Evaluation of a potential generator-produced PET tracer for cerebral perfusion imaging: Single-pass cerebral extraction measurements and imaging with radiolabeled Cu-PTSM

C. J. Mathias, M. J. Welch, M. E. Raichle, M. A. Mintun, L. L. Lich, A. H. McGuire, K. R. Zinn, E. K. John, Mark Green

Research output: Contribution to journalArticle

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Abstract

Copper(II) pyruvaldehyde bis(N4-methylthiosemicarbazone) (Cu-PTSM), copper(II) pyruvaldehyde bis(N4-dimethylthiosemicarbazone) (Cu-PTSM2), and copper(II) ethylglyoxal bis(N4-methylthiosemicarbazone) (Cu-ETSM), have been proposed as PET tracers for cerebral blood flow (CBF) when labeled with generator-produced 62Cu (t( 1/2 ) = 9.7 min). To evaluate the potential of Cu-PTSM for CBF PET studies, baboon single-pass cerebral extraction measurements and PET imaging were carried out with the use of 67Cu (t( 1/2 ) = 2.6 dyas) and 64Cu (T( 1/2 ) = 12.7 hr), respectively. All three chelates were extracted into the brain with high efficiency. There was some clearance of all chelates in the 10-50-sec time frame and Cu-PTSM2 continued to clear. Cu-PTSM and Cu-ETSM have high residual brain activity. PET imaging of baboon brain was carried out with the use of [64Cu]-Cu-PTSM. For comparison with the 64Cu brain image, a CBF )15O-labeled water) image (40 sec) was first obtained. Qualitatively, the H2 15O and [64Cu]-Cu-PTSM images were very similar; for example, a comparison of gray to white matter uptake resulted in ratios of 2.42 for H2 15O and 2.67 for Cu-PTSM. No redistribution of 64Cu was observed in 2 hr of imaging, as was predicted from the single-pass study results. Quantitative determination of blood flow using Cu-PTSM showed good agreement with blood flow determined with H2 15O. This data suggests that [62Cu]-Cu-PTSM may be a useful generator-produced radiopharmaceutical for blood flow studies with PET.

Original languageEnglish (US)
Pages (from-to)351-359
Number of pages9
JournalJournal of Nuclear Medicine
Volume31
Issue number3
StatePublished - 1990
Externally publishedYes

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Perfusion Imaging
Cerebrovascular Circulation
Pyruvaldehyde
Copper
Papio
Brain
Radiopharmaceuticals
copper pyruvaldehyde bis(N(4)-methylthiosemicarbazone) complex
Neuroimaging
Water

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Evaluation of a potential generator-produced PET tracer for cerebral perfusion imaging : Single-pass cerebral extraction measurements and imaging with radiolabeled Cu-PTSM. / Mathias, C. J.; Welch, M. J.; Raichle, M. E.; Mintun, M. A.; Lich, L. L.; McGuire, A. H.; Zinn, K. R.; John, E. K.; Green, Mark.

In: Journal of Nuclear Medicine, Vol. 31, No. 3, 1990, p. 351-359.

Research output: Contribution to journalArticle

Mathias, C. J. ; Welch, M. J. ; Raichle, M. E. ; Mintun, M. A. ; Lich, L. L. ; McGuire, A. H. ; Zinn, K. R. ; John, E. K. ; Green, Mark. / Evaluation of a potential generator-produced PET tracer for cerebral perfusion imaging : Single-pass cerebral extraction measurements and imaging with radiolabeled Cu-PTSM. In: Journal of Nuclear Medicine. 1990 ; Vol. 31, No. 3. pp. 351-359.
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abstract = "Copper(II) pyruvaldehyde bis(N4-methylthiosemicarbazone) (Cu-PTSM), copper(II) pyruvaldehyde bis(N4-dimethylthiosemicarbazone) (Cu-PTSM2), and copper(II) ethylglyoxal bis(N4-methylthiosemicarbazone) (Cu-ETSM), have been proposed as PET tracers for cerebral blood flow (CBF) when labeled with generator-produced 62Cu (t( 1/2 ) = 9.7 min). To evaluate the potential of Cu-PTSM for CBF PET studies, baboon single-pass cerebral extraction measurements and PET imaging were carried out with the use of 67Cu (t( 1/2 ) = 2.6 dyas) and 64Cu (T( 1/2 ) = 12.7 hr), respectively. All three chelates were extracted into the brain with high efficiency. There was some clearance of all chelates in the 10-50-sec time frame and Cu-PTSM2 continued to clear. Cu-PTSM and Cu-ETSM have high residual brain activity. PET imaging of baboon brain was carried out with the use of [64Cu]-Cu-PTSM. For comparison with the 64Cu brain image, a CBF )15O-labeled water) image (40 sec) was first obtained. Qualitatively, the H2 15O and [64Cu]-Cu-PTSM images were very similar; for example, a comparison of gray to white matter uptake resulted in ratios of 2.42 for H2 15O and 2.67 for Cu-PTSM. No redistribution of 64Cu was observed in 2 hr of imaging, as was predicted from the single-pass study results. Quantitative determination of blood flow using Cu-PTSM showed good agreement with blood flow determined with H2 15O. This data suggests that [62Cu]-Cu-PTSM may be a useful generator-produced radiopharmaceutical for blood flow studies with PET.",
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AU - Mathias, C. J.

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AU - Raichle, M. E.

AU - Mintun, M. A.

AU - Lich, L. L.

AU - McGuire, A. H.

AU - Zinn, K. R.

AU - John, E. K.

AU - Green, Mark

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