Estimation of fish and ω-3 fatty acid intake in pediatric nonalcoholic fatty liver disease

David E. St-Jules, Corilee A. Watters, Elizabeth M. Brunt, Lynne R. Wilkens, Rachel Novotny, Patricia Belt, Joel E. Lavine, Stephanie H. Abrams, Ryan Himes, Rajesh Krisnamurthy, Leanel Maldonado, Beverly Morris, Kimberlee Bernstein, Kim Cecil, Stephanie DeVore, Rohit Kohli, Kathleen Lake, Daniel Podberesky, Crystal Slaughter, Stavra XanthakosGerald Behr, Ali Mencin, Nadia Ovchinsky, Elena Reynoso, Adina Alazraki, Rebecca Cleeton, Saul Karpen, Nicholas Raviele, Miriam Vos, Elizabeth Byam, Oscar Cummings, Cynthia Fleming, Ann Klipsch, Jean Molleston, Kumar Sandrasegaran, Girish Subbarao, Kimberly Pfeifer, Ann Scheimann, Michael Torbenson, Jeanne M. Clark, Erin Corless, Michele Donithan, Milana Isaacson, Kevin P. May, Laura Miriel, Alice Sternberg, James Tonascia, Aynur Ünalp-Arida, Mark Van Natta, Ivana Vaughn, Laura Wilson, Katherine Yates, Ronen Arnon, Mariel Boyd, Katie Amsden, Mark H. Fishbein, Elizabeth Kirwan, Saeed Mohammad, Ann Quinn, Cynthia Rigsby, Peter F. Whitington, Sarah Barlow, Jose Derdoy, Ajay Jain, Debra King, Pat Osmack, Joan Siegner, Susan Stewart, Dana Romo, Sandra Arroyo, Cynthia Behling, Jennifer Collins, Janis Durelle, Michael Middleton, Kimberly Newton, Melissa Paiz, Jeffrey B. Schwimmer, Claude Sirlin, Patricia Ugalde-Nicalo, Bradley Aouizerat, Linda D. Ferrell, Shannon Fleck, Ryan Gill, Camille Langlois, Emily Rothbaum Perito, Philip Rosenthal, Patrika Tsai, Kara Cooper, Simon Horslen, Evelyn Hsu, Karen Murray, Randolph Otto, Deana Rich, Matthew Yeh, Melissa Young, Kathryn Fowler

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

AIMS:: Fish and ω-3 fatty acids are reported to be beneficial in pediatric nonalcoholic fatty liver disease (NAFLD), but no studies have assessed their relation to histological severity. The objectives of this study were to evaluate the dietary intake of fish and ω-3 fatty acids in children with biopsy-proven NAFLD, and examine their association with serological and histological indicators of disease. METHODS:: This was a cross-sectional analysis of 223 children (6-18 years) who participated in the Treatment of Nonalcoholic Fatty Liver Disease in Children trial or the NAFLD Database study conducted by the Nonalcoholic Steatohepatitis Clinical Research Network. The distribution of fish and ω-3 fatty acid intake was determined from responses to the Block Brief 2000 Food Frequency Questionnaire, and analyzed for associations with serum alanine aminotransferase, histological features of fatty liver disease, and diagnosis of steatohepatitis after adjusting for demographic, anthropometric, and dietary variables. RESULTS:: The minority of subjects consumed the recommended 8 ounces of fish per week (22/223 [10%]) and 200 mg of long-chain ω-3 fatty acids per day (12/223 [5%]). Lack of fish and long-chain ω-3 fatty acid intake was associated with greater portal (P=0.03 and P=0.10, respectively) and lobular inflammation (P=0.09 and P=0.004, respectively) after controlling for potential confounders. CONCLUSIONS:: Fish and ω-3 fatty acid intake was insufficient in children with NAFLD, which may increase susceptibility to hepatic inflammation. Patients with pediatric NAFLD should be encouraged to consume the recommended amount of fish per week.

