ET - Phone the pain clinic

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Recent findings by Khodorova et al. demonstrate that the vasoconstrictor endothelin-1 plays an important role in certain nociceptive behaviors in an animal model of pain, through activation of sensory neurons. Endothelin-1 might also have the unexpected capacity to release an opioid from surrounding keratinocytes and thereby inhibit the pain response. Such results suggest that, in the periphery, there are important interactions between sensory nerve terminals and surrounding cells, and that glia and keratinocytes could modulate the perception of environmental stimuli to a greater extent than previously considered.

Original languageEnglish
Pages (from-to)177-180
Number of pages4
JournalTrends in Neurosciences
Volume27
Issue number4
DOIs
StatePublished - Apr 2004

Fingerprint

Pain Clinics
Endothelin-1
Keratinocytes
Pain
Vasoconstrictor Agents
Sensory Receptor Cells
Neuroglia
Opioid Analgesics
Animal Models

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

ET - Phone the pain clinic. / Nicol, Grant.

In: Trends in Neurosciences, Vol. 27, No. 4, 04.2004, p. 177-180.

Research output: Contribution to journalArticle

Nicol, Grant. / ET - Phone the pain clinic. In: Trends in Neurosciences. 2004 ; Vol. 27, No. 4. pp. 177-180.
@article{2fe700315b6e47c3acf54e1574efa3cd,
title = "ET - Phone the pain clinic",
abstract = "Recent findings by Khodorova et al. demonstrate that the vasoconstrictor endothelin-1 plays an important role in certain nociceptive behaviors in an animal model of pain, through activation of sensory neurons. Endothelin-1 might also have the unexpected capacity to release an opioid from surrounding keratinocytes and thereby inhibit the pain response. Such results suggest that, in the periphery, there are important interactions between sensory nerve terminals and surrounding cells, and that glia and keratinocytes could modulate the perception of environmental stimuli to a greater extent than previously considered.",
author = "Grant Nicol",
year = "2004",
month = "4",
doi = "10.1016/j.tins.2004.02.001",
language = "English",
volume = "27",
pages = "177--180",
journal = "Trends in Neurosciences",
issn = "0378-5912",
publisher = "Elsevier Limited",
number = "4",

}

TY - JOUR

T1 - ET - Phone the pain clinic

AU - Nicol, Grant

PY - 2004/4

Y1 - 2004/4

N2 - Recent findings by Khodorova et al. demonstrate that the vasoconstrictor endothelin-1 plays an important role in certain nociceptive behaviors in an animal model of pain, through activation of sensory neurons. Endothelin-1 might also have the unexpected capacity to release an opioid from surrounding keratinocytes and thereby inhibit the pain response. Such results suggest that, in the periphery, there are important interactions between sensory nerve terminals and surrounding cells, and that glia and keratinocytes could modulate the perception of environmental stimuli to a greater extent than previously considered.

AB - Recent findings by Khodorova et al. demonstrate that the vasoconstrictor endothelin-1 plays an important role in certain nociceptive behaviors in an animal model of pain, through activation of sensory neurons. Endothelin-1 might also have the unexpected capacity to release an opioid from surrounding keratinocytes and thereby inhibit the pain response. Such results suggest that, in the periphery, there are important interactions between sensory nerve terminals and surrounding cells, and that glia and keratinocytes could modulate the perception of environmental stimuli to a greater extent than previously considered.

UR - http://www.scopus.com/inward/record.url?scp=1642269712&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1642269712&partnerID=8YFLogxK

U2 - 10.1016/j.tins.2004.02.001

DO - 10.1016/j.tins.2004.02.001

M3 - Article

VL - 27

SP - 177

EP - 180

JO - Trends in Neurosciences

JF - Trends in Neurosciences

SN - 0378-5912

IS - 4

ER -