Epilepsy surgery improves regional glucose metabolism on PET scan - A case report

Richard M. Dasheiff, John Rosenbek, Charles Matthews, Robert J. Nickles, Robert A. Koeppe, Gary Hutchins, Lincoln Ramirez, LaVera Dickinson

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A patient with medically intractable complex partial epilepsy was evaluated for epilepsy surgery by electroencephalograph recording with depth electrodes and 18F-fluorodeoxyglucose positron emission tomography (PET). A small calcified arteriovenous malformation was excised from the left parietal lobe, and the patient became seizure free. Baseline and language stimulation PET scans were obtained preoperatively and 10 months postoperatively. There was a significant increase in glucose metabolism of the left temporal lobe postoperatively, which we interpret as evidence of improved neuronal function. We suggest that this case represents evidence for a functional, and reversible, inhibition of neuronal metabolism by epileptic activity.

Original languageEnglish (US)
Pages (from-to)283-288
Number of pages6
JournalJournal of Neurology
Volume234
Issue number5
DOIs
StatePublished - Jun 1987
Externally publishedYes

Fingerprint

Positron-Emission Tomography
Epilepsy
Complex Partial Epilepsy
Glucose
Parietal Lobe
Arteriovenous Malformations
Fluorodeoxyglucose F18
Temporal Lobe
Electrodes
Seizures
Language
Inhibition (Psychology)

Keywords

  • 2-Deoxyglucose
  • Complex partial epilepsy
  • Epilepsy surgery
  • Positron emission tomography

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Dasheiff, R. M., Rosenbek, J., Matthews, C., Nickles, R. J., Koeppe, R. A., Hutchins, G., ... Dickinson, L. (1987). Epilepsy surgery improves regional glucose metabolism on PET scan - A case report. Journal of Neurology, 234(5), 283-288. https://doi.org/10.1007/BF00314281

Epilepsy surgery improves regional glucose metabolism on PET scan - A case report. / Dasheiff, Richard M.; Rosenbek, John; Matthews, Charles; Nickles, Robert J.; Koeppe, Robert A.; Hutchins, Gary; Ramirez, Lincoln; Dickinson, LaVera.

In: Journal of Neurology, Vol. 234, No. 5, 06.1987, p. 283-288.

Research output: Contribution to journalArticle

Dasheiff, RM, Rosenbek, J, Matthews, C, Nickles, RJ, Koeppe, RA, Hutchins, G, Ramirez, L & Dickinson, L 1987, 'Epilepsy surgery improves regional glucose metabolism on PET scan - A case report', Journal of Neurology, vol. 234, no. 5, pp. 283-288. https://doi.org/10.1007/BF00314281
Dasheiff, Richard M. ; Rosenbek, John ; Matthews, Charles ; Nickles, Robert J. ; Koeppe, Robert A. ; Hutchins, Gary ; Ramirez, Lincoln ; Dickinson, LaVera. / Epilepsy surgery improves regional glucose metabolism on PET scan - A case report. In: Journal of Neurology. 1987 ; Vol. 234, No. 5. pp. 283-288.
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