Original languageEnglish
Pages (from-to)627-633
Number of pages7
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume57
Issue number5
DOIs
StatePublished - Nov 2013

Fingerprint

Fishes
Fatty Acids
Pediatrics
Fatty Liver
Inflammation
Non-alcoholic Fatty Liver Disease
Alanine Transaminase
Liver Diseases
Cross-Sectional Studies
Demography
Databases
Biopsy
Food
Liver
Serum
Research

Keywords

  • ω-3
  • adolescents
  • fatty acid
  • fish
  • nonalcoholic fatty liver disease

ASJC Scopus subject areas

  • Gastroenterology
  • Pediatrics, Perinatology, and Child Health

Cite this

St-Jules, D. E., Watters, C. A., Brunt, E. M., Wilkens, L. R., Novotny, R., Belt, P., ... Fowler, K. (2013). Estimation of fish and ω-3 fatty acid intake in pediatric nonalcoholic fatty liver disease. Journal of Pediatric Gastroenterology and Nutrition, 57(5), 627-633. https://doi.org/10.1097/MPG.0b013e3182a1df77

Estimation of fish and ω-3 fatty acid intake in pediatric nonalcoholic fatty liver disease. / St-Jules, David E.; Watters, Corilee A.; Brunt, Elizabeth M.; Wilkens, Lynne R.; Novotny, Rachel; Belt, Patricia; Lavine, Joel E.; Abrams, Stephanie H.; Himes, Ryan; Krisnamurthy, Rajesh; Maldonado, Leanel; Morris, Beverly; Bernstein, Kimberlee; Cecil, Kim; DeVore, Stephanie; Kohli, Rohit; Lake, Kathleen; Podberesky, Daniel; Slaughter, Crystal; Xanthakos, Stavra; Behr, Gerald; Mencin, Ali; Ovchinsky, Nadia; Reynoso, Elena; Alazraki, Adina; Cleeton, Rebecca; Karpen, Saul; Raviele, Nicholas; Vos, Miriam; Byam, Elizabeth; Cummings, Oscar; Fleming, Cynthia; Klipsch, Ann; Molleston, Jean; Sandrasegaran, Kumar; Subbarao, Girish; Pfeifer, Kimberly; Scheimann, Ann; Torbenson, Michael; Clark, Jeanne M.; Corless, Erin; Donithan, Michele; Isaacson, Milana; May, Kevin P.; Miriel, Laura; Sternberg, Alice; Tonascia, James; Ünalp-Arida, Aynur; Van Natta, Mark; Vaughn, Ivana; Wilson, Laura; Yates, Katherine; Arnon, Ronen; Boyd, Mariel; Amsden, Katie; Fishbein, Mark H.; Kirwan, Elizabeth; Mohammad, Saeed; Quinn, Ann; Rigsby, Cynthia; Whitington, Peter F.; Barlow, Sarah; Derdoy, Jose; Jain, Ajay; King, Debra; Osmack, Pat; Siegner, Joan; Stewart, Susan; Romo, Dana; Arroyo, Sandra; Behling, Cynthia; Collins, Jennifer; Durelle, Janis; Middleton, Michael; Newton, Kimberly; Paiz, Melissa; Schwimmer, Jeffrey B.; Sirlin, Claude; Ugalde-Nicalo, Patricia; Aouizerat, Bradley; Ferrell, Linda D.; Fleck, Shannon; Gill, Ryan; Langlois, Camille; Perito, Emily Rothbaum; Rosenthal, Philip; Tsai, Patrika; Cooper, Kara; Horslen, Simon; Hsu, Evelyn; Murray, Karen; Otto, Randolph; Rich, Deana; Yeh, Matthew; Young, Melissa; Fowler, Kathryn.

In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 57, No. 5, 11.2013, p. 627-633.

