Epithelial hyperplasia in human polycystic kidney diseases. Its role in pathogenesis and risk of neoplasia

J. Bernstein, Andrew Evan, K. D. Gardner

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

The importance of tubular epithelial hyperplasia in polycystic kidney diseases has become apparent during the last decade. Micropapillary hyperplasia occurs in autosomal dominant polycystic kidney disease, in localized cystic disease, and in acquired cystic disease. Neoplastic or severely dysplastic epithelial hyperplasia occurs in von Hippel-Lindau disease. A histopathologically distinctive epithelial hyperplasia occurs in tuberous sclerosis. In each of these conditions, epithelial hyperplasia may be related to cyst formation and may also impose an increased risk of malignancy - a risk that seems to be highest in patients under treatment with long-term hemodialysis for end-stage kidney disease. Although hyperplasia in some of these diseases may share a common pathway of development, it is more probable that the histopathologic differences reflect different pathogenetic pathways that converge on a common endpoint.

Original languageEnglish (US)
Pages (from-to)92-101
Number of pages10
JournalAmerican Journal of Pathology
Volume129
Issue number1
StatePublished - 1987
Externally publishedYes

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Polycystic Kidney Diseases
Hyperplasia
Neoplasms
von Hippel-Lindau Disease
Autosomal Dominant Polycystic Kidney
Tuberous Sclerosis
Chronic Kidney Failure
Renal Dialysis
Cysts

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Epithelial hyperplasia in human polycystic kidney diseases. Its role in pathogenesis and risk of neoplasia. / Bernstein, J.; Evan, Andrew; Gardner, K. D.

In: American Journal of Pathology, Vol. 129, No. 1, 1987, p. 92-101.

Research output: Contribution to journalArticle

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