Evaluation of a desensitizing test dentifrice using an in situ erosion remineralization model

D. T. Zero, A. T. Hara, S. A. Kelly, C. González-Cabezas, G. J. Eckert, A. P. Barlow, S. C. Mason

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53 Scopus citations


Objective: To evaluate, in an in situ remineralization model, the ability of a low abrasion fluoride dentifrice containing potassium nitrate to enhance the remineralization of enamel that was previously subjected to an in vitro dietary erosion challenge. Methodology: Thirteen subjects completed a single-blind (to specimen analyst) crossover design study with four randomly assigned dentifrice treatments: placebo dentifrice (0 ppm F; PD); dose response control dentifrice (250 ppm F; DD); clinically tested fluoride dentifrice (1100 ppm F; FD); and test dentifrice (1150 ppm F + 5% KNO3; TD). Each subject wore a palatal appliance holding eight bovine enamel blocks that were previously exposed for 25 minutes to an in vitro erosive challenge with grapefruit juice. Surface microhardness (SMH) was determined prior to the erosive challenge (baseline), after the in vitro erosive challenge, after in situ remineralization, and after a second in vitro erosive challenge. Statistical analyses included ANOVA and pair-wise comparisons between treatments, testing at a 5% significance level. Results: The mean percent SMH recovery (SD) was 20.4 (7.7)afor PD; 27.4 (5.9)bfor DD; 29.5 (8.9)bcfor FD; 33.4 (6.7)cfor TD. The mean percent net erosion resistance (SD) was -57.7 (10.8)afor PD; -41.3 (11.6)bfor DD; -28.7 (9.7)cfor FD; -23.6 (7.3)cfor TD. Different superscript letters following the means imply statistically significant differences between groups for each response. Conclusion: The test dentifrice was shown to significantly enhance the remineralization of enamel previously subjected to an erosion challenge.

Original languageEnglish (US)
Pages (from-to)112-116
Number of pages5
JournalJournal of Clinical Dentistry
Issue number4
StatePublished - Jan 1 2006


ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Zero, D. T., Hara, A. T., Kelly, S. A., González-Cabezas, C., Eckert, G. J., Barlow, A. P., & Mason, S. C. (2006). Evaluation of a desensitizing test dentifrice using an in situ erosion remineralization model. Journal of Clinical Dentistry, 17(4), 112-116.