Research output: Contribution to journalArticle

St-Jules, DE, Watters, CA, Brunt, EM, Wilkens, LR, Novotny, R, Belt, P, Lavine, JE, Abrams, SH, Himes, R, Krisnamurthy, R, Maldonado, L, Morris, B, Bernstein, K, Cecil, K, DeVore, S, Kohli, R, Lake, K, Podberesky, D, Slaughter, C, Xanthakos, S, Behr, G, Mencin, A, Ovchinsky, N, Reynoso, E, Alazraki, A, Cleeton, R, Karpen, S, Raviele, N, Vos, M, Byam, E, Cummings, O, Fleming, C, Klipsch, A, Molleston, J, Sandrasegaran, K, Subbarao, G, Pfeifer, K, Scheimann, A, Torbenson, M, Clark, JM, Corless, E, Donithan, M, Isaacson, M, May, KP, Miriel, L, Sternberg, A, Tonascia, J, Ünalp-Arida, A, Van Natta, M, Vaughn, I, Wilson, L, Yates, K, Arnon, R, Boyd, M, Amsden, K, Fishbein, MH, Kirwan, E, Mohammad, S, Quinn, A, Rigsby, C, Whitington, PF, Barlow, S, Derdoy, J, Jain, A, King, D, Osmack, P, Siegner, J, Stewart, S, Romo, D, Arroyo, S, Behling, C, Collins, J, Durelle, J, Middleton, M, Newton, K, Paiz, M, Schwimmer, JB, Sirlin, C, Ugalde-Nicalo, P, Aouizerat, B, Ferrell, LD, Fleck, S, Gill, R, Langlois, C, Perito, ER, Rosenthal, P, Tsai, P, Cooper, K, Horslen, S, Hsu, E, Murray, K, Otto, R, Rich, D, Yeh, M, Young, M & Fowler, K 2013, 'Estimation of fish and ω-3 fatty acid intake in pediatric nonalcoholic fatty liver disease', Journal of Pediatric Gastroenterology and Nutrition, vol. 57, no. 5, pp. 627-633. https://doi.org/10.1097/MPG.0b013e3182a1df77
St-Jules, David E. ; Watters, Corilee A. ; Brunt, Elizabeth M. ; Wilkens, Lynne R. ; Novotny, Rachel ; Belt, Patricia ; Lavine, Joel E. ; Abrams, Stephanie H. ; Himes, Ryan ; Krisnamurthy, Rajesh ; Maldonado, Leanel ; Morris, Beverly ; Bernstein, Kimberlee ; Cecil, Kim ; DeVore, Stephanie ; Kohli, Rohit ; Lake, Kathleen ; Podberesky, Daniel ; Slaughter, Crystal ; Xanthakos, Stavra ; Behr, Gerald ; Mencin, Ali ; Ovchinsky, Nadia ; Reynoso, Elena ; Alazraki, Adina ; Cleeton, Rebecca ; Karpen, Saul ; Raviele, Nicholas ; Vos, Miriam ; Byam, Elizabeth ; Cummings, Oscar ; Fleming, Cynthia ; Klipsch, Ann ; Molleston, Jean ; Sandrasegaran, Kumar ; Subbarao, Girish ; Pfeifer, Kimberly ; Scheimann, Ann ; Torbenson, Michael ; Clark, Jeanne M. ; Corless, Erin ; Donithan, Michele ; Isaacson, Milana ; May, Kevin P. ; Miriel, Laura ; Sternberg, Alice ; Tonascia, James ; Ünalp-Arida, Aynur ; Van Natta, Mark ; Vaughn, Ivana ; Wilson, Laura ; Yates, Katherine ; Arnon, Ronen ; Boyd, Mariel ; Amsden, Katie ; Fishbein, Mark H. ; Kirwan, Elizabeth ; Mohammad, Saeed ; Quinn, Ann ; Rigsby, Cynthia ; Whitington, Peter F. ; Barlow, Sarah ; Derdoy, Jose ; Jain, Ajay ; King, Debra ; Osmack, Pat ; Siegner, Joan ; Stewart, Susan ; Romo, Dana ; Arroyo, Sandra ; Behling, Cynthia ; Collins, Jennifer ; Durelle, Janis ; Middleton, Michael ; Newton, Kimberly ; Paiz, Melissa ; Schwimmer, Jeffrey B. ; Sirlin, Claude ; Ugalde-Nicalo, Patricia ; Aouizerat, Bradley ; Ferrell, Linda D. ; Fleck, Shannon ; Gill, Ryan ; Langlois, Camille ; Perito, Emily Rothbaum ; Rosenthal, Philip ; Tsai, Patrika ; Cooper, Kara ; Horslen, Simon ; Hsu, Evelyn ; Murray, Karen ; Otto, Randolph ; Rich, Deana ; Yeh, Matthew ; Young, Melissa ; Fowler, Kathryn. / Estimation of fish and ω-3 fatty acid intake in pediatric nonalcoholic fatty liver disease. In: Journal of Pediatric Gastroenterology and Nutrition. 2013 ; Vol. 57, No. 5. pp. 627-633.
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abstract = "AIMS:: Fish and ω-3 fatty acids are reported to be beneficial in pediatric nonalcoholic fatty liver disease (NAFLD), but no studies have assessed their relation to histological severity. The objectives of this study were to evaluate the dietary intake of fish and ω-3 fatty acids in children with biopsy-proven NAFLD, and examine their association with serological and histological indicators of disease. METHODS:: This was a cross-sectional analysis of 223 children (6-18 years) who participated in the Treatment of Nonalcoholic Fatty Liver Disease in Children trial or the NAFLD Database study conducted by the Nonalcoholic Steatohepatitis Clinical Research Network. The distribution of fish and ω-3 fatty acid intake was determined from responses to the Block Brief 2000 Food Frequency Questionnaire, and analyzed for associations with serum alanine aminotransferase, histological features of fatty liver disease, and diagnosis of steatohepatitis after adjusting for demographic, anthropometric, and dietary variables. RESULTS:: The minority of subjects consumed the recommended 8 ounces of fish per week (22/223 [10{\%}]) and 200 mg of long-chain ω-3 fatty acids per day (12/223 [5{\%}]). Lack of fish and long-chain ω-3 fatty acid intake was associated with greater portal (P=0.03 and P=0.10, respectively) and lobular inflammation (P=0.09 and P=0.004, respectively) after controlling for potential confounders. CONCLUSIONS:: Fish and ω-3 fatty acid intake was insufficient in children with NAFLD, which may increase susceptibility to hepatic inflammation. Patients with pediatric NAFLD should be encouraged to consume the recommended amount of fish per week.",
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TY - JOUR

