Erosion Remineralization Efficacy of Gel-to-Foam Fluoride Toothpastes in situ: A Randomized Clinical Trial

Marc Nehme, Peter Jeffery, Stephen Mason, Frank Lippert, Domenick Zero, Anderson Hara

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

This single-center, randomized, placebo-controlled, four-treatment, four-period crossover study compared the enamel remineralization effects of low- and medium-abrasivity gel-to-foam toothpastes and a reference toothpaste (all 1,450 ppm fluoride as NaF) versus placebo toothpaste (0 ppm fluoride) using a short-term in situ erosion model. Subjects (n = 56) wearing a palatal appliance holding acid-softened bovine enamel specimens brushed their teeth with the test toothpastes. Thereafter, the specimens were removed for analysis of percent surface microhardness recovery (%SMHR) and percent relative erosion resistance (%RER) at 2, 4, and 8 h. Both low- and medium-abrasivity gel-to-foam fluoride toothpastes and the reference toothpaste provided significantly greater %SMHR than placebo at all assessment time points (all p <0.05). No statistically significant difference of %SMHR was observed between the fluoride treatment groups at any time point. Similarly, all fluoride products provided significantly superior %RER versus placebo (all p <0.0001), whereas no significant difference of this parameter was noted between the fluoride treatment groups. Increasing numerical improvements of %SMHR and %RER were observed in all four treatment groups over time (2, 4, and 8 h). The present in situ model is a sensitive tool to investigate intrinsic and fluoride-enhanced rehardening of eroded enamel. All three fluoride toothpastes were more efficacious than placebo, and there were no safety concerns following single dosing in this short-term in situ model.

Original languageEnglish (US)
Pages (from-to)62-70
Number of pages9
JournalCaries Research
DOIs
StateAccepted/In press - Feb 11 2016

Fingerprint

Toothpastes
Fluorides
Randomized Controlled Trials
Gels
Placebos
Dental Enamel
Therapeutics
Cross-Over Studies
Tooth
Safety
Acids

Keywords

  • Dental erosion
  • Fluoride
  • Gel-to-foam toothpaste
  • In situ model
  • Surface microhardness#

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Erosion Remineralization Efficacy of Gel-to-Foam Fluoride Toothpastes in situ : A Randomized Clinical Trial. / Nehme, Marc; Jeffery, Peter; Mason, Stephen; Lippert, Frank; Zero, Domenick; Hara, Anderson.

In: Caries Research, 11.02.2016, p. 62-70.

Research output: Contribution to journalArticle

@article{ea15c28e4d5a411290a687470deded85,
title = "Erosion Remineralization Efficacy of Gel-to-Foam Fluoride Toothpastes in situ: A Randomized Clinical Trial",
abstract = "This single-center, randomized, placebo-controlled, four-treatment, four-period crossover study compared the enamel remineralization effects of low- and medium-abrasivity gel-to-foam toothpastes and a reference toothpaste (all 1,450 ppm fluoride as NaF) versus placebo toothpaste (0 ppm fluoride) using a short-term in situ erosion model. Subjects (n = 56) wearing a palatal appliance holding acid-softened bovine enamel specimens brushed their teeth with the test toothpastes. Thereafter, the specimens were removed for analysis of percent surface microhardness recovery ({\%}SMHR) and percent relative erosion resistance ({\%}RER) at 2, 4, and 8 h. Both low- and medium-abrasivity gel-to-foam fluoride toothpastes and the reference toothpaste provided significantly greater {\%}SMHR than placebo at all assessment time points (all p <0.05). No statistically significant difference of {\%}SMHR was observed between the fluoride treatment groups at any time point. Similarly, all fluoride products provided significantly superior {\%}RER versus placebo (all p <0.0001), whereas no significant difference of this parameter was noted between the fluoride treatment groups. Increasing numerical improvements of {\%}SMHR and {\%}RER were observed in all four treatment groups over time (2, 4, and 8 h). The present in situ model is a sensitive tool to investigate intrinsic and fluoride-enhanced rehardening of eroded enamel. All three fluoride toothpastes were more efficacious than placebo, and there were no safety concerns following single dosing in this short-term in situ model.",
keywords = "Dental erosion, Fluoride, Gel-to-foam toothpaste, In situ model, Surface microhardness#",
author = "Marc Nehme and Peter Jeffery and Stephen Mason and Frank Lippert and Domenick Zero and Anderson Hara",
year = "2016",
month = "2",
day = "11",
doi = "10.1159/000443187",
language = "English (US)",
pages = "62--70",
journal = "Caries Research",
issn = "0008-6568",
publisher = "S. Karger AG",

