Epigenetics and cardiovascular development

Ching-Pin Chang, Benoit G. Bruneau

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

The cardiovascular system is broadly composed of the heart, which pumps blood, and the blood vessels, which carry blood to and from tissues of the body. Heart malformations are the most serious common birth defect, affecting at least 2% of newborns and leading to significant morbidity and mortality. Severe heart malformations cause heart failure in fetuses, infants, and children, whereas milder heart defects may not trigger significant heart dysfunction until early or midadulthood. Severe vasculogenesis or angiogenesis defects in embryos are incompatible with life, and anomalous arterial patterning may cause vascular aberrancies that often require surgical treatment. It is therefore important to understand the underlying mechanisms that control cardiovascular development. Understanding developmental mechanisms will also help us design better strategies to regenerate cardiovascular tissues for therapeutic purposes. An important mechanism regulating genes involves the modification of chromatin, the higher-order structure in which DNA is packaged. Recent studies have greatly expanded our understanding of the regulation of cardiovascular development at the chromatin level, including the remodeling of chromatin and the modification of histones. Chromatin-level regulation integrates multiple inputs and coordinates broad gene expression programs. Thus, understanding chromatin-level regulation will allow for a better appreciation of gene regulation as a whole and may set a fundamental basis for cardiovascular disease. This review focuses on how chromatin-remodeling and histone-modifying factors regulate gene expression to control cardiovascular development.

Original languageEnglish (US)
Pages (from-to)41-68
Number of pages28
JournalAnnual Review of Physiology
Volume74
DOIs
StatePublished - 2012
Externally publishedYes

Fingerprint

Epigenomics
Chromatin
Chromatin Assembly and Disassembly
Congenital Heart Defects
Blood Vessels
Histone Code
Gene Expression
Cardiovascular System
Histones
Genes
Fetus
Cardiovascular Diseases
Embryonic Structures
Heart Failure
Newborn Infant
Morbidity
Mortality
DNA
Therapeutics

Keywords

  • Chromatin remodeling
  • Congenital heart disease
  • Gene expression
  • Histone modification
  • Vascular disease

ASJC Scopus subject areas

  • Physiology

Cite this

Epigenetics and cardiovascular development. / Chang, Ching-Pin; Bruneau, Benoit G.

In: Annual Review of Physiology, Vol. 74, 2012, p. 41-68.

Research output: Contribution to journalArticle

Chang, Ching-Pin ; Bruneau, Benoit G. / Epigenetics and cardiovascular development. In: Annual Review of Physiology. 2012 ; Vol. 74. pp. 41-68.
@article{8e002c2167604fe69f756b89bb92e82f,
title = "Epigenetics and cardiovascular development",
abstract = "The cardiovascular system is broadly composed of the heart, which pumps blood, and the blood vessels, which carry blood to and from tissues of the body. Heart malformations are the most serious common birth defect, affecting at least 2{\%} of newborns and leading to significant morbidity and mortality. Severe heart malformations cause heart failure in fetuses, infants, and children, whereas milder heart defects may not trigger significant heart dysfunction until early or midadulthood. Severe vasculogenesis or angiogenesis defects in embryos are incompatible with life, and anomalous arterial patterning may cause vascular aberrancies that often require surgical treatment. It is therefore important to understand the underlying mechanisms that control cardiovascular development. Understanding developmental mechanisms will also help us design better strategies to regenerate cardiovascular tissues for therapeutic purposes. An important mechanism regulating genes involves the modification of chromatin, the higher-order structure in which DNA is packaged. Recent studies have greatly expanded our understanding of the regulation of cardiovascular development at the chromatin level, including the remodeling of chromatin and the modification of histones. Chromatin-level regulation integrates multiple inputs and coordinates broad gene expression programs. Thus, understanding chromatin-level regulation will allow for a better appreciation of gene regulation as a whole and may set a fundamental basis for cardiovascular disease. This review focuses on how chromatin-remodeling and histone-modifying factors regulate gene expression to control cardiovascular development.",
keywords = "Chromatin remodeling, Congenital heart disease, Gene expression, Histone modification, Vascular disease",
author = "Ching-Pin Chang and Bruneau, {Benoit G.}",
year = "2012",
doi = "10.1146/annurev-physiol-020911-153242",
language = "English (US)",
volume = "74",
pages = "41--68",
journal = "Annual Review of Physiology",
issn = "0066-4278",
publisher = "Annual Reviews Inc.",

