EUS-guided FNA aspiration of kidney masses: a multicenter U.S. experience

John DeWitt, Frank G. Gress, Michael J. Levy, Lyndon V. Hernandez, Mohamad A. Eloubeidi, Girish Mishra, Stuart Sherman, Mohammad A. Al-Haddad, Julia K. LeBlanc

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Abstract

Background: Tissue sampling of renal lesions is traditionally performed with percutaneous US or CT guidance. To date, only 3 known cases of EUS-guided FNA (EUS-FNA) of a renal mass have been reported. Objective: To describe a multicenter experience with the indications, yield, and complications from attempted EUS-FNA of a kidney mass. Design: Retrospective case series. Setting: Six tertiary referral hospitals in the United States. Patients: Consecutive subjects undergoing attempted EUS-FNA of a kidney mass. Endosonographers at 15 other teaching hospitals were contacted regarding EUS findings and follow-up of any EUS-guided renal biopsies previously attempted or considered at that institution. Interventions: EUS-FNA of a kidney mass. Main Outcome Measurements: Biopsy indications, yield, diagnosis, and complications. Results: Fifteen procedures in 15 patients (9 men; median age 67 years) were performed at 6 (37%) of 16 hospitals (Indiana University plus 15 other hospitals). Kidney masses (median diameter 32 mm; range 11-60 mm) were located in the upper (n = 12) and lower (n = 3) poles of the left (n = 10) and right (n = 5) kidneys, respectively. Initial mass detection was by previous imaging in 13 (87%) patients or by EUS in 2 (13%) patients. Results of EUS-FNA (median 3 passes; range 2-4 passes) in 13 (87%) procedures were diagnostic of (n = 7) or highly suspicious for (n = 1) renal cell carcinoma (RCC), atypical cells (n = 2), oncocytoma (n = 1), benign cyst (n = 1), and nondiagnostic (n = 1). No complications were encountered. Surgical resection confirmed RCC in 7 patients in whom preoperative EUS-FNA demonstrated RCC (n = 5) or oncocytoma (n = 1) or was not performed (n = 1). Limitations: Retrospective series, small number of patients. Conclusions: EUS-FNA of renal masses is rarely performed at the U.S. teaching hospitals surveyed. This technique appears safe and feasible and should be considered when results would affect patient management.

Original languageEnglish
Pages (from-to)573-578
Number of pages6
JournalGastrointestinal Endoscopy
Volume70
Issue number3
DOIs
StatePublished - Sep 2009

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Endoscopic Ultrasound-Guided Fine Needle Aspiration
Kidney
Oxyphilic Adenoma
Renal Cell Carcinoma
Teaching Hospitals
Biopsy
Tertiary Care Centers
Cysts

ASJC Scopus subject areas

  • Gastroenterology
  • Radiology Nuclear Medicine and imaging

Cite this

DeWitt, J., Gress, F. G., Levy, M. J., Hernandez, L. V., Eloubeidi, M. A., Mishra, G., ... LeBlanc, J. K. (2009). EUS-guided FNA aspiration of kidney masses: a multicenter U.S. experience. Gastrointestinal Endoscopy, 70(3), 573-578. https://doi.org/10.1016/j.gie.2009.04.006

EUS-guided FNA aspiration of kidney masses : a multicenter U.S. experience. / DeWitt, John; Gress, Frank G.; Levy, Michael J.; Hernandez, Lyndon V.; Eloubeidi, Mohamad A.; Mishra, Girish; Sherman, Stuart; Al-Haddad, Mohammad A.; LeBlanc, Julia K.

In: Gastrointestinal Endoscopy, Vol. 70, No. 3, 09.2009, p. 573-578.

Research output: Contribution to journalArticle

DeWitt, J, Gress, FG, Levy, MJ, Hernandez, LV, Eloubeidi, MA, Mishra, G, Sherman, S, Al-Haddad, MA & LeBlanc, JK 2009, 'EUS-guided FNA aspiration of kidney masses: a multicenter U.S. experience', Gastrointestinal Endoscopy, vol. 70, no. 3, pp. 573-578. https://doi.org/10.1016/j.gie.2009.04.006
DeWitt, John ; Gress, Frank G. ; Levy, Michael J. ; Hernandez, Lyndon V. ; Eloubeidi, Mohamad A. ; Mishra, Girish ; Sherman, Stuart ; Al-Haddad, Mohammad A. ; LeBlanc, Julia K. / EUS-guided FNA aspiration of kidney masses : a multicenter U.S. experience. In: Gastrointestinal Endoscopy. 2009 ; Vol. 70, No. 3. pp. 573-578.
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abstract = "Background: Tissue sampling of renal lesions is traditionally performed with percutaneous US or CT guidance. To date, only 3 known cases of EUS-guided FNA (EUS-FNA) of a renal mass have been reported. Objective: To describe a multicenter experience with the indications, yield, and complications from attempted EUS-FNA of a kidney mass. Design: Retrospective case series. Setting: Six tertiary referral hospitals in the United States. Patients: Consecutive subjects undergoing attempted EUS-FNA of a kidney mass. Endosonographers at 15 other teaching hospitals were contacted regarding EUS findings and follow-up of any EUS-guided renal biopsies previously attempted or considered at that institution. Interventions: EUS-FNA of a kidney mass. Main Outcome Measurements: Biopsy indications, yield, diagnosis, and complications. Results: Fifteen procedures in 15 patients (9 men; median age 67 years) were performed at 6 (37{\%}) of 16 hospitals (Indiana University plus 15 other hospitals). Kidney masses (median diameter 32 mm; range 11-60 mm) were located in the upper (n = 12) and lower (n = 3) poles of the left (n = 10) and right (n = 5) kidneys, respectively. Initial mass detection was by previous imaging in 13 (87{\%}) patients or by EUS in 2 (13{\%}) patients. Results of EUS-FNA (median 3 passes; range 2-4 passes) in 13 (87{\%}) procedures were diagnostic of (n = 7) or highly suspicious for (n = 1) renal cell carcinoma (RCC), atypical cells (n = 2), oncocytoma (n = 1), benign cyst (n = 1), and nondiagnostic (n = 1). No complications were encountered. Surgical resection confirmed RCC in 7 patients in whom preoperative EUS-FNA demonstrated RCC (n = 5) or oncocytoma (n = 1) or was not performed (n = 1). Limitations: Retrospective series, small number of patients. Conclusions: EUS-FNA of renal masses is rarely performed at the U.S. teaching hospitals surveyed. This technique appears safe and feasible and should be considered when results would affect patient management.",
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T2 - a multicenter U.S. experience

