EUS and clinical characteristics of cystic pancreatic neuroendocrine tumors

P. Kongkam, M. Al-Haddad, S. Attasaranya, J. O'Neil, S. Pais, Stuart Sherman, John DeWitt

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Abstract

Pancreatic neuroendocrine tumors (PNETs) may rarely appear as cystic or mixed solid-cystic masses. The endoscopic ultrasound (EUS) morphology and cyst fluid characteristics of these tumors are not well clarified. We retrospectively identified nine adult patients with nine single cystic pancreatic neuroendocrine tumors (CNETs). These nine included 0.67% of the 1344 patients with pancreatic cystic lesions and 9.5% of the 95 confirmed PNETs evaluated over the 12-year study period. At presentation, four patients were asymptomatic and five had known acute pancreatitis (n = 2), MEN-1 syndrome with hypoglycemia (n = 1), and abdominal pain (n = 2). Median maximal tumor diameter was 26 mm (range 20-64 mm). EUS morphology was mixed solid and cystic (n = 4) or cystic alone (n = 5). Cytology from EUS-fine-needle aspiration (FNA) (median 2 passes; range 1-6) demonstrated a PNET, and immunocytochemistry was confirmatory in all patients. Cyst fluid carcinoembryonic antigen (CEA) (n = 4) and amylase (n = 5) ranged from 0.1 to 1.8 ng/ml (normal 0-2.5 ng/ml) and 72 to 1838 U/L (normal 25-161 U/L), respectively. Six patients underwent surgery, and the preoperative diagnosis was confirmed in all.

Original languageEnglish
Pages (from-to)602-605
Number of pages4
JournalEndoscopy
Volume40
Issue number7
DOIs
StatePublished - Jul 2008

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Neuroendocrine Tumors
Cyst Fluid
Multiple Endocrine Neoplasia Type 1
Carcinoembryonic Antigen
Amylases
Fine Needle Biopsy
Hypoglycemia
Pancreatitis
Abdominal Pain
Cell Biology
Neoplasms
Immunohistochemistry

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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EUS and clinical characteristics of cystic pancreatic neuroendocrine tumors. / Kongkam, P.; Al-Haddad, M.; Attasaranya, S.; O'Neil, J.; Pais, S.; Sherman, Stuart; DeWitt, John.

In: Endoscopy, Vol. 40, No. 7, 07.2008, p. 602-605.

Research output: Contribution to journalArticle

Kongkam, P, Al-Haddad, M, Attasaranya, S, O'Neil, J, Pais, S, Sherman, S & DeWitt, J 2008, 'EUS and clinical characteristics of cystic pancreatic neuroendocrine tumors', Endoscopy, vol. 40, no. 7, pp. 602-605. https://doi.org/10.1055/s-2007-995740
Kongkam P, Al-Haddad M, Attasaranya S, O'Neil J, Pais S, Sherman S et al. EUS and clinical characteristics of cystic pancreatic neuroendocrine tumors. Endoscopy. 2008 Jul;40(7):602-605. https://doi.org/10.1055/s-2007-995740
Kongkam, P. ; Al-Haddad, M. ; Attasaranya, S. ; O'Neil, J. ; Pais, S. ; Sherman, Stuart ; DeWitt, John. / EUS and clinical characteristics of cystic pancreatic neuroendocrine tumors. In: Endoscopy. 2008 ; Vol. 40, No. 7. pp. 602-605.
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