Evaluating the effects of endocrine disrupters on endocrine function during development

Robert Bigsby, Robert E. Chapin, George P. Daston, Barbara J. Davis, Jack Gorski, L. Earl Gray, Kembra L. Howdeshell, R. Thomas Zoeller, Frederick S. Vom Saal

Research output: Contribution to journalArticle

131 Citations (Scopus)

Abstract

The major concerns with endocrine disrupters in the environment are based mostly on effects that have been observed on the developing embryo and fetus. The focus of the present manuscript is on disruption of three hormonal systems: estrogens, androgens, and thyroid hormones. These three hormonal systems have been well characterized with regard to their roles in normal development, and their actions during development are known to be perturbed by endocrine-disrupting chemicals. During development, organs are especially sensitive to low concentrations of the sex steroids and thyroid hormones. Changes induced by exposure to these hormones during development are often irreversible, in contrast with the reversible changes induced by transient hormone exposure in the adult. Although it is known that there are differences in embryonic/ fetal/neonatal versus adult endocrine responses, minimal experimental information is available to aid in characterizing the risk of endocrine disrupters with regard to a number of issues. Issues discussed here include the hypothesis of greater sensitivity of embryos/fetuses to endocrine disrupters, irreversible consequences of exposure before maturation of homeostatic systems and during periods of genetic imprinting, and quantitative information related to the shape of the dose-response curve for specific developmental phenomena.

Original languageEnglish
Pages (from-to)613-618
Number of pages6
JournalEnvironmental Health Perspectives
Volume107
Issue numberSUPPL. 4
StatePublished - 1999

Fingerprint

Endocrine disrupters
endocrine disruptor
Thyroid Hormones
hormone
Fetus
Embryonic Structures
Hormones
Genomic Imprinting
Endocrine Disruptors
Manuscripts
Gonadal Steroid Hormones
Androgens
embryo
Estrogens
imprinting
androgen
steroid
maturation
effect
exposure

Keywords

  • Androgen
  • Development
  • Embryo
  • Endocrine disrupters
  • Estrogens
  • Fetus
  • Thyroid

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health

Cite this

Bigsby, R., Chapin, R. E., Daston, G. P., Davis, B. J., Gorski, J., Gray, L. E., ... Vom Saal, F. S. (1999). Evaluating the effects of endocrine disrupters on endocrine function during development. Environmental Health Perspectives, 107(SUPPL. 4), 613-618.

Evaluating the effects of endocrine disrupters on endocrine function during development. / Bigsby, Robert; Chapin, Robert E.; Daston, George P.; Davis, Barbara J.; Gorski, Jack; Gray, L. Earl; Howdeshell, Kembra L.; Thomas Zoeller, R.; Vom Saal, Frederick S.

In: Environmental Health Perspectives, Vol. 107, No. SUPPL. 4, 1999, p. 613-618.

Research output: Contribution to journalArticle

Bigsby, R, Chapin, RE, Daston, GP, Davis, BJ, Gorski, J, Gray, LE, Howdeshell, KL, Thomas Zoeller, R & Vom Saal, FS 1999, 'Evaluating the effects of endocrine disrupters on endocrine function during development', Environmental Health Perspectives, vol. 107, no. SUPPL. 4, pp. 613-618.
Bigsby R, Chapin RE, Daston GP, Davis BJ, Gorski J, Gray LE et al. Evaluating the effects of endocrine disrupters on endocrine function during development. Environmental Health Perspectives. 1999;107(SUPPL. 4):613-618.
Bigsby, Robert ; Chapin, Robert E. ; Daston, George P. ; Davis, Barbara J. ; Gorski, Jack ; Gray, L. Earl ; Howdeshell, Kembra L. ; Thomas Zoeller, R. ; Vom Saal, Frederick S. / Evaluating the effects of endocrine disrupters on endocrine function during development. In: Environmental Health Perspectives. 1999 ; Vol. 107, No. SUPPL. 4. pp. 613-618.
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