Essential contribution of macrophages to islet cell destruction in vivo and in vitro

Hubert Kolb, Volker Burkart, Britta Appels, Helmut Hanenberg, Gudrun Kantwerk-Funke, Ulrich Kiesel, Jörg Funda, Ulrich Schraermeyer, Victora Kolb-Bachofen

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53 Scopus citations

Abstract

A number of observations indicate an essential role of macrophage activity in the development of hyperglycemia in animal models of Type I diabetes. Administration of macrophage-toxic silica particles prevents spontaneous diabetes development in BB rats or NOD mice. The same result was noted in the low-dose streptozotocin-induced diabetes model in mice. Macrophages appear to be the first immune cells infiltrating islets during early insulitis. Macrophages in inflamed islets of BB rats bear the EDI marker, whereas resident islet macrophages are ED2-positive. In vitro, EDl-positive macrophages were found to lyse pancreatic islet cells to a similar degree to various tumor cells but not normal thyrocytes. Macrophage-mediated lysis of islet cells was inhibited in the presence of 10-100 mM nicotinamide.

Original languageEnglish (US)
Pages (from-to)117-120
Number of pages4
JournalJournal of Autoimmunity
Volume3
DOIs
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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