}

TY - JOUR

T1 - Epigenetics and cardiovascular development

AU - Chang, Ching-Pin

AU - Bruneau, Benoit G.

PY - 2012

Y1 - 2012

N2 - The cardiovascular system is broadly composed of the heart, which pumps blood, and the blood vessels, which carry blood to and from tissues of the body. Heart malformations are the most serious common birth defect, affecting at least 2% of newborns and leading to significant morbidity and mortality. Severe heart malformations cause heart failure in fetuses, infants, and children, whereas milder heart defects may not trigger significant heart dysfunction until early or midadulthood. Severe vasculogenesis or angiogenesis defects in embryos are incompatible with life, and anomalous arterial patterning may cause vascular aberrancies that often require surgical treatment. It is therefore important to understand the underlying mechanisms that control cardiovascular development. Understanding developmental mechanisms will also help us design better strategies to regenerate cardiovascular tissues for therapeutic purposes. An important mechanism regulating genes involves the modification of chromatin, the higher-order structure in which DNA is packaged. Recent studies have greatly expanded our understanding of the regulation of cardiovascular development at the chromatin level, including the remodeling of chromatin and the modification of histones. Chromatin-level regulation integrates multiple inputs and coordinates broad gene expression programs. Thus, understanding chromatin-level regulation will allow for a better appreciation of gene regulation as a whole and may set a fundamental basis for cardiovascular disease. This review focuses on how chromatin-remodeling and histone-modifying factors regulate gene expression to control cardiovascular development.

AB - The cardiovascular system is broadly composed of the heart, which pumps blood, and the blood vessels, which carry blood to and from tissues of the body. Heart malformations are the most serious common birth defect, affecting at least 2% of newborns and leading to significant morbidity and mortality. Severe heart malformations cause heart failure in fetuses, infants, and children, whereas milder heart defects may not trigger significant heart dysfunction until early or midadulthood. Severe vasculogenesis or angiogenesis defects in embryos are incompatible with life, and anomalous arterial patterning may cause vascular aberrancies that often require surgical treatment. It is therefore important to understand the underlying mechanisms that control cardiovascular development. Understanding developmental mechanisms will also help us design better strategies to regenerate cardiovascular tissues for therapeutic purposes. An important mechanism regulating genes involves the modification of chromatin, the higher-order structure in which DNA is packaged. Recent studies have greatly expanded our understanding of the regulation of cardiovascular development at the chromatin level, including the remodeling of chromatin and the modification of histones. Chromatin-level regulation integrates multiple inputs and coordinates broad gene expression programs. Thus, understanding chromatin-level regulation will allow for a better appreciation of gene regulation as a whole and may set a fundamental basis for cardiovascular disease. This review focuses on how chromatin-remodeling and histone-modifying factors regulate gene expression to control cardiovascular development.

KW - Chromatin remodeling

KW - Congenital heart disease

KW - Gene expression

KW - Histone modification

KW - Vascular disease

UR - http://www.scopus.com/inward/record.url?scp=84863149111&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863149111&partnerID=8YFLogxK

U2 - 10.1146/annurev-physiol-020911-153242

DO - 10.1146/annurev-physiol-020911-153242

M3 - Article

C2 - 22035349

AN - SCOPUS:84863149111

VL - 74

SP - 41

EP - 68

JO - Annual Review of Physiology

JF - Annual Review of Physiology

SN - 0066-4278

ER -