Evaluation of a ventricular assist device system

Stability in a proton beam therapy

Michael S. Gossman, Joel D. Graham, Indra J. Das, Chee Wai Cheng, Len Coutinho, Dan Tamez, Jeffrey A. Larose

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Inadequate research exists regarding testing of a ventricular assist device (VAD) for susceptibility to radiation damage. Specifically, minimal data are available to radiation oncologists prescribing treatment plans for patients with an implanted VAD. As the number of implanted devices increases, patients requiring radiation at tissue sites near or at the device will increase. The purpose of this study is to provide the first analysis of radiation effects of proton beams on VADs. Five left VAD (LVAD) pumps (HeartWare Inc., Miami Lakes, FL) were exposed to proton beam radiation at a calibrated dose rate of 5 Gy/min up to a cumulative dose of 70 Gy. The Heartware LVAD pump recorded parameters including power (W), speed (revolutions/min), and estimated flow (L/min). Analysis of collected data after each irradiation found no deviation in pump parameters from baseline values. The Heartware LVAD pump exhibited no change in device function when directly irradiated by a high energy proton beam. Secondary neutron fluence created in the proton beam during irradiation had no effect on external components including the system controller and batteries powering the Heartware LVAD.

Original languageEnglish
Pages (from-to)597-600
Number of pages4
JournalASAIO Journal
Volume58
Issue number6
DOIs
StatePublished - Nov 2012

Fingerprint

Proton Therapy
Heart-Assist Devices
Proton beams
System stability
Protons
Pumps
Radiation
Equipment and Supplies
Left ventricular assist devices
Irradiation
Radiation effects
Radiation damage
Radiation Effects
Neutrons
Lakes
Dosimetry
Tissue
Controllers
Proton beam therapy
Testing

Keywords

  • HeartWare left ventricular assist device
  • left ventricular assist device
  • proton beam treatment
  • radiation
  • ventricular assist device

ASJC Scopus subject areas

  • Biophysics
  • Biomaterials
  • Bioengineering
  • Biomedical Engineering
  • Medicine(all)

Cite this

Gossman, M. S., Graham, J. D., Das, I. J., Cheng, C. W., Coutinho, L., Tamez, D., & Larose, J. A. (2012). Evaluation of a ventricular assist device system: Stability in a proton beam therapy. ASAIO Journal, 58(6), 597-600. https://doi.org/10.1097/MAT.0b013e31826feeca

Evaluation of a ventricular assist device system : Stability in a proton beam therapy. / Gossman, Michael S.; Graham, Joel D.; Das, Indra J.; Cheng, Chee Wai; Coutinho, Len; Tamez, Dan; Larose, Jeffrey A.

In: ASAIO Journal, Vol. 58, No. 6, 11.2012, p. 597-600.

Research output: Contribution to journalArticle

Gossman, MS, Graham, JD, Das, IJ, Cheng, CW, Coutinho, L, Tamez, D & Larose, JA 2012, 'Evaluation of a ventricular assist device system: Stability in a proton beam therapy', ASAIO Journal, vol. 58, no. 6, pp. 597-600. https://doi.org/10.1097/MAT.0b013e31826feeca
Gossman MS, Graham JD, Das IJ, Cheng CW, Coutinho L, Tamez D et al. Evaluation of a ventricular assist device system: Stability in a proton beam therapy. ASAIO Journal. 2012 Nov;58(6):597-600. https://doi.org/10.1097/MAT.0b013e31826feeca
Gossman, Michael S. ; Graham, Joel D. ; Das, Indra J. ; Cheng, Chee Wai ; Coutinho, Len ; Tamez, Dan ; Larose, Jeffrey A. / Evaluation of a ventricular assist device system : Stability in a proton beam therapy. In: ASAIO Journal. 2012 ; Vol. 58, No. 6. pp. 597-600.
@article{8ca316e9393b45459af5ed1ad8fc4cfe,
title = "Evaluation of a ventricular assist device system: Stability in a proton beam therapy",
abstract = "Inadequate research exists regarding testing of a ventricular assist device (VAD) for susceptibility to radiation damage. Specifically, minimal data are available to radiation oncologists prescribing treatment plans for patients with an implanted VAD. As the number of implanted devices increases, patients requiring radiation at tissue sites near or at the device will increase. The purpose of this study is to provide the first analysis of radiation effects of proton beams on VADs. Five left VAD (LVAD) pumps (HeartWare Inc., Miami Lakes, FL) were exposed to proton beam radiation at a calibrated dose rate of 5 Gy/min up to a cumulative dose of 70 Gy. The Heartware LVAD pump recorded parameters including power (W), speed (revolutions/min), and estimated flow (L/min). Analysis of collected data after each irradiation found no deviation in pump parameters from baseline values. The Heartware LVAD pump exhibited no change in device function when directly irradiated by a high energy proton beam. Secondary neutron fluence created in the proton beam during irradiation had no effect on external components including the system controller and batteries powering the Heartware LVAD.",
keywords = "HeartWare left ventricular assist device, left ventricular assist device, proton beam treatment, radiation, ventricular assist device",
author = "Gossman, {Michael S.} and Graham, {Joel D.} and Das, {Indra J.} and Cheng, {Chee Wai} and Len Coutinho and Dan Tamez and Larose, {Jeffrey A.}",
year = "2012",
month = "11",
doi = "10.1097/MAT.0b013e31826feeca",
language = "English",
volume = "58",
pages = "597--600",
journal = "ASAIO Journal",
issn = "1058-2916",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Evaluation of a ventricular assist device system

