBN (Electronic)9781461424000
ISBN (Print)1461423996, 9781461423997
DOIs
StatePublished - Nov 1 2012
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Epigenetic targeting and histone deacetylase inhibition in RCC'. Together they form a unique fingerprint.

  • Cite this

    Ramakrishnan, S., & Pili, R. (2012). Epigenetic targeting and histone deacetylase inhibition in RCC. In Renal Cell Carcinoma: Translational Biology, Personalized Medicine, and Novel Therapeutic Targets (Vol. 9781461424000, pp. 193-211). Springer US. https://doi.org/10.1007/978-1-4614-2400-0_9