Evaluation of Kidney Function in Patients with Acute Renal Failure Using High-Performance Liquid Chromatography

A Case Report

Rajiv Agarwal, Nina Vasavada, Shawn D. Chase

Research output: Contribution to journalArticle

Abstract

Accurate measurement of glomerular function rate (GFR) in the setting of acute renal failure is difficult to achieve with current clinical methods, such as measuring plasma creatinine concentration and 24-hour urine creatinine clearance. High-performance liquid chromatography was used to measure GFR directly in a critically ill patient with acute renal failure. This approach involved evaluating the elimination kinetics of nonionic contrast material administered intravenously for radiologic imaging. It required no additional patient exposure to radiographic contrast media and enabled caregivers to determine kidney function accurately in the presence of worsening clinical status and delayed changes in plasma creatinine. This and other methods for more accurate measurement of GFR in patients with acute renal failure may provide the foundation for clinical studies that assess the severity and management of acute renal failure.

Original languageEnglish
Pages (from-to)145-149
Number of pages5
JournalPharmacotherapy
Volume24
Issue number1
DOIs
StatePublished - Jan 2004

Fingerprint

Acute Kidney Injury
High Pressure Liquid Chromatography
Kidney
Creatinine
Contrast Media
Critical Illness
Caregivers
Urine

Keywords

  • Acute renal failure
  • Contrast media
  • High-performance liquid chromatography
  • Iopamidol

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Evaluation of Kidney Function in Patients with Acute Renal Failure Using High-Performance Liquid Chromatography : A Case Report. / Agarwal, Rajiv; Vasavada, Nina; Chase, Shawn D.

In: Pharmacotherapy, Vol. 24, No. 1, 01.2004, p. 145-149.

Research output: Contribution to journalArticle

@article{3d8149e866e74e499e4c39ed8006521e,
title = "Evaluation of Kidney Function in Patients with Acute Renal Failure Using High-Performance Liquid Chromatography: A Case Report",
abstract = "Accurate measurement of glomerular function rate (GFR) in the setting of acute renal failure is difficult to achieve with current clinical methods, such as measuring plasma creatinine concentration and 24-hour urine creatinine clearance. High-performance liquid chromatography was used to measure GFR directly in a critically ill patient with acute renal failure. This approach involved evaluating the elimination kinetics of nonionic contrast material administered intravenously for radiologic imaging. It required no additional patient exposure to radiographic contrast media and enabled caregivers to determine kidney function accurately in the presence of worsening clinical status and delayed changes in plasma creatinine. This and other methods for more accurate measurement of GFR in patients with acute renal failure may provide the foundation for clinical studies that assess the severity and management of acute renal failure.",
keywords = "Acute renal failure, Contrast media, High-performance liquid chromatography, Iopamidol",
author = "Rajiv Agarwal and Nina Vasavada and Chase, {Shawn D.}",
year = "2004",
month = "1",
doi = "10.1592/phco.24.1.145.34806",
language = "English",
volume = "24",
pages = "145--149",
journal = "Pharmacotherapy",
issn = "0277-0008",
publisher = "Pharmacotherapy Publications Inc.",
number = "1",

}

TY - JOUR

T1 - Evaluation of Kidney Function in Patients with Acute Renal Failure Using High-Performance Liquid Chromatography

T2 - A Case Report

AU - Agarwal, Rajiv

AU - Vasavada, Nina

AU - Chase, Shawn D.

PY - 2004/1

Y1 - 2004/1

N2 - Accurate measurement of glomerular function rate (GFR) in the setting of acute renal failure is difficult to achieve with current clinical methods, such as measuring plasma creatinine concentration and 24-hour urine creatinine clearance. High-performance liquid chromatography was used to measure GFR directly in a critically ill patient with acute renal failure. This approach involved evaluating the elimination kinetics of nonionic contrast material administered intravenously for radiologic imaging. It required no additional patient exposure to radiographic contrast media and enabled caregivers to determine kidney function accurately in the presence of worsening clinical status and delayed changes in plasma creatinine. This and other methods for more accurate measurement of GFR in patients with acute renal failure may provide the foundation for clinical studies that assess the severity and management of acute renal failure.

AB - Accurate measurement of glomerular function rate (GFR) in the setting of acute renal failure is difficult to achieve with current clinical methods, such as measuring plasma creatinine concentration and 24-hour urine creatinine clearance. High-performance liquid chromatography was used to measure GFR directly in a critically ill patient with acute renal failure. This approach involved evaluating the elimination kinetics of nonionic contrast material administered intravenously for radiologic imaging. It required no additional patient exposure to radiographic contrast media and enabled caregivers to determine kidney function accurately in the presence of worsening clinical status and delayed changes in plasma creatinine. This and other methods for more accurate measurement of GFR in patients with acute renal failure may provide the foundation for clinical studies that assess the severity and management of acute renal failure.

KW - Acute renal failure

KW - Contrast media

KW - High-performance liquid chromatography

KW - Iopamidol

UR - http://www.scopus.com/inward/record.url?scp=0347357816&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0347357816&partnerID=8YFLogxK

U2 - 10.1592/phco.24.1.145.34806

DO - 10.1592/phco.24.1.145.34806

M3 - Article

VL - 24

SP - 145

EP - 149

JO - Pharmacotherapy

JF - Pharmacotherapy

SN - 0277-0008

IS - 1

ER -