Heidi D. Klepin, Kevin P. McMullen, Glenn J. Lesser

Research output: Contribution to journalReview article

17 Scopus citations


Esthesioneuroblastoma is a rare tumor for which the published literature does not provide an evidence-based consensus treatment approach. Multimodality therapy including a combination of surgery and radiation appears to provide the best disease-free and overall survival. Surgical resection should proceed through a craniofacial approach if possible. The role of chemotherapy in the initial treatment paradigm is less clear. Chemotherapy should not be used as single-modality therapy for initial treatment but may provide additional benefit when used in combination with radiation and surgery, particularly in advanced-stage disease. Combination chemotherapy should be considered as initial therapy for unresectable tumors and metastatic disease, and as salvage therapy in disease recurrence.

Original languageEnglish (US)
Pages (from-to)509-518
Number of pages10
JournalCurrent treatment options in oncology
Issue number6
StatePublished - Nov 1 2005

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)

Cite this

Esthesioneuroblastoma. / Klepin, Heidi D.; McMullen, Kevin P.; Lesser, Glenn J.

In: Current treatment options in oncology, Vol. 6, No. 6, 01.11.2005, p. 509-518.

Research output: Contribution to journalReview article