Epithelial to Mesenchymal Transition in Renal Cell Carcinoma: Implications for Cancer Therapy

Francesco Piva, Matteo Giulietti, Matteo Santoni, Giulia Occhipinti, Marina Scarpelli, Antonio Lopez-Beltran, Liang Cheng, Giovanni Principato, Rodolfo Montironi

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Epithelial-to-mesenchymal transition (EMT) is a developmentally vital reversible process by which fully differentiated cells lose their epithelial features and acquire a migratory mesenchymal phenotype. EMT contributes to the metastatic potential of tumors. The expression profile and other biological properties of EMT suggest potential targets for cancer therapy, including in renal-cell carcinoma (RCC). The preclinical and clinical results have substantiated the promises that dysregulated elements leading to EMT can be a potential target in RCC patients. In this study, we illustrated the pathogenic and prognostic role of EMT in RCC. In addition, we reconstructed, by literature analysis, the different pathways implicated in the EMT process, thus supporting the rational for future EMT-directed therapeutic approaches for RCC patients.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalMolecular Diagnosis and Therapy
DOIs
StateAccepted/In press - Mar 3 2016

ASJC Scopus subject areas

  • Genetics
  • Molecular Medicine
  • Medicine(all)
  • Pharmacology

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    Piva, F., Giulietti, M., Santoni, M., Occhipinti, G., Scarpelli, M., Lopez-Beltran, A., Cheng, L., Principato, G., & Montironi, R. (Accepted/In press). Epithelial to Mesenchymal Transition in Renal Cell Carcinoma: Implications for Cancer Therapy. Molecular Diagnosis and Therapy, 1-7. https://doi.org/10.1007/s40291-016-0192-5