Evaluation of airway reactivity and immune characteristics as risk factors for wheezing early in life

Weiguo Yao, Florencia M. Barbé-Tuana, Conrado J. Llapur, Marcus H. Jones, Christina Tiller, Risa Kimmel, Jeffrey Kisling, Evelyn T. Nguyen, James Nguyen, Zhangsheng Yu, Mark H. Kaplan, Robert S. Tepper

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: Childhood asthma is most often characterized by recurrent wheezing, airway hyperreactivity, and atopy; however, our understanding of these relationships from early in life remains unclear. Respiratory tract illnesses and atopic sensitization early in life might produce an interaction between innate and acquired immune responses, leading to airway inflammation and heightened airway reactivity. Objective: We hypothesized that premorbid airway reactivity and immunologic characteristics of infants without prior episodes of wheezing would be associated with subsequent wheezing during a 1-year follow-up. Methods: One hundred sixteen infants with chronic dermatitis were enrolled before episodes of wheezing. Airway reactivity, allergen-specific IgE levels, cytokine production by stimulated PBMCs, and percentages of dendritic cells were measured on entry, and airway reactivity was reassessed at the 1-year follow-up. Linear regression models were used to evaluate a predictor's effect on continuous outcomes. Results: Milk sensitization, egg sensitization, or both were associated with heightened airway reactivity before wheezing and after the onset of wheezing; however, these factors were not associated with an increased risk of wheezing. There was an interaction between initial airway reactivity and wheezing as a determinant of airway reactivity at follow-up. In addition, cytokine production by stimulated PBMCs was a risk factor for wheezing, whereas increased percentages of conventional dendritic cells were protective against wheezing. Conclusion: Our data in a selected cohort of infants support a model with multiple risk factors for subsequent wheezing that are independent of initial airway reactivity; however, the causative factors that produce wheezing very early in life might contribute to heightened airway reactivity.

Original languageEnglish (US)
Pages (from-to)483-488.e1
JournalJournal of Allergy and Clinical Immunology
Volume126
Issue number3
DOIs
StatePublished - Sep 2010

Fingerprint

Respiratory Sounds
Dendritic Cells
Linear Models
Cytokines
Dermatitis
Innate Immunity
Respiratory System
Allergens
Immunoglobulin E
Ovum
Milk
Asthma
Inflammation

Keywords

  • airway reactivity
  • atopy
  • cytokines
  • dendritic cells
  • dermatitis
  • food allergy
  • Infants
  • wheezing

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Medicine(all)

Cite this

Evaluation of airway reactivity and immune characteristics as risk factors for wheezing early in life. / Yao, Weiguo; Barbé-Tuana, Florencia M.; Llapur, Conrado J.; Jones, Marcus H.; Tiller, Christina; Kimmel, Risa; Kisling, Jeffrey; Nguyen, Evelyn T.; Nguyen, James; Yu, Zhangsheng; Kaplan, Mark H.; Tepper, Robert S.

In: Journal of Allergy and Clinical Immunology, Vol. 126, No. 3, 09.2010, p. 483-488.e1.

Research output: Contribution to journalArticle

Yao, W, Barbé-Tuana, FM, Llapur, CJ, Jones, MH, Tiller, C, Kimmel, R, Kisling, J, Nguyen, ET, Nguyen, J, Yu, Z, Kaplan, MH & Tepper, RS 2010, 'Evaluation of airway reactivity and immune characteristics as risk factors for wheezing early in life', Journal of Allergy and Clinical Immunology, vol. 126, no. 3, pp. 483-488.e1. https://doi.org/10.1016/j.jaci.2010.06.028
Yao, Weiguo ; Barbé-Tuana, Florencia M. ; Llapur, Conrado J. ; Jones, Marcus H. ; Tiller, Christina ; Kimmel, Risa ; Kisling, Jeffrey ; Nguyen, Evelyn T. ; Nguyen, James ; Yu, Zhangsheng ; Kaplan, Mark H. ; Tepper, Robert S. / Evaluation of airway reactivity and immune characteristics as risk factors for wheezing early in life. In: Journal of Allergy and Clinical Immunology. 2010 ; Vol. 126, No. 3. pp. 483-488.e1.
@article{435096770dac47d799fd81979c51dad5,
title = "Evaluation of airway reactivity and immune characteristics as risk factors for wheezing early in life",
abstract = "Background: Childhood asthma is most often characterized by recurrent wheezing, airway hyperreactivity, and atopy; however, our understanding of these relationships from early in life remains unclear. Respiratory tract illnesses and atopic sensitization early in life might produce an interaction between innate and acquired immune responses, leading to airway inflammation and heightened airway reactivity. Objective: We hypothesized that premorbid airway reactivity and immunologic characteristics of infants without prior episodes of wheezing would be associated with subsequent wheezing during a 1-year follow-up. Methods: One hundred sixteen infants with chronic dermatitis were enrolled before episodes of wheezing. Airway reactivity, allergen-specific IgE levels, cytokine production by stimulated PBMCs, and percentages of dendritic cells were measured on entry, and airway reactivity was reassessed at the 1-year follow-up. Linear regression models were used to evaluate a predictor's effect on continuous outcomes. Results: Milk sensitization, egg sensitization, or both were associated with heightened airway reactivity before wheezing and after the onset of wheezing; however, these factors were not associated with an increased risk of wheezing. There was an interaction between initial airway reactivity and wheezing as a determinant of airway reactivity at follow-up. In addition, cytokine production by stimulated PBMCs was a risk factor for wheezing, whereas increased percentages of conventional dendritic cells were protective against wheezing. Conclusion: Our data in a selected cohort of infants support a model with multiple risk factors for subsequent wheezing that are independent of initial airway reactivity; however, the causative factors that produce wheezing very early in life might contribute to heightened airway reactivity.",
keywords = "airway reactivity, atopy, cytokines, dendritic cells, dermatitis, food allergy, Infants, wheezing",
author = "Weiguo Yao and Barb{\'e}-Tuana, {Florencia M.} and Llapur, {Conrado J.} and Jones, {Marcus H.} and Christina Tiller and Risa Kimmel and Jeffrey Kisling and Nguyen, {Evelyn T.} and James Nguyen and Zhangsheng Yu and Kaplan, {Mark H.} and Tepper, {Robert S.}",
year = "2010",
month = "9",
doi = "10.1016/j.jaci.2010.06.028",
language = "English (US)",
volume = "126",
pages = "483--488.e1",
journal = "Journal of Allergy and Clinical Immunology",
issn = "0091-6749",
publisher = "Mosby Inc.",
number = "3",