T2 - Stability in a proton beam therapy

AU - Gossman, Michael S.

AU - Graham, Joel D.

AU - Das, Indra J.

AU - Cheng, Chee Wai

AU - Coutinho, Len

AU - Tamez, Dan

AU - Larose, Jeffrey A.

PY - 2012/11

Y1 - 2012/11

N2 - Inadequate research exists regarding testing of a ventricular assist device (VAD) for susceptibility to radiation damage. Specifically, minimal data are available to radiation oncologists prescribing treatment plans for patients with an implanted VAD. As the number of implanted devices increases, patients requiring radiation at tissue sites near or at the device will increase. The purpose of this study is to provide the first analysis of radiation effects of proton beams on VADs. Five left VAD (LVAD) pumps (HeartWare Inc., Miami Lakes, FL) were exposed to proton beam radiation at a calibrated dose rate of 5 Gy/min up to a cumulative dose of 70 Gy. The Heartware LVAD pump recorded parameters including power (W), speed (revolutions/min), and estimated flow (L/min). Analysis of collected data after each irradiation found no deviation in pump parameters from baseline values. The Heartware LVAD pump exhibited no change in device function when directly irradiated by a high energy proton beam. Secondary neutron fluence created in the proton beam during irradiation had no effect on external components including the system controller and batteries powering the Heartware LVAD.

AB - Inadequate research exists regarding testing of a ventricular assist device (VAD) for susceptibility to radiation damage. Specifically, minimal data are available to radiation oncologists prescribing treatment plans for patients with an implanted VAD. As the number of implanted devices increases, patients requiring radiation at tissue sites near or at the device will increase. The purpose of this study is to provide the first analysis of radiation effects of proton beams on VADs. Five left VAD (LVAD) pumps (HeartWare Inc., Miami Lakes, FL) were exposed to proton beam radiation at a calibrated dose rate of 5 Gy/min up to a cumulative dose of 70 Gy. The Heartware LVAD pump recorded parameters including power (W), speed (revolutions/min), and estimated flow (L/min). Analysis of collected data after each irradiation found no deviation in pump parameters from baseline values. The Heartware LVAD pump exhibited no change in device function when directly irradiated by a high energy proton beam. Secondary neutron fluence created in the proton beam during irradiation had no effect on external components including the system controller and batteries powering the Heartware LVAD.

KW - HeartWare left ventricular assist device

KW - left ventricular assist device

KW - proton beam treatment

KW - radiation

KW - ventricular assist device

UR - http://www.scopus.com/inward/record.url?scp=84868666951&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84868666951&partnerID=8YFLogxK

U2 - 10.1097/MAT.0b013e31826feeca

DO - 10.1097/MAT.0b013e31826feeca

M3 - Article

VL - 58

SP - 597

EP - 600

JO - ASAIO Journal

JF - ASAIO Journal

SN - 1058-2916

IS - 6

ER -