Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant

W. C. Earnshaw, R. C. Allshire, B. E. Black, K. Bloom, B. R. Brinkley, W. Brown, I. M. Cheeseman, K. H.A. Choo, G. P. Copenhaver, J. G. Deluca, A. Desai, S. Diekmann, S. Erhardt, M. Fitzgerald-Hayes, D. Foltz, T. Fukagawa, R. Gassmann, D. W. Gerlich, D. M. Glover, G. J. GorbskyS. C. Harrison, P. Heun, T. Hirota, L. E.T. Jansen, G. Karpen, G. J.P.L. Kops, M. A. Lampson, S. M. Lens, A. Losada, K. Luger, H. Maiato, P. S. Maddox, R. L. Margolis, H. Masumoto, A. D. McAinsh, B. G. Mellone, P. Meraldi, A. Musacchio, K. Oegema, R. J. O'Neill, E. D. Salmon, K. C. Scott, A. F. Straight, P. T. Stukenberg, B. A. Sullivan, K. F. Sullivan, C. E. Sunkel, J. R. Swedlow, C. E. Walczak, P. E. Warburton, S. Westermann, H. F. Willard, L. Wordeman, M. Yanagida, T. J. Yen, K. Yoda, D. W. Cleveland

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease. It has recently been suggested to rename this protein CenH3. Here, we argue that the original name should be maintained both because it is the basis of a long established nomenclature for centromere proteins and because it avoids confusion due to the presence of canonical histone H3 at centromeres.

Original languageEnglish (US)
Pages (from-to)101-106
Number of pages6
JournalChromosome Research
Volume21
Issue number2
DOIs
StatePublished - Apr 1 2013

Fingerprint

Histones
Centromere
Proteins
Terminology
Autoantibodies
Names
centromere protein A

Keywords

  • CenH3
  • CENP-A
  • centromere
  • histone
  • kinetochore

ASJC Scopus subject areas

  • Genetics

Cite this

Earnshaw, W. C., Allshire, R. C., Black, B. E., Bloom, K., Brinkley, B. R., Brown, W., ... Cleveland, D. W. (2013). Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant. Chromosome Research, 21(2), 101-106. https://doi.org/10.1007/s10577-013-9347-y

Esperanto for histones : CENP-A, not CenH3, is the centromeric histone H3 variant. / Earnshaw, W. C.; Allshire, R. C.; Black, B. E.; Bloom, K.; Brinkley, B. R.; Brown, W.; Cheeseman, I. M.; Choo, K. H.A.; Copenhaver, G. P.; Deluca, J. G.; Desai, A.; Diekmann, S.; Erhardt, S.; Fitzgerald-Hayes, M.; Foltz, D.; Fukagawa, T.; Gassmann, R.; Gerlich, D. W.; Glover, D. M.; Gorbsky, G. J.; Harrison, S. C.; Heun, P.; Hirota, T.; Jansen, L. E.T.; Karpen, G.; Kops, G. J.P.L.; Lampson, M. A.; Lens, S. M.; Losada, A.; Luger, K.; Maiato, H.; Maddox, P. S.; Margolis, R. L.; Masumoto, H.; McAinsh, A. D.; Mellone, B. G.; Meraldi, P.; Musacchio, A.; Oegema, K.; O'Neill, R. J.; Salmon, E. D.; Scott, K. C.; Straight, A. F.; Stukenberg, P. T.; Sullivan, B. A.; Sullivan, K. F.; Sunkel, C. E.; Swedlow, J. R.; Walczak, C. E.; Warburton, P. E.; Westermann, S.; Willard, H. F.; Wordeman, L.; Yanagida, M.; Yen, T. J.; Yoda, K.; Cleveland, D. W.

In: Chromosome Research, Vol. 21, No. 2, 01.04.2013, p. 101-106.

