Estimation of recent and long-term malaria transmission in a population by antibody testing to multiple Plasmodium falciparum antigens

Bartholomew N. Ondigo, James S. Hodges, Kathleen F. Ireland, Ng'wena G. Magak, David E. Lanar, Sheetij Dutta, David L. Narum, Gregory S. Park, Ayub V. Ofulla, Chandy John

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background: Tools that estimate recent and long-term malaria transmission in a population would be highly useful for malaria elimination programs. Methods: The prevalence of antibodies to 11 Plasmodium falciparum antigens was assessed by cytometric bead assay or enzyme-linked immunosorbent assay in 1000 people in a highland area of Kenya over 14 months, during a period of interrupted malaria transmission. Results: Antibodies differed by antigen in acquisition with age: rapid (>80% antibody positive by age 20 years, 5 antigens), moderate (>40% positive by age 20 years, 3 antigens), or slow (10 years of age were long (40 to >80 years) for 5 antigens, moderate (5-20 years) for 3 antigens, and short (

Original languageEnglish (US)
Pages (from-to)1123-1132
Number of pages10
JournalJournal of Infectious Diseases
Volume210
Issue number7
DOIs
StatePublished - 2014
Externally publishedYes

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Plasmodium falciparum
Malaria
Antigens
Antibodies
Population
Kenya
Enzyme-Linked Immunosorbent Assay

Keywords

  • Antibody
  • Elimination
  • Half-life
  • Malaria
  • Plasmodium falciparum

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy
  • Medicine(all)

Cite this

Estimation of recent and long-term malaria transmission in a population by antibody testing to multiple Plasmodium falciparum antigens. / Ondigo, Bartholomew N.; Hodges, James S.; Ireland, Kathleen F.; Magak, Ng'wena G.; Lanar, David E.; Dutta, Sheetij; Narum, David L.; Park, Gregory S.; Ofulla, Ayub V.; John, Chandy.

In: Journal of Infectious Diseases, Vol. 210, No. 7, 2014, p. 1123-1132.

Research output: Contribution to journalArticle

Ondigo, BN, Hodges, JS, Ireland, KF, Magak, NG, Lanar, DE, Dutta, S, Narum, DL, Park, GS, Ofulla, AV & John, C 2014, 'Estimation of recent and long-term malaria transmission in a population by antibody testing to multiple Plasmodium falciparum antigens', Journal of Infectious Diseases, vol. 210, no. 7, pp. 1123-1132. https://doi.org/10.1093/infdis/jiu225
Ondigo, Bartholomew N. ; Hodges, James S. ; Ireland, Kathleen F. ; Magak, Ng'wena G. ; Lanar, David E. ; Dutta, Sheetij ; Narum, David L. ; Park, Gregory S. ; Ofulla, Ayub V. ; John, Chandy. / Estimation of recent and long-term malaria transmission in a population by antibody testing to multiple Plasmodium falciparum antigens. In: Journal of Infectious Diseases. 2014 ; Vol. 210, No. 7. pp. 1123-1132.
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AU - Lanar, David E.

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