Evaluation of Cerebrospinal Fluid Pressure by a Formula and Its Role in the Pathogenesis of Glaucoma

Laura Landi, Federica Casciaro, Serena Telani, Carlo E. Traverso, Alon Harris, Alice C. Verticchio Vercellin, Lauren Saint, Michele Iester

Research output: Contribution to journalArticle

Abstract

Purpose. To investigate potential associations between intraocular pressure (IOP) and cerebrospinal fluid pressure (CSFP) in patients with primary open-angle glaucoma (POAG) and healthy subjects. Methods. Forty-three subjects were recruited. Weight and height were measured to calculate body mass index (BMI), along with blood pressure, heart rate, visual acuity, and IOP. Biometrics exam, corneal pachymetry, peripapillary retinal nerve fiber layer (RNFL) thickness, and macular thickness were assessed. The visual field exam was performed on all patients, and both pattern standard deviation (PSD) and mean deviation (MD) were considered. CSFP was estimated indirectly by using the mathematical formula CSFP = 0.44 × BMI + 0.16 × diastolic pressure - 0.18 × age - 1.91, based on the previous scientific studies. The TLCPD was calculated as follows: IOP-CSFP. Results. A significant (p<0.05) difference was found between the two groups for several parameters. Specifically, the CSFP was lower in patients with POAG than in healthy subjects (8.14 ± 4.52 and 7.43 ± 2.06, p<0.001, respectively). Anamnestic TLCPD was found to be significantly (p<0.001) higher in patients with POAG compared to healthy subjects. A significant (p<0.05) correlation was found between anamnestic TLCPD and MD (r = -0.31), inferior RNFL thickness (r = -0.29), superior RNFL thickness (r = -0.27), IOP (r = 0.22), and CSFP (r = -0.46). Conclusion. The CSFP was lower in glaucomatous patients compared to healthy subjects, whereas the TLCPD was higher in glaucomatous patients compared to healthy subjects, even though this difference was not statistically significant. A higher TLCPD may damage the RNFL, resulting in functional visual field impairment.

Original languageEnglish (US)
Article number1840481
JournalJournal of Ophthalmology
Volume2019
DOIs
StatePublished - Jan 1 2019
Externally publishedYes

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Cerebrospinal Fluid Pressure
Glaucoma
Healthy Volunteers
Intraocular Pressure
Nerve Fibers
Body Mass Index
Corneal Pachymetry
Blood Pressure
Visual Field Tests
Aqueous Humor
Vision Disorders
Visual Fields
Visual Acuity
Heart Rate
Weights and Measures

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Landi, L., Casciaro, F., Telani, S., Traverso, C. E., Harris, A., Verticchio Vercellin, A. C., ... Iester, M. (2019). Evaluation of Cerebrospinal Fluid Pressure by a Formula and Its Role in the Pathogenesis of Glaucoma. Journal of Ophthalmology, 2019, [1840481]. https://doi.org/10.1155/2019/1840481

Evaluation of Cerebrospinal Fluid Pressure by a Formula and Its Role in the Pathogenesis of Glaucoma. / Landi, Laura; Casciaro, Federica; Telani, Serena; Traverso, Carlo E.; Harris, Alon; Verticchio Vercellin, Alice C.; Saint, Lauren; Iester, Michele.

In: Journal of Ophthalmology, Vol. 2019, 1840481, 01.01.2019.

Research output: Contribution to journalArticle

Landi, L, Casciaro, F, Telani, S, Traverso, CE, Harris, A, Verticchio Vercellin, AC, Saint, L & Iester, M 2019, 'Evaluation of Cerebrospinal Fluid Pressure by a Formula and Its Role in the Pathogenesis of Glaucoma', Journal of Ophthalmology, vol. 2019, 1840481. https://doi.org/10.1155/2019/1840481
Landi, Laura ; Casciaro, Federica ; Telani, Serena ; Traverso, Carlo E. ; Harris, Alon ; Verticchio Vercellin, Alice C. ; Saint, Lauren ; Iester, Michele. / Evaluation of Cerebrospinal Fluid Pressure by a Formula and Its Role in the Pathogenesis of Glaucoma. In: Journal of Ophthalmology. 2019 ; Vol. 2019.
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abstract = "Purpose. To investigate potential associations between intraocular pressure (IOP) and cerebrospinal fluid pressure (CSFP) in patients with primary open-angle glaucoma (POAG) and healthy subjects. Methods. Forty-three subjects were recruited. Weight and height were measured to calculate body mass index (BMI), along with blood pressure, heart rate, visual acuity, and IOP. Biometrics exam, corneal pachymetry, peripapillary retinal nerve fiber layer (RNFL) thickness, and macular thickness were assessed. The visual field exam was performed on all patients, and both pattern standard deviation (PSD) and mean deviation (MD) were considered. CSFP was estimated indirectly by using the mathematical formula CSFP = 0.44 × BMI + 0.16 × diastolic pressure - 0.18 × age - 1.91, based on the previous scientific studies. The TLCPD was calculated as follows: IOP-CSFP. Results. A significant (p<0.05) difference was found between the two groups for several parameters. Specifically, the CSFP was lower in patients with POAG than in healthy subjects (8.14 ± 4.52 and 7.43 ± 2.06, p<0.001, respectively). Anamnestic TLCPD was found to be significantly (p<0.001) higher in patients with POAG compared to healthy subjects. A significant (p<0.05) correlation was found between anamnestic TLCPD and MD (r = -0.31), inferior RNFL thickness (r = -0.29), superior RNFL thickness (r = -0.27), IOP (r = 0.22), and CSFP (r = -0.46). Conclusion. The CSFP was lower in glaucomatous patients compared to healthy subjects, whereas the TLCPD was higher in glaucomatous patients compared to healthy subjects, even though this difference was not statistically significant. A higher TLCPD may damage the RNFL, resulting in functional visual field impairment.",
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AU - Casciaro, Federica