}

TY - JOUR

T1 - Evaluation of airway reactivity and immune characteristics as risk factors for wheezing early in life

AU - Yao, Weiguo

AU - Barbé-Tuana, Florencia M.

AU - Llapur, Conrado J.

AU - Jones, Marcus H.

AU - Tiller, Christina

AU - Kimmel, Risa

AU - Kisling, Jeffrey

AU - Nguyen, Evelyn T.

AU - Nguyen, James

AU - Yu, Zhangsheng

AU - Kaplan, Mark H.

AU - Tepper, Robert S.

PY - 2010/9

Y1 - 2010/9

N2 - Background: Childhood asthma is most often characterized by recurrent wheezing, airway hyperreactivity, and atopy; however, our understanding of these relationships from early in life remains unclear. Respiratory tract illnesses and atopic sensitization early in life might produce an interaction between innate and acquired immune responses, leading to airway inflammation and heightened airway reactivity. Objective: We hypothesized that premorbid airway reactivity and immunologic characteristics of infants without prior episodes of wheezing would be associated with subsequent wheezing during a 1-year follow-up. Methods: One hundred sixteen infants with chronic dermatitis were enrolled before episodes of wheezing. Airway reactivity, allergen-specific IgE levels, cytokine production by stimulated PBMCs, and percentages of dendritic cells were measured on entry, and airway reactivity was reassessed at the 1-year follow-up. Linear regression models were used to evaluate a predictor's effect on continuous outcomes. Results: Milk sensitization, egg sensitization, or both were associated with heightened airway reactivity before wheezing and after the onset of wheezing; however, these factors were not associated with an increased risk of wheezing. There was an interaction between initial airway reactivity and wheezing as a determinant of airway reactivity at follow-up. In addition, cytokine production by stimulated PBMCs was a risk factor for wheezing, whereas increased percentages of conventional dendritic cells were protective against wheezing. Conclusion: Our data in a selected cohort of infants support a model with multiple risk factors for subsequent wheezing that are independent of initial airway reactivity; however, the causative factors that produce wheezing very early in life might contribute to heightened airway reactivity.

AB - Background: Childhood asthma is most often characterized by recurrent wheezing, airway hyperreactivity, and atopy; however, our understanding of these relationships from early in life remains unclear. Respiratory tract illnesses and atopic sensitization early in life might produce an interaction between innate and acquired immune responses, leading to airway inflammation and heightened airway reactivity. Objective: We hypothesized that premorbid airway reactivity and immunologic characteristics of infants without prior episodes of wheezing would be associated with subsequent wheezing during a 1-year follow-up. Methods: One hundred sixteen infants with chronic dermatitis were enrolled before episodes of wheezing. Airway reactivity, allergen-specific IgE levels, cytokine production by stimulated PBMCs, and percentages of dendritic cells were measured on entry, and airway reactivity was reassessed at the 1-year follow-up. Linear regression models were used to evaluate a predictor's effect on continuous outcomes. Results: Milk sensitization, egg sensitization, or both were associated with heightened airway reactivity before wheezing and after the onset of wheezing; however, these factors were not associated with an increased risk of wheezing. There was an interaction between initial airway reactivity and wheezing as a determinant of airway reactivity at follow-up. In addition, cytokine production by stimulated PBMCs was a risk factor for wheezing, whereas increased percentages of conventional dendritic cells were protective against wheezing. Conclusion: Our data in a selected cohort of infants support a model with multiple risk factors for subsequent wheezing that are independent of initial airway reactivity; however, the causative factors that produce wheezing very early in life might contribute to heightened airway reactivity.

KW - airway reactivity

KW - atopy

KW - cytokines

KW - dendritic cells

KW - dermatitis

KW - food allergy

KW - Infants

KW - wheezing

UR - http://www.scopus.com/inward/record.url?scp=77956373600&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956373600&partnerID=8YFLogxK

U2 - 10.1016/j.jaci.2010.06.028

DO - 10.1016/j.jaci.2010.06.028

M3 - Article

C2 - 20816184

AN - SCOPUS:77956373600

VL - 126

SP - 483-488.e1

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

SN - 0091-6749

IS - 3

ER -