Estimating sympathetic tone by recording subcutaneous nerve activity in ambulatory dogs

Eric A. Robinson, Kyoung Suk Rhee, Anisiia Doytchinova, Mohineesh Kumar, Richard Shelton, Zhaolei Jiang, Nicholas J. Kamp, David Adams, David Wagner, Changyu Shen, Lan Chen, Thomas Everett, Michael C. Fishbein, Shien-Fong Lin, Peng-Sheng Chen

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Subcutaneous Nerve Activity Introduction We tested the hypothesis that subcutaneous nerve activity (SCNA) of the thorax correlates with the stellate ganglion nerve activity (SGNA) and can be used to estimate the sympathetic tone. Methods and Results We implanted radio transmitters in 11 ambulatory dogs to record left SGNA, left thoracic vagal nerve activity (VNA), and left thoracic SCNA, including 3 with simultaneous video monitoring and nerve recording. Two additional dogs were studied under general anesthesia with apamin injected into the right stellate ganglion while the right SGNA and the right SCNA were recorded. There was a significant positive correlation between integrated SGNA (iSGNA) and integrated SCNA (iSCNA) in the first 7 ambulatory dogs, with correlation coefficient of 0.70 (95% confidence interval [CI] 0.61-0.84, P < 0.05 for each dog). Tachycardia episodes (heart rate exceeding 150 bpm for ≥3 seconds) were invariably preceded by SGNA and SCNA. There was circadian variation of both SCNA and SGNA. Crosstalk was ruled out because SGNA, VNA, and SCNA bursts had different timing and activation patterns. In an eighth dog, closely spaced bipolar subcutaneous electrodes also recorded SCNA, but with reduced signal to noise ratio. Video monitoring in additional 3 dogs showed that movement was not a cause of high frequency SCNA. The right SGNA correlated strongly with right SCNA and heart rate in 2 anesthetized dogs after apamin injection into the right stellate ganglion. Conclusions SCNA recorded by bipolar subcutaneous electrodes correlates with the SGNA and can be used to estimate the sympathetic tone.

Original languageEnglish
Pages (from-to)70-78
Number of pages9
JournalJournal of Cardiovascular Electrophysiology
Volume26
Issue number1
DOIs
StatePublished - Jan 1 2015

Fingerprint

Stellate Ganglion
Dogs
Thoracic Nerves
Apamin
Electrodes
Heart Rate
Signal-To-Noise Ratio
Radio
Tachycardia
General Anesthesia
Thorax

Keywords

  • autonomic ganglia
  • autonomic nervous system
  • cardiac arrhythmia
  • sympathetic tone
  • tachycardia
  • vagus

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Estimating sympathetic tone by recording subcutaneous nerve activity in ambulatory dogs. / Robinson, Eric A.; Rhee, Kyoung Suk; Doytchinova, Anisiia; Kumar, Mohineesh; Shelton, Richard; Jiang, Zhaolei; Kamp, Nicholas J.; Adams, David; Wagner, David; Shen, Changyu; Chen, Lan; Everett, Thomas; Fishbein, Michael C.; Lin, Shien-Fong; Chen, Peng-Sheng.

In: Journal of Cardiovascular Electrophysiology, Vol. 26, No. 1, 01.01.2015, p. 70-78.

Research output: Contribution to journalArticle

Robinson, EA, Rhee, KS, Doytchinova, A, Kumar, M, Shelton, R, Jiang, Z, Kamp, NJ, Adams, D, Wagner, D, Shen, C, Chen, L, Everett, T, Fishbein, MC, Lin, S-F & Chen, P-S 2015, 'Estimating sympathetic tone by recording subcutaneous nerve activity in ambulatory dogs', Journal of Cardiovascular Electrophysiology, vol. 26, no. 1, pp. 70-78. https://doi.org/10.1111/jce.12508
Robinson, Eric A. ; Rhee, Kyoung Suk ; Doytchinova, Anisiia ; Kumar, Mohineesh ; Shelton, Richard ; Jiang, Zhaolei ; Kamp, Nicholas J. ; Adams, David ; Wagner, David ; Shen, Changyu ; Chen, Lan ; Everett, Thomas ; Fishbein, Michael C. ; Lin, Shien-Fong ; Chen, Peng-Sheng. / Estimating sympathetic tone by recording subcutaneous nerve activity in ambulatory dogs. In: Journal of Cardiovascular Electrophysiology. 2015 ; Vol. 26, No. 1. pp. 70-78.
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abstract = "Subcutaneous Nerve Activity Introduction We tested the hypothesis that subcutaneous nerve activity (SCNA) of the thorax correlates with the stellate ganglion nerve activity (SGNA) and can be used to estimate the sympathetic tone. Methods and Results We implanted radio transmitters in 11 ambulatory dogs to record left SGNA, left thoracic vagal nerve activity (VNA), and left thoracic SCNA, including 3 with simultaneous video monitoring and nerve recording. Two additional dogs were studied under general anesthesia with apamin injected into the right stellate ganglion while the right SGNA and the right SCNA were recorded. There was a significant positive correlation between integrated SGNA (iSGNA) and integrated SCNA (iSCNA) in the first 7 ambulatory dogs, with correlation coefficient of 0.70 (95{\%} confidence interval [CI] 0.61-0.84, P < 0.05 for each dog). Tachycardia episodes (heart rate exceeding 150 bpm for ≥3 seconds) were invariably preceded by SGNA and SCNA. There was circadian variation of both SCNA and SGNA. Crosstalk was ruled out because SGNA, VNA, and SCNA bursts had different timing and activation patterns. In an eighth dog, closely spaced bipolar subcutaneous electrodes also recorded SCNA, but with reduced signal to noise ratio. Video monitoring in additional 3 dogs showed that movement was not a cause of high frequency SCNA. The right SGNA correlated strongly with right SCNA and heart rate in 2 anesthetized dogs after apamin injection into the right stellate ganglion. Conclusions SCNA recorded by bipolar subcutaneous electrodes correlates with the SGNA and can be used to estimate the sympathetic tone.",
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AU - Robinson, Eric A.

