Evaluation of diagnostic tests without gold standards

Siu L. Hui, Xiao H. Zhou

Research output: Contribution to journalReview articlepeer-review

188 Scopus citations


This paper reviews statistical methods developed to estimate the sensitivity and specificity of screening or diagnostic tests when the fallible test are not evaluated against a gold standard. It gives a brief summary of the earlier historical developments and focuses on the more recent methods. It covers Bayesian approaches and longitudinal studies with repeated testing. In particular, it reviews the procedures that do not require the assumption of independence between tests conditional on the true disease status.

Original languageEnglish (US)
Pages (from-to)354-370
Number of pages17
JournalStatistical Methods in Medical Research
Issue number4
StatePublished - 1998

ASJC Scopus subject areas

  • Epidemiology
  • Statistics and Probability
  • Health Information Management

Fingerprint Dive into the research topics of 'Evaluation of diagnostic tests without gold standards'. Together they form a unique fingerprint.

Cite this