Etiology of gonadotropin-dependent precocious puberty

Erik A. Imel, Kathleen E. Bethin

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Precocious puberty is puberty occurring earlier than 2.5 SD below the mean. In boys, this is before age 9. In girls, the age is controversial, but classically, has been considered age 8 for white girls and 7 for African American girls. Precocious Puberty can be centrally or peripherally mediated and is more common in girls than boys. In central precocious puberty (CPP) the concern is to identify whether the etiology is pathological or idiopathic. In girls, the cause of CPP is usually idiopathic but in boys a central lesion is more common. The most commonly identified cause of CPP is the hypothalamic hamartoma. A head MRI should be considered in any child with CPP to rule out occult intracranial lesions.

Original languageEnglish (US)
Title of host publicationClinical Handbook of Insomnia
EditorsHrayr Attarian
Number of pages14
StatePublished - Dec 1 2010
Externally publishedYes

Publication series

NameCurrent Clinical Neurology
ISSN (Print)1559-0585


  • Central precocious puberty
  • Etiology
  • GnRH
  • Gonadotropin -dependent
  • Idiopathic
  • Intracranial

ASJC Scopus subject areas

  • Clinical Neurology

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  • Cite this

    Imel, E. A., & Bethin, K. E. (2010). Etiology of gonadotropin-dependent precocious puberty. In H. Attarian (Ed.), Clinical Handbook of Insomnia (pp. 331-344). (Current Clinical Neurology).