Esophageal dilation

Simple and effective treatment for adults with eosinophilic esophagitis and esophageal rings and narrowing

Matthew Bohm, J. E. Richter, S. Kelsen, R. Thomas

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

The goal of this article is to present the results of the long-term treatment with esophageal dilation of a consecutive series of adults with eosinophilic esophagitis (EoE). EoE in adults is a disease of middle aged white males, with recurrent food impactions and dysphagia. The exact treatment of EoE is unknown due to the uncertainty of the pathogenesis. Currently, the long-term follow-up of adult EoE patients is limited. Sixteen consecutive adult patients (12 males/4 females between ages 27 and 58 years) with EoE underwent a detailed history and baseline upper gastrointestinal endoscopy (EGD) with multiple esophageal biopsies. Thirteen had esophageal dilation. Fifteen were on proton pump inhibitor (PPI) therapy. After dilation, one patient was treated with a restrictive diet. One patient took prn fluticasone. Most of the patients had allergy testing for food and aeroallergens. Follow-up evaluation with similar testing was on average 22 months (range: 12-40 months). Six patients were not available for follow-up. None of the remaining 10 patients had a food impaction; one required further esophageal dilation. Only two patients had intermittent dysphagia. The average dysphagia score decreased from 2.1 to 0.3 (P < 0.002). The average number of eosinophils at follow-up was not significantly different from baseline (120 eosinophils/HPF proximally and 165 eosinophils/HPF distally (P = 0.75). The gross endoscopy findings were unchanged in all patients except one who normalized. A total of 62% and 75% of patients had positive tests for aeroallergens and food allergens, respectively. Over an average of two years, esophageal dilation provided excellent symptomatic relief among 10 adult EoE patients despite no improvement in the mucosal eosinophilia or gross endoscopic appearance.

Original languageEnglish (US)
Pages (from-to)377-385
Number of pages9
JournalDiseases of the Esophagus
Volume23
Issue number5
DOIs
StatePublished - Jul 2010
Externally publishedYes

Fingerprint

Eosinophilic Esophagitis
Dilatation
Deglutition Disorders
Eosinophils
Therapeutics
Food
Gastrointestinal Endoscopy
Food Hypersensitivity
Proton Pump Inhibitors
Eosinophilia
Allergens
Endoscopy
Uncertainty

Keywords

  • Dysphagia
  • Eosinophilic esophagitis
  • Esophageal dilation
  • Ringed esophagus

ASJC Scopus subject areas

  • Gastroenterology
  • Medicine(all)

Cite this

Esophageal dilation : Simple and effective treatment for adults with eosinophilic esophagitis and esophageal rings and narrowing. / Bohm, Matthew; Richter, J. E.; Kelsen, S.; Thomas, R.

In: Diseases of the Esophagus, Vol. 23, No. 5, 07.2010, p. 377-385.

Research output: Contribution to journalArticle

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