Errors in bone remodeling: Toward a unified theory of metabolic bone disease

David Burr, R. B. Martin

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

Recent evidence suggests that skeletal adaptation is organized by a functional unit that includes cells of diverse origin working in coordination. Genetic and metabolic factors control and regulate the processes of modeling and remodeling, only rarely acting on the isolated individual functions of specific cell lines. Errors in the genetic or metabolic regulation of the functional unit affect the entire process of skeletal adaptation rather than specific elements of it. Viewed in this way, some metabolic bone diseases can be understood as relatively simple errors in factors that control the coordinate activities of the entire functional unit. This paper reviews the modeling and remodeling processes and demonstrates how abnormal morphological characteristics of bone tissue can be viewed as products of specific errors in the adaptive process.

Original languageEnglish (US)
Pages (from-to)186-216
Number of pages31
JournalAmerican Journal of Anatomy
Volume186
Issue number2
StatePublished - 1989
Externally publishedYes

Fingerprint

Bone Remodeling
Metabolic Bone Diseases
Bone and Bones
Cell Line

ASJC Scopus subject areas

  • Anatomy

Cite this

Errors in bone remodeling : Toward a unified theory of metabolic bone disease. / Burr, David; Martin, R. B.

In: American Journal of Anatomy, Vol. 186, No. 2, 1989, p. 186-216.

Research output: Contribution to journalArticle

Burr, David ; Martin, R. B. / Errors in bone remodeling : Toward a unified theory of metabolic bone disease. In: American Journal of Anatomy. 1989 ; Vol. 186, No. 2. pp. 186-216.
@article{e6e082797eca480a8001070d110e0cc2,
title = "Errors in bone remodeling: Toward a unified theory of metabolic bone disease",
abstract = "Recent evidence suggests that skeletal adaptation is organized by a functional unit that includes cells of diverse origin working in coordination. Genetic and metabolic factors control and regulate the processes of modeling and remodeling, only rarely acting on the isolated individual functions of specific cell lines. Errors in the genetic or metabolic regulation of the functional unit affect the entire process of skeletal adaptation rather than specific elements of it. Viewed in this way, some metabolic bone diseases can be understood as relatively simple errors in factors that control the coordinate activities of the entire functional unit. This paper reviews the modeling and remodeling processes and demonstrates how abnormal morphological characteristics of bone tissue can be viewed as products of specific errors in the adaptive process.",
author = "David Burr and Martin, {R. B.}",
year = "1989",
language = "English (US)",
volume = "186",
pages = "186--216",
journal = "Developmental Dynamics",
issn = "1058-8388",
publisher = "Wiley-Liss Inc.",
number = "2",

}

TY - JOUR

T1 - Errors in bone remodeling

T2 - Toward a unified theory of metabolic bone disease

AU - Burr, David

AU - Martin, R. B.

PY - 1989

Y1 - 1989

N2 - Recent evidence suggests that skeletal adaptation is organized by a functional unit that includes cells of diverse origin working in coordination. Genetic and metabolic factors control and regulate the processes of modeling and remodeling, only rarely acting on the isolated individual functions of specific cell lines. Errors in the genetic or metabolic regulation of the functional unit affect the entire process of skeletal adaptation rather than specific elements of it. Viewed in this way, some metabolic bone diseases can be understood as relatively simple errors in factors that control the coordinate activities of the entire functional unit. This paper reviews the modeling and remodeling processes and demonstrates how abnormal morphological characteristics of bone tissue can be viewed as products of specific errors in the adaptive process.

AB - Recent evidence suggests that skeletal adaptation is organized by a functional unit that includes cells of diverse origin working in coordination. Genetic and metabolic factors control and regulate the processes of modeling and remodeling, only rarely acting on the isolated individual functions of specific cell lines. Errors in the genetic or metabolic regulation of the functional unit affect the entire process of skeletal adaptation rather than specific elements of it. Viewed in this way, some metabolic bone diseases can be understood as relatively simple errors in factors that control the coordinate activities of the entire functional unit. This paper reviews the modeling and remodeling processes and demonstrates how abnormal morphological characteristics of bone tissue can be viewed as products of specific errors in the adaptive process.

UR - http://www.scopus.com/inward/record.url?scp=0024422901&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024422901&partnerID=8YFLogxK

M3 - Article

C2 - 2683714

AN - SCOPUS:0024422901

VL - 186

SP - 186

EP - 216

JO - Developmental Dynamics

JF - Developmental Dynamics

SN - 1058-8388

IS - 2

ER -