Heidi D. Klepin, Kevin P. McMullen, Glenn J. Lesser

Research output: Contribution to journalReview article

17 Scopus citations


Esthesioneuroblastoma is a rare tumor for which the published literature does not provide an evidence-based consensus treatment approach. Multimodality therapy including a combination of surgery and radiation appears to provide the best disease-free and overall survival. Surgical resection should proceed through a craniofacial approach if possible. The role of chemotherapy in the initial treatment paradigm is less clear. Chemotherapy should not be used as single-modality therapy for initial treatment but may provide additional benefit when used in combination with radiation and surgery, particularly in advanced-stage disease. Combination chemotherapy should be considered as initial therapy for unresectable tumors and metastatic disease, and as salvage therapy in disease recurrence.

Original languageEnglish (US)
Pages (from-to)509-518
Number of pages10
JournalCurrent treatment options in oncology
Issue number6
StatePublished - Nov 1 2005

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)

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    Klepin, H. D., McMullen, K. P., & Lesser, G. J. (2005). Esthesioneuroblastoma. Current treatment options in oncology, 6(6), 509-518.