Establishment of a clinically correlated human pericardial fluid bank: Evaluation of intrapericardial diagnostic potential

Tonya J. Dickson, Vivek Gurudutt, A. Q. Nguyen, K. Kumfer, W. Maxted, John Brown, Yousuf Mahomed, Thomas Sharp, Thomas X. Aufiero, Naomi Fineberg, Keith L. March

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The development of a clinically correlated human pericardial fluid bank and database is described. A unique feature of this registry is the availability of a large number of pericardial fluid samples for testing with respect to multiple factors and for correlation with angiographic findings and clinical syndromes expressed by the patients. The collection of data at the present time comprises frozen pericardial fluid samples obtained from patients who have undergone cardiac surgery; and historical, clinical, and laboratory data obtained from the patient records. Nearly 400 samples have been stored and analyzed thus far, with sample entry continuing. This registry is designed to evaluate the local factors that play a role in mediating or reflecting myocardial or coronary responses. Pathophysiologic processes of particular interest include restenosis, plaque ruptures, and angiogenesis. Study of the pericardial fluid bank should lead to enhanced understanding of molecular mechanisms, as well as to the explanation for the reasons underlying interpatient variability in these processes. It is further anticipated that this information might provide a foundation for the diagnostic use of pericardial fluid to individualize therapies targeting angiogenesis or plaque physiology.

Original languageEnglish
JournalClinical Cardiology
Volume22
Issue number1 SUPPL.
StatePublished - Jan 1999

Fingerprint

Registries
Thoracic Surgery
Rupture
Pericardial Fluid
Databases
Therapeutics

Keywords

  • Angiogenesis
  • Cytokines
  • Database
  • Growth factors
  • Pericardial fluid
  • Plaque stability
  • Registry

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Dickson, T. J., Gurudutt, V., Nguyen, A. Q., Kumfer, K., Maxted, W., Brown, J., ... March, K. L. (1999). Establishment of a clinically correlated human pericardial fluid bank: Evaluation of intrapericardial diagnostic potential. Clinical Cardiology, 22(1 SUPPL.).

Establishment of a clinically correlated human pericardial fluid bank : Evaluation of intrapericardial diagnostic potential. / Dickson, Tonya J.; Gurudutt, Vivek; Nguyen, A. Q.; Kumfer, K.; Maxted, W.; Brown, John; Mahomed, Yousuf; Sharp, Thomas; Aufiero, Thomas X.; Fineberg, Naomi; March, Keith L.

In: Clinical Cardiology, Vol. 22, No. 1 SUPPL., 01.1999.

Research output: Contribution to journalArticle

Dickson, TJ, Gurudutt, V, Nguyen, AQ, Kumfer, K, Maxted, W, Brown, J, Mahomed, Y, Sharp, T, Aufiero, TX, Fineberg, N & March, KL 1999, 'Establishment of a clinically correlated human pericardial fluid bank: Evaluation of intrapericardial diagnostic potential', Clinical Cardiology, vol. 22, no. 1 SUPPL..
Dickson, Tonya J. ; Gurudutt, Vivek ; Nguyen, A. Q. ; Kumfer, K. ; Maxted, W. ; Brown, John ; Mahomed, Yousuf ; Sharp, Thomas ; Aufiero, Thomas X. ; Fineberg, Naomi ; March, Keith L. / Establishment of a clinically correlated human pericardial fluid bank : Evaluation of intrapericardial diagnostic potential. In: Clinical Cardiology. 1999 ; Vol. 22, No. 1 SUPPL.
@article{8b84a3f6ce574e7f883eb9627a9a548d,
title = "Establishment of a clinically correlated human pericardial fluid bank: Evaluation of intrapericardial diagnostic potential",
abstract = "The development of a clinically correlated human pericardial fluid bank and database is described. A unique feature of this registry is the availability of a large number of pericardial fluid samples for testing with respect to multiple factors and for correlation with angiographic findings and clinical syndromes expressed by the patients. The collection of data at the present time comprises frozen pericardial fluid samples obtained from patients who have undergone cardiac surgery; and historical, clinical, and laboratory data obtained from the patient records. Nearly 400 samples have been stored and analyzed thus far, with sample entry continuing. This registry is designed to evaluate the local factors that play a role in mediating or reflecting myocardial or coronary responses. Pathophysiologic processes of particular interest include restenosis, plaque ruptures, and angiogenesis. Study of the pericardial fluid bank should lead to enhanced understanding of molecular mechanisms, as well as to the explanation for the reasons underlying interpatient variability in these processes. It is further anticipated that this information might provide a foundation for the diagnostic use of pericardial fluid to individualize therapies targeting angiogenesis or plaque physiology.",
keywords = "Angiogenesis, Cytokines, Database, Growth factors, Pericardial fluid, Plaque stability, Registry",
author = "Dickson, {Tonya J.} and Vivek Gurudutt and Nguyen, {A. Q.} and K. Kumfer and W. Maxted and John Brown and Yousuf Mahomed and Thomas Sharp and Aufiero, {Thomas X.} and Naomi Fineberg and March, {Keith L.}",
year = "1999",
month = "1",
language = "English",
volume = "22",
journal = "Clinical Cardiology",
issn = "0160-9289",
publisher = "John Wiley and Sons Inc.",
number = "1 SUPPL.",

