Estimation of recent and long-term malaria transmission in a population by antibody testing to multiple Plasmodium falciparum antigens

Bartholomew N. Ondigo, James S. Hodges, Kathleen F. Ireland, Ng'wena G. Magak, David E. Lanar, Sheetij Dutta, David L. Narum, Gregory S. Park, Ayub V. Ofulla, Chandy C. John

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Background: Tools that estimate recent and long-term malaria transmission in a population would be highly useful for malaria elimination programs. Methods: The prevalence of antibodies to 11 Plasmodium falciparum antigens was assessed by cytometric bead assay or enzyme-linked immunosorbent assay in 1000 people in a highland area of Kenya over 14 months, during a period of interrupted malaria transmission. Results: Antibodies differed by antigen in acquisition with age: rapid (>80% antibody positive by age 20 years, 5 antigens), moderate (>40% positive by age 20 years, 3 antigens), or slow (<40% positive by age 20 years, 3 antigens). Antibody seroreversion rates in the 14 months between samples decreased with age rapidly (7 antigens), slowly (3 antigens), or remained high at all ages (schizont extract). Estimated antibody half-lives in individuals >10 years of age were long (40 to >80 years) for 5 antigens, moderate (5-20 years) for 3 antigens, and short (<1 year) for 3 antigens. Conclusions: Antibodies to P. falciparum antigens in malaria-endemic areas vary by age, antigen, and time since last exposure to P. falciparum. Multiplex P. falciparum antibody testing could provide estimates of long-term and recent malaria transmission and potentially of a population's susceptibility to future clinical malaria.

Original languageEnglish (US)
Pages (from-to)1123-1132
Number of pages10
JournalJournal of Infectious Diseases
Volume210
Issue number7
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Keywords

  • Antibody
  • Elimination
  • Half-life
  • Malaria
  • Plasmodium falciparum

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Ondigo, B. N., Hodges, J. S., Ireland, K. F., Magak, N. G., Lanar, D. E., Dutta, S., Narum, D. L., Park, G. S., Ofulla, A. V., & John, C. C. (2014). Estimation of recent and long-term malaria transmission in a population by antibody testing to multiple Plasmodium falciparum antigens. Journal of Infectious Diseases, 210(7), 1123-1132. https://doi.org/10.1093/infdis/jiu225