Etoposide, Ifosfamide, and Cisplatin in Extensive Small Cell Lung Cancer

Patrick J. Loehrer, Susan Rynard, Rafat Ansari, Joseph Songer, Kenneth Pennington, Lawrence Einhorn

Research output: Contribution to journalArticle

31 Scopus citations


From December 1987 through April 1989, 40 patients with extensive-stage small cell carcinoma of the lung were enrolled in a Hoosier Oncology Group (HOG) trial using etoposide, ifosfamide, and cisplatin (VIP). Patients with extensive disease were eligible if they had not received prior chemotherapy, had a Karnofsky performance status of 50 or more, and had adequate renal function (creatinine, < 1.5 mg/dl) and bone marrow reserve (granulocyte count, ≥ 2500/μl; platelets, ≥ 125,000/μl). Doses of therapy were: etoposide 75 mg/m2/day on days 1 to 5, ifosfamide 1.2 g/m2/day on days 1 to 5, and cisplatin 20 mg/m2/day on days 1 to 5. The first 11 patients received a 5-day course; this was repeated every 21 days for four cycles, but therapy was shortened to 4 days when unacceptable toxicity was noticed in these patients. Overall, 14 (37%) had a complete remission (overall response rate, 71.1%) with a median survival of 42 weeks (28 weeks on 5-day regimen and 45 weeks on 4-day regimen). There were five early deaths. Although toxic, VIP produces a high complete remission rate in patients with extensive disease and warrants further evaluation. A prospective randomized trial comparing cisplatin and etoposide to the VIP regimen is underway through HOG.

Original languageEnglish (US)
Pages (from-to)669-673
Number of pages5
Issue number3
StatePublished - Feb 1 1992

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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