Estimating the error rates of diagnostic tests.

S. L. Hui, S. D. Walter

Research output: Contribution to journalArticlepeer-review

484 Scopus citations


It is often required to evaluate the accuracy of a new diagnostic test against a standard test with unknown error rates. If the two tests are applied simultaneously to the same individuals from two populations with different disease prevalences, then assuming conditional independence of the errors of the two tests, the error rates of both tests and the true prevalences in both populations can be estimated by a maximum likelihood procedure. Generalizations to several tests applied in several populations are also possible.

Original languageEnglish (US)
Pages (from-to)167-171
Number of pages5
Issue number1
StatePublished - Mar 1980
Externally publishedYes

ASJC Scopus subject areas

  • Statistics and Probability
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

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