Ethanol sensitization in a neurodevelopmental lesion model of Schizophrenia in rats

Susan K. Conroy, Zachary Rodd, R. Chambers

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Substance use disorder comorbidity in schizophrenia may reflect dysfunctional cortical-striatal-limbic circuitry commonly involved in the addiction process and the pathogenesis of schizophrenia. Rats with neonatal ventral hippocampal lesions (NVHL) demonstrate post-adolescent onset of schizophrenia-like symptoms and increased addiction vulnerability in paradigms using cocaine in adulthood. Here, we investigated response profiles of young adult NVHL vs. SHAM rats to ethanol, an addictive drug with many psychopharmacological effects divergent from those of cocaine, in a locomotor sensitization paradigm. Over 15 days of daily injections of saline, low (0.15 g/kg) or high (1.0 g/kg) doses of ethanol, NVHL rats showed stimulatory effects at the low dose compared to saline and high-dose conditions, while SHAM rats showed expected patterns of dose-dependent suppression of locomotor activity. In a challenge session 2 weeks later in which a moderate dose (0.25 g/kg) of ethanol was given to all subjects, NVHL rats with history of prior ethanol exposure showed greater locomotor activity consistent with installment of alcohol-induced sensitization not present in SHAMs. These findings provide further evidence of enhanced short- and long-term responsivity to abused drugs in a neurodevelopmental model of schizophrenia, and may reflect potentiation of common mechanisms of addiction shared between pharmacologically diverse addictive drugs.

Original languageEnglish
Pages (from-to)386-394
Number of pages9
JournalPharmacology Biochemistry and Behavior
Volume86
Issue number2
DOIs
StatePublished - Feb 2007

Fingerprint

Rats
Schizophrenia
Ethanol
Locomotion
Cocaine
Pharmaceutical Preparations
Corpus Striatum
Substance-Related Disorders
Comorbidity
Young Adult
Alcohols
Injections
salicylhydroxamic acid

Keywords

  • Addiction
  • Alcohol
  • Dopamine
  • Dual diagnosis
  • Neonatal ventral hippocampal lesions
  • Schizophrenia
  • Sensitization

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Ethanol sensitization in a neurodevelopmental lesion model of Schizophrenia in rats. / Conroy, Susan K.; Rodd, Zachary; Chambers, R.

In: Pharmacology Biochemistry and Behavior, Vol. 86, No. 2, 02.2007, p. 386-394.

Research output: Contribution to journalArticle

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