AU - DeWitt, John

AU - Gress, Frank G.

AU - Levy, Michael J.

AU - Hernandez, Lyndon V.

AU - Eloubeidi, Mohamad A.

AU - Mishra, Girish

AU - Sherman, Stuart

AU - Al-Haddad, Mohammad A.

AU - LeBlanc, Julia K.

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N2 - Background: Tissue sampling of renal lesions is traditionally performed with percutaneous US or CT guidance. To date, only 3 known cases of EUS-guided FNA (EUS-FNA) of a renal mass have been reported. Objective: To describe a multicenter experience with the indications, yield, and complications from attempted EUS-FNA of a kidney mass. Design: Retrospective case series. Setting: Six tertiary referral hospitals in the United States. Patients: Consecutive subjects undergoing attempted EUS-FNA of a kidney mass. Endosonographers at 15 other teaching hospitals were contacted regarding EUS findings and follow-up of any EUS-guided renal biopsies previously attempted or considered at that institution. Interventions: EUS-FNA of a kidney mass. Main Outcome Measurements: Biopsy indications, yield, diagnosis, and complications. Results: Fifteen procedures in 15 patients (9 men; median age 67 years) were performed at 6 (37%) of 16 hospitals (Indiana University plus 15 other hospitals). Kidney masses (median diameter 32 mm; range 11-60 mm) were located in the upper (n = 12) and lower (n = 3) poles of the left (n = 10) and right (n = 5) kidneys, respectively. Initial mass detection was by previous imaging in 13 (87%) patients or by EUS in 2 (13%) patients. Results of EUS-FNA (median 3 passes; range 2-4 passes) in 13 (87%) procedures were diagnostic of (n = 7) or highly suspicious for (n = 1) renal cell carcinoma (RCC), atypical cells (n = 2), oncocytoma (n = 1), benign cyst (n = 1), and nondiagnostic (n = 1). No complications were encountered. Surgical resection confirmed RCC in 7 patients in whom preoperative EUS-FNA demonstrated RCC (n = 5) or oncocytoma (n = 1) or was not performed (n = 1). Limitations: Retrospective series, small number of patients. Conclusions: EUS-FNA of renal masses is rarely performed at the U.S. teaching hospitals surveyed. This technique appears safe and feasible and should be considered when results would affect patient management.

AB - Background: Tissue sampling of renal lesions is traditionally performed with percutaneous US or CT guidance. To date, only 3 known cases of EUS-guided FNA (EUS-FNA) of a renal mass have been reported. Objective: To describe a multicenter experience with the indications, yield, and complications from attempted EUS-FNA of a kidney mass. Design: Retrospective case series. Setting: Six tertiary referral hospitals in the United States. Patients: Consecutive subjects undergoing attempted EUS-FNA of a kidney mass. Endosonographers at 15 other teaching hospitals were contacted regarding EUS findings and follow-up of any EUS-guided renal biopsies previously attempted or considered at that institution. Interventions: EUS-FNA of a kidney mass. Main Outcome Measurements: Biopsy indications, yield, diagnosis, and complications. Results: Fifteen procedures in 15 patients (9 men; median age 67 years) were performed at 6 (37%) of 16 hospitals (Indiana University plus 15 other hospitals). Kidney masses (median diameter 32 mm; range 11-60 mm) were located in the upper (n = 12) and lower (n = 3) poles of the left (n = 10) and right (n = 5) kidneys, respectively. Initial mass detection was by previous imaging in 13 (87%) patients or by EUS in 2 (13%) patients. Results of EUS-FNA (median 3 passes; range 2-4 passes) in 13 (87%) procedures were diagnostic of (n = 7) or highly suspicious for (n = 1) renal cell carcinoma (RCC), atypical cells (n = 2), oncocytoma (n = 1), benign cyst (n = 1), and nondiagnostic (n = 1). No complications were encountered. Surgical resection confirmed RCC in 7 patients in whom preoperative EUS-FNA demonstrated RCC (n = 5) or oncocytoma (n = 1) or was not performed (n = 1). Limitations: Retrospective series, small number of patients. Conclusions: EUS-FNA of renal masses is rarely performed at the U.S. teaching hospitals surveyed. This technique appears safe and feasible and should be considered when results would affect patient management.

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