Estrogen protects against radiation-induced cataractogenesis

Joseph Dynlacht, Shailaja Valluri, Jennifer Lopez, Falon Greer, Colleen DesRosiers, Andrea Caperell-Grant, Marc Mendonca, Robert Bigsby

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Cataractogenesis is a complication of radiotherapy when the eye is included in the treatment field. Low doses of densely ionizing space radiation may also result in an increased risk of cataracts in astronauts. We previously reported that estrogen (17-β-estradiol), when administered to ovariectomized rats commencing 1 week before γ irradiation of the eye and continuously thereafter, results in a significant increase in the rate and incidence of cataract formation and a decreased latent period compared to an ovariectomized control group. We therefore concluded that estrogen accelerates progression of radiation-induced opacification. We now show that estrogen, if administered continuously, but commencing after irradiation, protects against radiation cataractogenesis. Both the rate of progression and incidence of cataracts were greatly reduced in ovariectomized rats that received estrogen treatment after irradiation compared to ovariectomized rats. As in our previous study, estradiol administered 1 week prior to irradiation at the time of ovariectomy and throughout the period of observation produced an enhanced rate of cataract progression. Estrogen administered for only 1 week prior to irradiation had no effect on the rate of progression but resulted in a slight reduction in the incidence. We conclude that estrogen may enhance or protect against radiation cataractogenesis, depending on when it is administered relative to the time of irradiation, and may differentially modulate the initiation and progression phases of cataractogenesis. These data have important implications for astronauts and radiotherapy patients.

Original languageEnglish
Pages (from-to)758-764
Number of pages7
JournalRadiation Research
Volume170
Issue number6
DOIs
StatePublished - Dec 2008

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estrogens
cataracts
Estrogens
progressions
Radiation
Cataract
irradiation
radiation
Astronauts
rats
astronauts
incidence
radiation therapy
Estradiol
Incidence
Radiotherapy
extraterrestrial radiation
Ovariectomy
Ionizing Radiation
Observation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Biophysics
  • Radiation

Cite this

Estrogen protects against radiation-induced cataractogenesis. / Dynlacht, Joseph; Valluri, Shailaja; Lopez, Jennifer; Greer, Falon; DesRosiers, Colleen; Caperell-Grant, Andrea; Mendonca, Marc; Bigsby, Robert.

In: Radiation Research, Vol. 170, No. 6, 12.2008, p. 758-764.

Research output: Contribution to journalArticle

Dynlacht, Joseph ; Valluri, Shailaja ; Lopez, Jennifer ; Greer, Falon ; DesRosiers, Colleen ; Caperell-Grant, Andrea ; Mendonca, Marc ; Bigsby, Robert. / Estrogen protects against radiation-induced cataractogenesis. In: Radiation Research. 2008 ; Vol. 170, No. 6. pp. 758-764.
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