}

TY - JOUR

T1 - Establishment of a clinically correlated human pericardial fluid bank

T2 - Evaluation of intrapericardial diagnostic potential

AU - Dickson, Tonya J.

AU - Gurudutt, Vivek

AU - Nguyen, A. Q.

AU - Kumfer, K.

AU - Maxted, W.

AU - Brown, John

AU - Mahomed, Yousuf

AU - Sharp, Thomas

AU - Aufiero, Thomas X.

AU - Fineberg, Naomi

AU - March, Keith L.

PY - 1999/1

Y1 - 1999/1

N2 - The development of a clinically correlated human pericardial fluid bank and database is described. A unique feature of this registry is the availability of a large number of pericardial fluid samples for testing with respect to multiple factors and for correlation with angiographic findings and clinical syndromes expressed by the patients. The collection of data at the present time comprises frozen pericardial fluid samples obtained from patients who have undergone cardiac surgery; and historical, clinical, and laboratory data obtained from the patient records. Nearly 400 samples have been stored and analyzed thus far, with sample entry continuing. This registry is designed to evaluate the local factors that play a role in mediating or reflecting myocardial or coronary responses. Pathophysiologic processes of particular interest include restenosis, plaque ruptures, and angiogenesis. Study of the pericardial fluid bank should lead to enhanced understanding of molecular mechanisms, as well as to the explanation for the reasons underlying interpatient variability in these processes. It is further anticipated that this information might provide a foundation for the diagnostic use of pericardial fluid to individualize therapies targeting angiogenesis or plaque physiology.

AB - The development of a clinically correlated human pericardial fluid bank and database is described. A unique feature of this registry is the availability of a large number of pericardial fluid samples for testing with respect to multiple factors and for correlation with angiographic findings and clinical syndromes expressed by the patients. The collection of data at the present time comprises frozen pericardial fluid samples obtained from patients who have undergone cardiac surgery; and historical, clinical, and laboratory data obtained from the patient records. Nearly 400 samples have been stored and analyzed thus far, with sample entry continuing. This registry is designed to evaluate the local factors that play a role in mediating or reflecting myocardial or coronary responses. Pathophysiologic processes of particular interest include restenosis, plaque ruptures, and angiogenesis. Study of the pericardial fluid bank should lead to enhanced understanding of molecular mechanisms, as well as to the explanation for the reasons underlying interpatient variability in these processes. It is further anticipated that this information might provide a foundation for the diagnostic use of pericardial fluid to individualize therapies targeting angiogenesis or plaque physiology.

KW - Angiogenesis

KW - Cytokines

KW - Database

KW - Growth factors

KW - Pericardial fluid

KW - Plaque stability

KW - Registry

UR - http://www.scopus.com/inward/record.url?scp=0032964541&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032964541&partnerID=8YFLogxK

M3 - Article

C2 - 9929767

AN - SCOPUS:0032964541

VL - 22

JO - Clinical Cardiology

JF - Clinical Cardiology

SN - 0160-9289

IS - 1 SUPPL.

ER -