T1 - Estimation of fish and ω-3 fatty acid intake in pediatric nonalcoholic fatty liver disease

AU - St-Jules, David E.

AU - Watters, Corilee A.

AU - Brunt, Elizabeth M.

AU - Wilkens, Lynne R.

AU - Novotny, Rachel

AU - Belt, Patricia

AU - Lavine, Joel E.

AU - Abrams, Stephanie H.

AU - Himes, Ryan

AU - Krisnamurthy, Rajesh

AU - Maldonado, Leanel

AU - Morris, Beverly

AU - Bernstein, Kimberlee

AU - Cecil, Kim

AU - DeVore, Stephanie

AU - Kohli, Rohit

AU - Lake, Kathleen

AU - Podberesky, Daniel

AU - Slaughter, Crystal

AU - Xanthakos, Stavra

AU - Behr, Gerald

AU - Mencin, Ali

AU - Ovchinsky, Nadia

AU - Reynoso, Elena

AU - Alazraki, Adina

AU - Cleeton, Rebecca

AU - Karpen, Saul

AU - Raviele, Nicholas

AU - Vos, Miriam

AU - Byam, Elizabeth

AU - Cummings, Oscar

AU - Fleming, Cynthia

AU - Klipsch, Ann

AU - Molleston, Jean

AU - Sandrasegaran, Kumar

AU - Subbarao, Girish

AU - Pfeifer, Kimberly

AU - Scheimann, Ann

AU - Torbenson, Michael

AU - Clark, Jeanne M.

AU - Corless, Erin

AU - Donithan, Michele

AU - Isaacson, Milana

AU - May, Kevin P.

AU - Miriel, Laura

AU - Sternberg, Alice

AU - Tonascia, James

AU - Ünalp-Arida, Aynur

AU - Van Natta, Mark

AU - Vaughn, Ivana

AU - Wilson, Laura

AU - Yates, Katherine

AU - Arnon, Ronen

AU - Boyd, Mariel

AU - Amsden, Katie

AU - Fishbein, Mark H.

AU - Kirwan, Elizabeth

AU - Mohammad, Saeed

AU - Quinn, Ann

AU - Rigsby, Cynthia

AU - Whitington, Peter F.

AU - Barlow, Sarah

AU - Derdoy, Jose

AU - Jain, Ajay

AU - King, Debra

AU - Osmack, Pat

AU - Siegner, Joan

AU - Stewart, Susan

AU - Romo, Dana

AU - Arroyo, Sandra

AU - Behling, Cynthia

AU - Collins, Jennifer

AU - Durelle, Janis

AU - Middleton, Michael

AU - Newton, Kimberly

AU - Paiz, Melissa

AU - Schwimmer, Jeffrey B.

