Evaluation of a new range of light-activated surgical adhesives for tissue repair in a porcine model

J. N. Riley, D. E. Hodges, K. L. March, K. M. McNally-Heintzelman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

An in vitro study was conducted to determine the feasibility of using a new range of light-activated surgical adhesives for incision repair in a wide range of tissue types. Biodegradable polymer membranes of controlled porosity were fabricated with poly(L-lactic-co-glycolic acid) (PLGA) and salt particles using a solvent-casting and particulate-leaching technique. The porous membranes were doped with protein solder composed of 50%(w/v) bovine serum albumin solder and 0.5mg/ml indocyanine green (ICG) dye mixed in deionized water. Tissue incisions were repaired using the surgical adhesive in conjunction with an 805-nm diode laser. Nine organs were tested ranging from skin to liver to the small intestine, as well as the coronary, pulmonary, carotid, femoral and splenetic arteries. Acute breaking strengths were measured and the data were analyzed by Student's T-test. Repairs formed on the small intestine were most successful followed by spleen, atrium, kidney, muscle and skin. The strongest vascular repairs were achieved in the carotid artery and femoral artery. The new surgical adhesive could possibly be used as a simple and effective method to stop bleeding and repair tissue quickly in an emergency situation, or as a substitute to mechanical staples or sutures in many clinical applications.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsR.R. Anderson, K.E. Bartels, L.S. Bass, C.G. Garrett
Pages220-225
Number of pages6
Volume4244
DOIs
StatePublished - 2001
EventLaser in Surgery: Advanced Characterization, Therapeutics, and Systems XI - San Jose,CA, United States
Duration: Jun 20 2001Jun 23 2001

Other

OtherLaser in Surgery: Advanced Characterization, Therapeutics, and Systems XI
CountryUnited States
CitySan Jose,CA
Period6/20/016/23/01

Fingerprint

arteries
adhesives
Adhesives
intestines
Repair
Tissue
solders
evaluation
Soldering alloys
membranes
bleeding
Skin
spleen
plasticizers
emergencies
kidneys
leaching
muscles
Membranes
albumins

Keywords

  • Albumin protein solder
  • Diode laser
  • Indocyanine green dye
  • Polymer membrane
  • Repair strength

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Riley, J. N., Hodges, D. E., March, K. L., & McNally-Heintzelman, K. M. (2001). Evaluation of a new range of light-activated surgical adhesives for tissue repair in a porcine model. In R. R. Anderson, K. E. Bartels, L. S. Bass, & C. G. Garrett (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4244, pp. 220-225) https://doi.org/10.1117/12.427795

Evaluation of a new range of light-activated surgical adhesives for tissue repair in a porcine model. / Riley, J. N.; Hodges, D. E.; March, K. L.; McNally-Heintzelman, K. M.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / R.R. Anderson; K.E. Bartels; L.S. Bass; C.G. Garrett. Vol. 4244 2001. p. 220-225.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Riley, JN, Hodges, DE, March, KL & McNally-Heintzelman, KM 2001, Evaluation of a new range of light-activated surgical adhesives for tissue repair in a porcine model. in RR Anderson, KE Bartels, LS Bass & CG Garrett (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 4244, pp. 220-225, Laser in Surgery: Advanced Characterization, Therapeutics, and Systems XI, San Jose,CA, United States, 6/20/01. https://doi.org/10.1117/12.427795
Riley JN, Hodges DE, March KL, McNally-Heintzelman KM. Evaluation of a new range of light-activated surgical adhesives for tissue repair in a porcine model. In Anderson RR, Bartels KE, Bass LS, Garrett CG, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 4244. 2001. p. 220-225 https://doi.org/10.1117/12.427795
Riley, J. N. ; Hodges, D. E. ; March, K. L. ; McNally-Heintzelman, K. M. / Evaluation of a new range of light-activated surgical adhesives for tissue repair in a porcine model. Proceedings of SPIE - The International Society for Optical Engineering. editor / R.R. Anderson ; K.E. Bartels ; L.S. Bass ; C.G. Garrett. Vol. 4244 2001. pp. 220-225
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