Evaluating the consistency of pharmacotherapy exposure by use of state-of-the-art techniques

Robert R. Bies, Marc R. Gastonguay, Kim C. Coley, Patricia D. Kroboth, Bruce G. Pollock

Research output: Contribution to journalArticle

16 Scopus citations


Objective: The authors examine the usefulness of population pharmacokinetics coupled with electronic compliance monitoring in evaluating consistency of exposure to pharmacotherapy. Adherence to pharmacotherapy can have a significant impact on drug response, especially in the treatment of schizophrenia and depression. Previous studies evaluating antipsychotics identified schizophrenic individuals with poor pharmacotherapy adherence as having a higher risk of rehospitalization. Other investigators have shown a relationship between pattern of taking selective serotoninreuptake inhibitors (SSRIs) and probability of a positive outcome. Therefore, it is important to measure adherence patterns in clinical trials evaluating these treatments and to incorporate this information into the research findings. Methods: Two multisite trials with atypical antipsychotics and antidepressants were simulated to evaluate, by use of population pharmacokinetic methods, the impact of electronic monitoring on measuring consistency of exposure to pharmacotherapy. One of the trials is ongoing and evaluates exposure to atypical antipsychotics, and the other is a proposed trial that examines exposure to an SSRI. Results: Erratic exposurepatterns were detected with population pharmacokinetic techniques in the absence of Electronic Medication Event Monitoring (MEMS™) data. In our simulations, the use of electronic monitoring improved the identification of atypical exposure by population pharmacokinetics both for the atypical antipsychotics and SSRIs. Conclusion: Our simulations demonstrate the potential usefulness of the combination of population pharmacokinetics with electronic monitoring as a robust method for accurately and precisely capturing both magnitude and consistency of pharmacotherapy exposure.

Original languageEnglish (US)
Pages (from-to)696-705
Number of pages10
JournalAmerican Journal of Geriatric Psychiatry
Issue number6
StatePublished - 2002

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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