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AU - Traverso, Carlo E.

AU - Harris, Alon

AU - Verticchio Vercellin, Alice C.

AU - Saint, Lauren

AU - Iester, Michele

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N2 - Purpose. To investigate potential associations between intraocular pressure (IOP) and cerebrospinal fluid pressure (CSFP) in patients with primary open-angle glaucoma (POAG) and healthy subjects. Methods. Forty-three subjects were recruited. Weight and height were measured to calculate body mass index (BMI), along with blood pressure, heart rate, visual acuity, and IOP. Biometrics exam, corneal pachymetry, peripapillary retinal nerve fiber layer (RNFL) thickness, and macular thickness were assessed. The visual field exam was performed on all patients, and both pattern standard deviation (PSD) and mean deviation (MD) were considered. CSFP was estimated indirectly by using the mathematical formula CSFP = 0.44 × BMI + 0.16 × diastolic pressure - 0.18 × age - 1.91, based on the previous scientific studies. The TLCPD was calculated as follows: IOP-CSFP. Results. A significant (p<0.05) difference was found between the two groups for several parameters. Specifically, the CSFP was lower in patients with POAG than in healthy subjects (8.14 ± 4.52 and 7.43 ± 2.06, p<0.001, respectively). Anamnestic TLCPD was found to be significantly (p<0.001) higher in patients with POAG compared to healthy subjects. A significant (p<0.05) correlation was found between anamnestic TLCPD and MD (r = -0.31), inferior RNFL thickness (r = -0.29), superior RNFL thickness (r = -0.27), IOP (r = 0.22), and CSFP (r = -0.46). Conclusion. The CSFP was lower in glaucomatous patients compared to healthy subjects, whereas the TLCPD was higher in glaucomatous patients compared to healthy subjects, even though this difference was not statistically significant. A higher TLCPD may damage the RNFL, resulting in functional visual field impairment.

AB - Purpose. To investigate potential associations between intraocular pressure (IOP) and cerebrospinal fluid pressure (CSFP) in patients with primary open-angle glaucoma (POAG) and healthy subjects. Methods. Forty-three subjects were recruited. Weight and height were measured to calculate body mass index (BMI), along with blood pressure, heart rate, visual acuity, and IOP. Biometrics exam, corneal pachymetry, peripapillary retinal nerve fiber layer (RNFL) thickness, and macular thickness were assessed. The visual field exam was performed on all patients, and both pattern standard deviation (PSD) and mean deviation (MD) were considered. CSFP was estimated indirectly by using the mathematical formula CSFP = 0.44 × BMI + 0.16 × diastolic pressure - 0.18 × age - 1.91, based on the previous scientific studies. The TLCPD was calculated as follows: IOP-CSFP. Results. A significant (p<0.05) difference was found between the two groups for several parameters. Specifically, the CSFP was lower in patients with POAG than in healthy subjects (8.14 ± 4.52 and 7.43 ± 2.06, p<0.001, respectively). Anamnestic TLCPD was found to be significantly (p<0.001) higher in patients with POAG compared to healthy subjects. A significant (p<0.05) correlation was found between anamnestic TLCPD and MD (r = -0.31), inferior RNFL thickness (r = -0.29), superior RNFL thickness (r = -0.27), IOP (r = 0.22), and CSFP (r = -0.46). Conclusion. The CSFP was lower in glaucomatous patients compared to healthy subjects, whereas the TLCPD was higher in glaucomatous patients compared to healthy subjects, even though this difference was not statistically significant. A higher TLCPD may damage the RNFL, resulting in functional visual field impairment.

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