Estrogen-replacement therapy: Effects on retrobulbar hemodynamics

Mira Harris-Yitzhak, Alon Harris, Zion Ben-Refael, Drora Zarfati, Hanna J. Garzozi, Bruce J. Martin

Research output: Contribution to journalArticle

63 Scopus citations


PURPOSE: Estrogen-replacement therapy causes vasodilation and increased blood flow in major peripheral arteries. We examined the role that estrogen may play in enhancing perfusion within the watersheds of several major and minor retrobulbar arteries. METHODS: Postmenopausal women receiving estrogen-replacement therapy (n = 16) were compared with both age-matched women not receiving estrogen (n = 16) and with young women (n = 20). Studies involved color Doppler imaging analysis of flow velocities measured in the ophthalmic, central retinal, and nasal and temporal posterior ciliary arteries. RESULTS: In the ophthalmic artery, young women and postmenopausal women receiving estrogen exhibited reduced resistance indexes as compared with postmenopausal women not receiving estrogen (each P < .001). In contrast, flow velocities in the central retinal artery were similar among the three groups of women. In the posterior ciliary arteries, a different pattern emerged: young women, as compared with either group of postmenopausal women, showed greater peak systolic and end-diastolic velocities at similar resistance index (each P < .05). CONCLUSIONS: Estrogen-replacement therapy in postmenopausal women apparently helps reduce vascular resistance distal to the ophthalmic artery to levels matching those of young women. However, estrogen replacement has little impact on flow velocities in the posterior ciliary arteries. In those vessels, aging per se may reduce perfusion, potentially contributing to the age-dependent risk of major eye diseases, such as glaucoma and age-related macular degeneration. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)623-628
Number of pages6
JournalAmerican Journal of Ophthalmology
Issue number5
StatePublished - May 1 2000
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology

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    Harris-Yitzhak, M., Harris, A., Ben-Refael, Z., Zarfati, D., Garzozi, H. J., & Martin, B. J. (2000). Estrogen-replacement therapy: Effects on retrobulbar hemodynamics. American Journal of Ophthalmology, 129(5), 623-628.