Evaluation of a mixed meal test for diagnosis and characterization of pancrEaTogEniC diabetes secondary to pancreatic cancer and chronic pancreatitis: Rationale and methodology for the DETECT study from the consortium for the study of chronic pancreatitis, diabetes, and pancreatic cancer

Phil A. Hart, Dana K. Andersen, Kieren J. Mather, Alicia C. Castonguay, Mandeep Bajaj, Melena D. Bellin, David Bradley, Noemy Contreras, Aida Habtezion, Murray Korc, Yogish Kudva, Maxim S. Petrov, David C. Whitcomb, Dhiraj Yadav, Ying Yuan, Jo Ann S. Rinaudo, Sudhir Srivastava, Jose Serrano, Mark O. Goodarzi

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Pancreatogenic diabetes mellitus is most commonly the result of chronic pancreatitis but can also occur secondary to pancreatic cancer. The early identification of pancreatogenic diabetes and distinction from the more prevalent type 2 diabetes are clinically significant; however, currently, there is no validated method to differentiate these diabetes subtypes. We describe a study, "Evaluation of a Mixed Meal Test for Diagnosis and Characterization of PancrEaTogEniC DiabeTes Secondary to Pancreatic Cancer and Chronic Pancreatitis: The DETECT study," that seeks to address this knowledge gap. The DETECT study is a multicenter study that will examine differences in hormone and glucose excursions after a mixed meal test. The study will also create a biorepository that will be used to evaluate novel diagnostic biomarkers for differentiating these diabetes subtypes.

Original languageEnglish (US)
Pages (from-to)1239-1243
Number of pages5
JournalPancreas
Volume47
Issue number10
DOIs
StatePublished - Nov 1 2018

    Fingerprint

Keywords

  • glucagon
  • incretin hormone
  • insulin
  • pancreatic polypeptide
  • type 3c diabetes mellitus

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

Cite this

Hart, P. A., Andersen, D. K., Mather, K. J., Castonguay, A. C., Bajaj, M., Bellin, M. D., Bradley, D., Contreras, N., Habtezion, A., Korc, M., Kudva, Y., Petrov, M. S., Whitcomb, D. C., Yadav, D., Yuan, Y., Rinaudo, J. A. S., Srivastava, S., Serrano, J., & Goodarzi, M. O. (2018). Evaluation of a mixed meal test for diagnosis and characterization of pancrEaTogEniC diabetes secondary to pancreatic cancer and chronic pancreatitis: Rationale and methodology for the DETECT study from the consortium for the study of chronic pancreatitis, diabetes, and pancreatic cancer. Pancreas, 47(10), 1239-1243. https://doi.org/10.1097/MPA.0000000000001168