Evaluation of 308-nm monochromatic excimer light in the treatment of psoriasis vulgaris and palmoplantar psoriasis

Ling Han, Ally Khan Somani, Qiong Huang, Xu Fang, Yi Jin, Lei Hong Xiang, Zhi Zhong Zheng

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Background: The purpose of this study is to evaluate the efficacy and safety of 308-nm monochromatic excimer light (MEL) in the treatment of psoriasis vulgaris and palmoplantar psoriasis. Methods: Thirty-five patients with psoriasis vulgaris and 15 patients with palmoplantar psoriasis were recruited for this study. Thirty patients with psoriasis vulgaris completed a total of 16 treatments with 308-nm MEL twice a week, and 15 patients palmoplantar psoriasis completed 25 treatments administered once weekly. The clinical response to therapy and adverse effects were recorded. Results: Patients with psoriasis vulgaris (n = 30) showed a 74.6% improvement in the mean psoriasis area and severity index score after a total of 16 MEL treatments (2 ×/week) with 36.7% of the patients (n = 11) achieving clearance. Patients with palmoplantar psoriasis (n = 15) showed a 52.5% improvement in the mean severity index score after a total of 25 MEL treatments (1 ×/week) with only one patient (6.7%) achieving clearance. The MEL therapy was well tolerated with a low incidence of side effects, which included pruritus, erythema and blister formation. Conclusion: The 308-nm MEL can be utilized as an effective and safe treatment modality for patients with mild-to-moderate psoriasis vulgaris and palmoplantar psoriasis.

Original languageEnglish (US)
Pages (from-to)231-236
Number of pages6
JournalPhotodermatology Photoimmunology and Photomedicine
Volume24
Issue number5
DOIs
StatePublished - Sep 23 2008
Externally publishedYes

Keywords

  • 308 nm
  • Monochromatic excimer light
  • Phototherapy
  • Psoriasis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Radiology Nuclear Medicine and imaging
  • Dermatology

Fingerprint Dive into the research topics of 'Evaluation of 308-nm monochromatic excimer light in the treatment of psoriasis vulgaris and palmoplantar psoriasis'. Together they form a unique fingerprint.

Cite this