AU - Rhee, Kyoung Suk

AU - Doytchinova, Anisiia

AU - Kumar, Mohineesh

AU - Shelton, Richard

AU - Jiang, Zhaolei

AU - Kamp, Nicholas J.

AU - Adams, David

AU - Wagner, David

AU - Shen, Changyu

AU - Chen, Lan

AU - Everett, Thomas

AU - Fishbein, Michael C.

AU - Lin, Shien-Fong

AU - Chen, Peng-Sheng

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N2 - Subcutaneous Nerve Activity Introduction We tested the hypothesis that subcutaneous nerve activity (SCNA) of the thorax correlates with the stellate ganglion nerve activity (SGNA) and can be used to estimate the sympathetic tone. Methods and Results We implanted radio transmitters in 11 ambulatory dogs to record left SGNA, left thoracic vagal nerve activity (VNA), and left thoracic SCNA, including 3 with simultaneous video monitoring and nerve recording. Two additional dogs were studied under general anesthesia with apamin injected into the right stellate ganglion while the right SGNA and the right SCNA were recorded. There was a significant positive correlation between integrated SGNA (iSGNA) and integrated SCNA (iSCNA) in the first 7 ambulatory dogs, with correlation coefficient of 0.70 (95% confidence interval [CI] 0.61-0.84, P < 0.05 for each dog). Tachycardia episodes (heart rate exceeding 150 bpm for ≥3 seconds) were invariably preceded by SGNA and SCNA. There was circadian variation of both SCNA and SGNA. Crosstalk was ruled out because SGNA, VNA, and SCNA bursts had different timing and activation patterns. In an eighth dog, closely spaced bipolar subcutaneous electrodes also recorded SCNA, but with reduced signal to noise ratio. Video monitoring in additional 3 dogs showed that movement was not a cause of high frequency SCNA. The right SGNA correlated strongly with right SCNA and heart rate in 2 anesthetized dogs after apamin injection into the right stellate ganglion. Conclusions SCNA recorded by bipolar subcutaneous electrodes correlates with the SGNA and can be used to estimate the sympathetic tone.

AB - Subcutaneous Nerve Activity Introduction We tested the hypothesis that subcutaneous nerve activity (SCNA) of the thorax correlates with the stellate ganglion nerve activity (SGNA) and can be used to estimate the sympathetic tone. Methods and Results We implanted radio transmitters in 11 ambulatory dogs to record left SGNA, left thoracic vagal nerve activity (VNA), and left thoracic SCNA, including 3 with simultaneous video monitoring and nerve recording. Two additional dogs were studied under general anesthesia with apamin injected into the right stellate ganglion while the right SGNA and the right SCNA were recorded. There was a significant positive correlation between integrated SGNA (iSGNA) and integrated SCNA (iSCNA) in the first 7 ambulatory dogs, with correlation coefficient of 0.70 (95% confidence interval [CI] 0.61-0.84, P < 0.05 for each dog). Tachycardia episodes (heart rate exceeding 150 bpm for ≥3 seconds) were invariably preceded by SGNA and SCNA. There was circadian variation of both SCNA and SGNA. Crosstalk was ruled out because SGNA, VNA, and SCNA bursts had different timing and activation patterns. In an eighth dog, closely spaced bipolar subcutaneous electrodes also recorded SCNA, but with reduced signal to noise ratio. Video monitoring in additional 3 dogs showed that movement was not a cause of high frequency SCNA. The right SGNA correlated strongly with right SCNA and heart rate in 2 anesthetized dogs after apamin injection into the right stellate ganglion. Conclusions SCNA recorded by bipolar subcutaneous electrodes correlates with the SGNA and can be used to estimate the sympathetic tone.

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KW - cardiac arrhythmia

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KW - tachycardia

KW - vagus

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