Estimation of ethanol infusion profile to produce specified BrAC time course using physiologically-based pharmacokinetic (PBPK) models

M. H. Plawecki, R. A. DeCarlo, V. A. Ramchandani, Sean O'Connor

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Scopus citations

Abstract

A procedure for estimating the alcohol infusion profile required to produce a specific breath alcohol concentration (BrAC) time course using a PBPK model is described. Model parameter values are predicted from linear relationships to readily measurable physical characteristics or morphometrics. An algorithm to optimize this transformation, based upon recorded clinical experimental data, is provided. A substantial improvement in all error statistics, in relation to the original transform was obtained.

Original languageEnglish
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Pages778-781
Number of pages4
Volume26 I
StatePublished - 2004
EventConference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004 - San Francisco, CA, United States
Duration: Sep 1 2004Sep 5 2004

Other

OtherConference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004
CountryUnited States
CitySan Francisco, CA
Period9/1/049/5/04

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Keywords

  • Alcohol
  • Breath alcohol concentration time course
  • Least squares approximation
  • Morphometrics
  • Optimization
  • Parameter identification
  • Pharmacokinetics
  • Physiologically-based pharmacokinetic model

ASJC Scopus subject areas

  • Bioengineering

Cite this

Plawecki, M. H., DeCarlo, R. A., Ramchandani, V. A., & O'Connor, S. (2004). Estimation of ethanol infusion profile to produce specified BrAC time course using physiologically-based pharmacokinetic (PBPK) models. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Vol. 26 I, pp. 778-781)