Evaluation of antithyroglobulin antibodies after routine vaccination in pet and research dogs

J. Catharine Scott-Moncrieff, Juan Azcona-Olivera, Nita W. Glickman, Lawrence T. Glickman, Harm HogenEsch

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Objective -To determine whether routine vaccination induces antibodies against bovine thyroglobulin and autoantibodies against canine thyroglobulin in dogs. Design - Prospective study. Animals - 20 healthy research Beagles and 16 healthy pet dogs. Procedure - For the research Beagles, 5 dogs were vaccinated with a multivalent vaccine and a rabies vaccine, 5 dogs received only the multivalent vaccine, 5 dogs received only the rabies vaccine, and 5 dogs were unvaccinated controls. The multivalent vaccine was administered at 8, 10, 12, 16, 20, 26, and 52 weeks of age and every 6 months thereafter. The rabies vaccine was administered at 16 and 52 weeks of age and then once per year. Blood was collected from all dogs at 8, 16, and 26 weeks of age and then 4 times yearly. Assays for antibodies directed against bovine and canine thyroglobulin were performed prior to and 2 weeks after each yearly vaccination. For the pet dogs, blood was collected prior to and 2 weeks after 1 vaccination. Results - In the research Beagles, there was a significant increase in anti-bovine thyroglobulin antibodies in all vaccinated dogs, compared with control dogs. There was a significant increase in anti-canine thyroglobulin antibodies in the 2 groups of dogs that received the rabies vaccine but not in the group that received the multivalent vaccine alone. In the pet dogs, there was a significant increase in anti-canine thyroglobulin antibodies after vaccination but no significant change in anti-bovine thyroglobulin antibodies. Conclusions and Clinical Relevance - Recent vaccination may result in increased anti-canine thyroglobulin antibodies. Whether these antibodies have a deleterious effect on canine thyroid function is unknown.

Original languageEnglish (US)
Pages (from-to)515-521
Number of pages7
JournalJournal of the American Veterinary Medical Association
Volume221
Issue number4
StatePublished - Aug 15 2002
Externally publishedYes

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Pets
pets
Vaccination
vaccination
Dogs
antibodies
thyroglobulin
dogs
Research
Rabies Vaccines
Canidae
vaccines
Thyroglobulin
Vaccines
rabies
Beagle
anti-thyroglobulin
Antibodies
cattle
Autoantibodies

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Evaluation of antithyroglobulin antibodies after routine vaccination in pet and research dogs. / Scott-Moncrieff, J. Catharine; Azcona-Olivera, Juan; Glickman, Nita W.; Glickman, Lawrence T.; HogenEsch, Harm.

In: Journal of the American Veterinary Medical Association, Vol. 221, No. 4, 15.08.2002, p. 515-521.

Research output: Contribution to journalArticle

Scott-Moncrieff, JC, Azcona-Olivera, J, Glickman, NW, Glickman, LT & HogenEsch, H 2002, 'Evaluation of antithyroglobulin antibodies after routine vaccination in pet and research dogs', Journal of the American Veterinary Medical Association, vol. 221, no. 4, pp. 515-521.
Scott-Moncrieff, J. Catharine ; Azcona-Olivera, Juan ; Glickman, Nita W. ; Glickman, Lawrence T. ; HogenEsch, Harm. / Evaluation of antithyroglobulin antibodies after routine vaccination in pet and research dogs. In: Journal of the American Veterinary Medical Association. 2002 ; Vol. 221, No. 4. pp. 515-521.
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