Erythropoiesis and Hyperoxia

J. W. Fletcher, N. I. Gallagher, M. A. Warnecke, R. M. Donati

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Exposure to a 50% oxygen environment produced a decrease in erythropoiesis which was paralleled by a decrease in plasma erythropoietic stimulating activity. Similar results were obtained following exposure to a 100% oxygen environment. Marrow depression produced by hyperoxia could be reversed by erythropoietic stimulants. The suppression of erythropoiesis in both partners of parabiots maintained so that one breathed 20% and the other 90-95% oxygen suggests that a humoral inhibitor is produced in the hyperoxic animal and supports the hypothesis that erythropoiesis is regulated by the dynamic interaction of erythropoietin and an erythropoietic inhibitor.

Original languageEnglish (US)
Pages (from-to)569-574
Number of pages6
JournalProceedings of the Society for Experimental Biology and Medicine
Volume144
Issue number2
DOIs
StatePublished - Nov 1973
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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