AU - Sirlin, Claude

AU - Ugalde-Nicalo, Patricia

AU - Aouizerat, Bradley

AU - Ferrell, Linda D.

AU - Fleck, Shannon

AU - Gill, Ryan

AU - Langlois, Camille

AU - Perito, Emily Rothbaum

AU - Rosenthal, Philip

AU - Tsai, Patrika

AU - Cooper, Kara

AU - Horslen, Simon

AU - Hsu, Evelyn

AU - Murray, Karen

AU - Otto, Randolph

AU - Rich, Deana

AU - Yeh, Matthew

AU - Young, Melissa

AU - Fowler, Kathryn

PY - 2013/11

Y1 - 2013/11

N2 - AIMS:: Fish and ω-3 fatty acids are reported to be beneficial in pediatric nonalcoholic fatty liver disease (NAFLD), but no studies have assessed their relation to histological severity. The objectives of this study were to evaluate the dietary intake of fish and ω-3 fatty acids in children with biopsy-proven NAFLD, and examine their association with serological and histological indicators of disease. METHODS:: This was a cross-sectional analysis of 223 children (6-18 years) who participated in the Treatment of Nonalcoholic Fatty Liver Disease in Children trial or the NAFLD Database study conducted by the Nonalcoholic Steatohepatitis Clinical Research Network. The distribution of fish and ω-3 fatty acid intake was determined from responses to the Block Brief 2000 Food Frequency Questionnaire, and analyzed for associations with serum alanine aminotransferase, histological features of fatty liver disease, and diagnosis of steatohepatitis after adjusting for demographic, anthropometric, and dietary variables. RESULTS:: The minority of subjects consumed the recommended 8 ounces of fish per week (22/223 [10%]) and 200 mg of long-chain ω-3 fatty acids per day (12/223 [5%]). Lack of fish and long-chain ω-3 fatty acid intake was associated with greater portal (P=0.03 and P=0.10, respectively) and lobular inflammation (P=0.09 and P=0.004, respectively) after controlling for potential confounders. CONCLUSIONS:: Fish and ω-3 fatty acid intake was insufficient in children with NAFLD, which may increase susceptibility to hepatic inflammation. Patients with pediatric NAFLD should be encouraged to consume the recommended amount of fish per week.

AB - AIMS:: Fish and ω-3 fatty acids are reported to be beneficial in pediatric nonalcoholic fatty liver disease (NAFLD), but no studies have assessed their relation to histological severity. The objectives of this study were to evaluate the dietary intake of fish and ω-3 fatty acids in children with biopsy-proven NAFLD, and examine their association with serological and histological indicators of disease. METHODS:: This was a cross-sectional analysis of 223 children (6-18 years) who participated in the Treatment of Nonalcoholic Fatty Liver Disease in Children trial or the NAFLD Database study conducted by the Nonalcoholic Steatohepatitis Clinical Research Network. The distribution of fish and ω-3 fatty acid intake was determined from responses to the Block Brief 2000 Food Frequency Questionnaire, and analyzed for associations with serum alanine aminotransferase, histological features of fatty liver disease, and diagnosis of steatohepatitis after adjusting for demographic, anthropometric, and dietary variables. RESULTS:: The minority of subjects consumed the recommended 8 ounces of fish per week (22/223 [10%]) and 200 mg of long-chain ω-3 fatty acids per day (12/223 [5%]). Lack of fish and long-chain ω-3 fatty acid intake was associated with greater portal (P=0.03 and P=0.10, respectively) and lobular inflammation (P=0.09 and P=0.004, respectively) after controlling for potential confounders. CONCLUSIONS:: Fish and ω-3 fatty acid intake was insufficient in children with NAFLD, which may increase susceptibility to hepatic inflammation. Patients with pediatric NAFLD should be encouraged to consume the recommended amount of fish per week.

KW - ω-3

KW - adolescents

KW - fatty acid

KW - fish

KW - nonalcoholic fatty liver disease

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JO - Journal of Pediatric Gastroenterology and Nutrition

JF - Journal of Pediatric Gastroenterology and Nutrition

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