}

TY - JOUR

T1 - Erosion Remineralization Efficacy of Gel-to-Foam Fluoride Toothpastes in situ

T2 - A Randomized Clinical Trial

AU - Nehme, Marc

AU - Jeffery, Peter

AU - Mason, Stephen

AU - Lippert, Frank

AU - Zero, Domenick

AU - Hara, Anderson

PY - 2016/2/11

Y1 - 2016/2/11

N2 - This single-center, randomized, placebo-controlled, four-treatment, four-period crossover study compared the enamel remineralization effects of low- and medium-abrasivity gel-to-foam toothpastes and a reference toothpaste (all 1,450 ppm fluoride as NaF) versus placebo toothpaste (0 ppm fluoride) using a short-term in situ erosion model. Subjects (n = 56) wearing a palatal appliance holding acid-softened bovine enamel specimens brushed their teeth with the test toothpastes. Thereafter, the specimens were removed for analysis of percent surface microhardness recovery (%SMHR) and percent relative erosion resistance (%RER) at 2, 4, and 8 h. Both low- and medium-abrasivity gel-to-foam fluoride toothpastes and the reference toothpaste provided significantly greater %SMHR than placebo at all assessment time points (all p <0.05). No statistically significant difference of %SMHR was observed between the fluoride treatment groups at any time point. Similarly, all fluoride products provided significantly superior %RER versus placebo (all p <0.0001), whereas no significant difference of this parameter was noted between the fluoride treatment groups. Increasing numerical improvements of %SMHR and %RER were observed in all four treatment groups over time (2, 4, and 8 h). The present in situ model is a sensitive tool to investigate intrinsic and fluoride-enhanced rehardening of eroded enamel. All three fluoride toothpastes were more efficacious than placebo, and there were no safety concerns following single dosing in this short-term in situ model.

AB - This single-center, randomized, placebo-controlled, four-treatment, four-period crossover study compared the enamel remineralization effects of low- and medium-abrasivity gel-to-foam toothpastes and a reference toothpaste (all 1,450 ppm fluoride as NaF) versus placebo toothpaste (0 ppm fluoride) using a short-term in situ erosion model. Subjects (n = 56) wearing a palatal appliance holding acid-softened bovine enamel specimens brushed their teeth with the test toothpastes. Thereafter, the specimens were removed for analysis of percent surface microhardness recovery (%SMHR) and percent relative erosion resistance (%RER) at 2, 4, and 8 h. Both low- and medium-abrasivity gel-to-foam fluoride toothpastes and the reference toothpaste provided significantly greater %SMHR than placebo at all assessment time points (all p <0.05). No statistically significant difference of %SMHR was observed between the fluoride treatment groups at any time point. Similarly, all fluoride products provided significantly superior %RER versus placebo (all p <0.0001), whereas no significant difference of this parameter was noted between the fluoride treatment groups. Increasing numerical improvements of %SMHR and %RER were observed in all four treatment groups over time (2, 4, and 8 h). The present in situ model is a sensitive tool to investigate intrinsic and fluoride-enhanced rehardening of eroded enamel. All three fluoride toothpastes were more efficacious than placebo, and there were no safety concerns following single dosing in this short-term in situ model.

KW - Dental erosion

KW - Fluoride

KW - Gel-to-foam toothpaste

KW - In situ model

KW - Surface microhardness#

UR - http://www.scopus.com/inward/record.url?scp=84957927942&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84957927942&partnerID=8YFLogxK

U2 - 10.1159/000443187

DO - 10.1159/000443187

M3 - Article

C2 - 26862746

AN - SCOPUS:84957927942

SP - 62

EP - 70

JO - Caries Research

JF - Caries Research

SN - 0008-6568

ER -