Evaluation of 308-nm monochromatic excimer light in the treatment of psoriasis vulgaris and palmoplantar psoriasis

Ling Han, Ally-Khan Somani, Qiong Huang, Xu Fang, Yi Jin, Lei Hong Xiang, Zhi Zhong Zheng

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: The purpose of this study is to evaluate the efficacy and safety of 308-nm monochromatic excimer light (MEL) in the treatment of psoriasis vulgaris and palmoplantar psoriasis. Methods: Thirty-five patients with psoriasis vulgaris and 15 patients with palmoplantar psoriasis were recruited for this study. Thirty patients with psoriasis vulgaris completed a total of 16 treatments with 308-nm MEL twice a week, and 15 patients palmoplantar psoriasis completed 25 treatments administered once weekly. The clinical response to therapy and adverse effects were recorded. Results: Patients with psoriasis vulgaris (n = 30) showed a 74.6% improvement in the mean psoriasis area and severity index score after a total of 16 MEL treatments (2 ×/week) with 36.7% of the patients (n = 11) achieving clearance. Patients with palmoplantar psoriasis (n = 15) showed a 52.5% improvement in the mean severity index score after a total of 25 MEL treatments (1 ×/week) with only one patient (6.7%) achieving clearance. The MEL therapy was well tolerated with a low incidence of side effects, which included pruritus, erythema and blister formation. Conclusion: The 308-nm MEL can be utilized as an effective and safe treatment modality for patients with mild-to-moderate psoriasis vulgaris and palmoplantar psoriasis.

Original languageEnglish (US)
Pages (from-to)231-236
Number of pages6
JournalPhotodermatology Photoimmunology and Photomedicine
Volume24
Issue number5
DOIs
StatePublished - 2008
Externally publishedYes

Fingerprint

Psoriasis
Light
Therapeutics
Phototherapy
Erythema
Blister
Pruritus
Safety
Incidence

Keywords

  • 308 nm
  • Monochromatic excimer light
  • Phototherapy
  • Psoriasis

ASJC Scopus subject areas

  • Dermatology
  • Immunology

Cite this

Evaluation of 308-nm monochromatic excimer light in the treatment of psoriasis vulgaris and palmoplantar psoriasis. / Han, Ling; Somani, Ally-Khan; Huang, Qiong; Fang, Xu; Jin, Yi; Xiang, Lei Hong; Zheng, Zhi Zhong.

In: Photodermatology Photoimmunology and Photomedicine, Vol. 24, No. 5, 2008, p. 231-236.

Research output: Contribution to journalArticle

Han, Ling ; Somani, Ally-Khan ; Huang, Qiong ; Fang, Xu ; Jin, Yi ; Xiang, Lei Hong ; Zheng, Zhi Zhong. / Evaluation of 308-nm monochromatic excimer light in the treatment of psoriasis vulgaris and palmoplantar psoriasis. In: Photodermatology Photoimmunology and Photomedicine. 2008 ; Vol. 24, No. 5. pp. 231-236.
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abstract = "Background: The purpose of this study is to evaluate the efficacy and safety of 308-nm monochromatic excimer light (MEL) in the treatment of psoriasis vulgaris and palmoplantar psoriasis. Methods: Thirty-five patients with psoriasis vulgaris and 15 patients with palmoplantar psoriasis were recruited for this study. Thirty patients with psoriasis vulgaris completed a total of 16 treatments with 308-nm MEL twice a week, and 15 patients palmoplantar psoriasis completed 25 treatments administered once weekly. The clinical response to therapy and adverse effects were recorded. Results: Patients with psoriasis vulgaris (n = 30) showed a 74.6{\%} improvement in the mean psoriasis area and severity index score after a total of 16 MEL treatments (2 ×/week) with 36.7{\%} of the patients (n = 11) achieving clearance. Patients with palmoplantar psoriasis (n = 15) showed a 52.5{\%} improvement in the mean severity index score after a total of 25 MEL treatments (1 ×/week) with only one patient (6.7{\%}) achieving clearance. The MEL therapy was well tolerated with a low incidence of side effects, which included pruritus, erythema and blister formation. Conclusion: The 308-nm MEL can be utilized as an effective and safe treatment modality for patients with mild-to-moderate psoriasis vulgaris and palmoplantar psoriasis.",
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AU - Xiang, Lei Hong

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