Research output: Contribution to journalArticle

Earnshaw, WC, Allshire, RC, Black, BE, Bloom, K, Brinkley, BR, Brown, W, Cheeseman, IM, Choo, KHA, Copenhaver, GP, Deluca, JG, Desai, A, Diekmann, S, Erhardt, S, Fitzgerald-Hayes, M, Foltz, D, Fukagawa, T, Gassmann, R, Gerlich, DW, Glover, DM, Gorbsky, GJ, Harrison, SC, Heun, P, Hirota, T, Jansen, LET, Karpen, G, Kops, GJPL, Lampson, MA, Lens, SM, Losada, A, Luger, K, Maiato, H, Maddox, PS, Margolis, RL, Masumoto, H, McAinsh, AD, Mellone, BG, Meraldi, P, Musacchio, A, Oegema, K, O'Neill, RJ, Salmon, ED, Scott, KC, Straight, AF, Stukenberg, PT, Sullivan, BA, Sullivan, KF, Sunkel, CE, Swedlow, JR, Walczak, CE, Warburton, PE, Westermann, S, Willard, HF, Wordeman, L, Yanagida, M, Yen, TJ, Yoda, K & Cleveland, DW 2013, 'Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant', Chromosome Research, vol. 21, no. 2, pp. 101-106. https://doi.org/10.1007/s10577-013-9347-y
Earnshaw WC, Allshire RC, Black BE, Bloom K, Brinkley BR, Brown W et al. Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant. Chromosome Research. 2013 Apr 1;21(2):101-106. https://doi.org/10.1007/s10577-013-9347-y
Earnshaw, W. C. ; Allshire, R. C. ; Black, B. E. ; Bloom, K. ; Brinkley, B. R. ; Brown, W. ; Cheeseman, I. M. ; Choo, K. H A ; Copenhaver, G. P. ; Deluca, J. G. ; Desai, A. ; Diekmann, S. ; Erhardt, S. ; Fitzgerald-Hayes, M. ; Foltz, D. ; Fukagawa, T. ; Gassmann, R. ; Gerlich, D. W. ; Glover, D. M. ; Gorbsky, G. J. ; Harrison, S. C. ; Heun, P. ; Hirota, T. ; Jansen, L. E T ; Karpen, G. ; Kops, G. J P L ; Lampson, M. A. ; Lens, S. M. ; Losada, A. ; Luger, K. ; Maiato, H. ; Maddox, P. S. ; Margolis, R. L. ; Masumoto, H. ; McAinsh, A. D. ; Mellone, B. G. ; Meraldi, P. ; Musacchio, A. ; Oegema, K. ; O'Neill, R. J. ; Salmon, E. D. ; Scott, K. C. ; Straight, A. F. ; Stukenberg, P. T. ; Sullivan, B. A. ; Sullivan, K. F. ; Sunkel, C. E. ; Swedlow, J. R. ; Walczak, Claire ; Warburton, P. E. ; Westermann, S. ; Willard, H. F. ; Wordeman, L. ; Yanagida, M. ; Yen, T. J. ; Yoda, K. ; Cleveland, D. W. / Esperanto for histones : CENP-A, not CenH3, is the centromeric histone H3 variant. In: Chromosome Research. 2013 ; Vol. 21, No. 2. pp. 101-106.
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AU - Allshire, R. C.

AU - Black, B. E.

AU - Bloom, K.

AU - Brinkley, B. R.

AU - Brown, W.

AU - Cheeseman, I. M.

AU - Choo, K. H.A.

AU - Copenhaver, G. P.

AU - Deluca, J. G.

AU - Desai, A.

AU - Diekmann, S.

AU - Erhardt, S.

AU - Fitzgerald-Hayes, M.

AU - Foltz, D.

AU - Fukagawa, T.

AU - Gassmann, R.

AU - Gerlich, D. W.

AU - Glover, D. M.

AU - Gorbsky, G. J.

AU - Harrison, S. C.

AU - Heun, P.

AU - Hirota, T.

AU - Jansen, L. E.T.

AU - Karpen, G.

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AU - Lampson, M. A.

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AU - McAinsh, A. D.

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AU - Warburton, P. E.

AU - Westermann, S.

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