Ethanol dependence and the pituitary-adrenal axis in mice I. Genotypic differences in hormone levels.

John C. Crabbe, L. Donald Keith, Ann Kosobud, Julianne Stack

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Resting pituitary levels of β-endorphin-(β-EP-IR), ACTH-(ACTH-IR), and α-MSH-(α-MSH-IR)-like immunoreactive material were found to differ among 16 inbred mouse strains. Hormone levels correlated genetically with severity of withdrawal from ethanol, which also differed among the strains. Ethanol dependence led to reduced pituitary β-EP-IR in 4 of 5 strains studied. After 24 hr of withdrawal, 3 of those 4 showed elevated pituitary β-EP-IR. These results are consistent with the hypothesis that genetically-determined difference in pituitary hormone functioning underlie some of the genetically-determined differences in ethanol withdrawal severity.

Original languageEnglish (US)
Pages (from-to)1877-1887
Number of pages11
JournalLife Sciences
Volume33
Issue number19
DOIs
StatePublished - Nov 7 1983
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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