Epithelial sheath neuroma

Evidence supporting a hyperplastic etiology and epidermal origin

Stefanie A. Hirano-Ali, Elizabeth A. Bryant, Simon Warren

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

An epithelial sheath neuroma (ESN) is a rare benign process of unknown pathogenesis, which is characterized histologically by multiple enlarged peripheral nerve fibers ensheathed by mature squamous epithelium. The histologic features can elicit concern for carcinomatous perineural invasion. The process is limited to the superficial dermis and is surrounded by a loose myxoid stroma, lymphocytic infiltrate and sometimes prominent infundibular cysts. The etiology of this peculiar entity has been debated and theories include a benign neoplasm, a hamartoma or an unusual reactive hyperplasia. There are only seven prior cases reported of ESN in the literature. Our case presented here is the first report to show connection of the ESN to the overlying epidermis and reactive epidermal hyperplasia. This suggests that ESN is indeed an unusual form of benign reactive hyperplasia. In addition, the clinical setting in this case was of pruritus and scratching in a background of papular urticaria, supporting the previous notion that ESN is probably a response to an external stimulus such as rubbing.

Original languageEnglish (US)
JournalJournal of Cutaneous Pathology
DOIs
StateAccepted/In press - 2016

Fingerprint

Neuroma
Hyperplasia
Hamartoma
Pruritus
Dermis
Peripheral Nerves
Nerve Fibers
Epidermis
Cysts
Neoplasms
Epithelium

Keywords

  • Atypical features
  • Dermatopathology
  • Pseudomalignancy

ASJC Scopus subject areas

  • Dermatology
  • Pathology and Forensic Medicine
  • Histology

Cite this

Epithelial sheath neuroma : Evidence supporting a hyperplastic etiology and epidermal origin. / Hirano-Ali, Stefanie A.; Bryant, Elizabeth A.; Warren, Simon.

In: Journal of Cutaneous Pathology, 2016.

Research output: Contribution to journalArticle

@article{65c989c953a7445aad4796fb13687b0b,
title = "Epithelial sheath neuroma: Evidence supporting a hyperplastic etiology and epidermal origin",
abstract = "An epithelial sheath neuroma (ESN) is a rare benign process of unknown pathogenesis, which is characterized histologically by multiple enlarged peripheral nerve fibers ensheathed by mature squamous epithelium. The histologic features can elicit concern for carcinomatous perineural invasion. The process is limited to the superficial dermis and is surrounded by a loose myxoid stroma, lymphocytic infiltrate and sometimes prominent infundibular cysts. The etiology of this peculiar entity has been debated and theories include a benign neoplasm, a hamartoma or an unusual reactive hyperplasia. There are only seven prior cases reported of ESN in the literature. Our case presented here is the first report to show connection of the ESN to the overlying epidermis and reactive epidermal hyperplasia. This suggests that ESN is indeed an unusual form of benign reactive hyperplasia. In addition, the clinical setting in this case was of pruritus and scratching in a background of papular urticaria, supporting the previous notion that ESN is probably a response to an external stimulus such as rubbing.",
keywords = "Atypical features, Dermatopathology, Pseudomalignancy",
author = "Hirano-Ali, {Stefanie A.} and Bryant, {Elizabeth A.} and Simon Warren",
year = "2016",
doi = "10.1111/cup.12693",
language = "English (US)",
journal = "Journal of Cutaneous Pathology",
issn = "0303-6987",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Epithelial sheath neuroma

T2 - Evidence supporting a hyperplastic etiology and epidermal origin

AU - Hirano-Ali, Stefanie A.

AU - Bryant, Elizabeth A.

AU - Warren, Simon

PY - 2016

Y1 - 2016

N2 - An epithelial sheath neuroma (ESN) is a rare benign process of unknown pathogenesis, which is characterized histologically by multiple enlarged peripheral nerve fibers ensheathed by mature squamous epithelium. The histologic features can elicit concern for carcinomatous perineural invasion. The process is limited to the superficial dermis and is surrounded by a loose myxoid stroma, lymphocytic infiltrate and sometimes prominent infundibular cysts. The etiology of this peculiar entity has been debated and theories include a benign neoplasm, a hamartoma or an unusual reactive hyperplasia. There are only seven prior cases reported of ESN in the literature. Our case presented here is the first report to show connection of the ESN to the overlying epidermis and reactive epidermal hyperplasia. This suggests that ESN is indeed an unusual form of benign reactive hyperplasia. In addition, the clinical setting in this case was of pruritus and scratching in a background of papular urticaria, supporting the previous notion that ESN is probably a response to an external stimulus such as rubbing.

AB - An epithelial sheath neuroma (ESN) is a rare benign process of unknown pathogenesis, which is characterized histologically by multiple enlarged peripheral nerve fibers ensheathed by mature squamous epithelium. The histologic features can elicit concern for carcinomatous perineural invasion. The process is limited to the superficial dermis and is surrounded by a loose myxoid stroma, lymphocytic infiltrate and sometimes prominent infundibular cysts. The etiology of this peculiar entity has been debated and theories include a benign neoplasm, a hamartoma or an unusual reactive hyperplasia. There are only seven prior cases reported of ESN in the literature. Our case presented here is the first report to show connection of the ESN to the overlying epidermis and reactive epidermal hyperplasia. This suggests that ESN is indeed an unusual form of benign reactive hyperplasia. In addition, the clinical setting in this case was of pruritus and scratching in a background of papular urticaria, supporting the previous notion that ESN is probably a response to an external stimulus such as rubbing.

KW - Atypical features

KW - Dermatopathology

KW - Pseudomalignancy

UR - http://www.scopus.com/inward/record.url?scp=84962867024&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84962867024&partnerID=8YFLogxK

U2 - 10.1111/cup.12693

DO - 10.1111/cup.12693

M3 - Article

JO - Journal of Cutaneous Pathology

JF - Journal of Cutaneous Pathology

SN - 0303-6987

ER -